Effect of Dietary L-arabinose on the Intestinal Microbiota and Metabolism of Dietary Daidzein in Adult Mice

Tamura, Motoi; Hori, Shingo

doi:10.12938/bmfh.31.59

Cited by 15 publications

(14 citation statements)

References 33 publications

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“…However, several studies focussed on how other substrates modulate the IM, and, in turn, affect daidzein metabolism. Three studies in mice investigated how other dietary components such as xylitol, arabinose, or rice bran oil may change the gut microbial composition which, in turn, may also affect daidzein metabolism [ 95 – 97 ]. In all studies, two groups of mice were fed either 0.05% daidzein in the diet alone or together with 5% xylitol, 10% rice bran oil (in this case the daidzein group also received 10% lard as control) or 2.5% arabinose in their diets.…”

Section: Resultsmentioning

confidence: 99%

“…l -Arabinose-fed mice had lower urinary amounts of daidzein and the ratio of equol/daidzein was significantly compared to the control group. The abundance of Prevotella and Lactobacillales were significantly lower in the arabinose group [ 95 ].…”

Section: Resultsmentioning

confidence: 99%

“…This variation resulted in different host exposures to bioactive compounds and could explain variation in the effectiveness of the interventions. Indeed, research by several authors [ 84 , 89 , 92 , 95 – 97 ] demonstrated the potential utility of using pre- and probiotics, xylitol, arabinose or rice bran oil administration to manipulate IM interactions to alter polyphenol bioavailability/metabolism and minimize this variation. In addition, a recent study using radiolabelled (−)-epicatechin demonstrated considerable variation in the microbial processing of this flavanol between humans and rats and to a lesser extent between humans and mice.…”

Section: Discussionmentioning

confidence: 99%

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Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients

Shortt

Hasselwander

Meynier³

et al. 2017

Eur J Nutr

155

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PurposeThere is considerable interest in the effects of the intestinal microbiota (IM) composition, its activities in relation with the metabolism of dietary substrates and the impact these effects may have in the development and prevention of certain non-communicable diseases. It is acknowledged that a complex interdependence exists between the IM and the mammalian host and that the IM possesses a far greater diversity of genes and repertoire of metabolic and enzymatic capabilities than their hosts. However, full knowledge of the metabolic activities and interactions of the IM and the functional redundancy that may exist are lacking. Thus, the current review aims to assess recent literature relating to the role played by the IM in the absorption and metabolism of key nutrients and non-nutrients.MethodsA systematic review (PROSPERO registration: CRD42015019087) was carried out focussing on energy and the following candidate dietary substrates: protein, carbohydrate, fat, fibre, resistant starch (RS), and polyphenols to further understand the effect of the IM on the dietary substrates and the resulting by-products and host impacts. Particular attention was paid to the characterisation of the IM which are predominantly implicated in each case, changes in metabolites, and indirect markers and any potential impacts on the host.ResultsStudies show that the IM plays a key role in the metabolism of the substrates studied. However, with the exception of studies focusing on fibre and polyphenols, there have been relatively few recent human studies specifically evaluating microbial metabolism. In addition, comparison of the effects of the IM across studies was difficult due to lack of specific analysis/description of the bacteria involved. Considerable animal-derived data exist, but experience suggests that care must be taken when extrapolating these results to humans. Nevertheless, it appears that the IM plays a role in energy homeostasis and that protein microbial breakdown and fermentation produced ammonia, amines, phenols and branch chain fatty acids, and a greater diversity in the microbes present. Few recent studies appear to have evaluated the effect of the IM composition and metabolism per se in relation with digestible dietary carbohydrate or fat in humans. Intakes of RS and prebiotics altered levels of specific taxa that selectively metabolised specific prebiotic/carbohydrate-type substances and levels of bifidobacteria and lactobacilli were observed to increase. In controlled human studies, consistent data exist that show a correlation between the intake of fibre and an increase in bifidobacteria and short-chain fatty acids, in particular butyrate, which leads to lower intestinal pH. Dietary polyphenols rely on modification either by host digestive enzymes or those derived from the IM for absorption to occur. In the polyphenol-related studies, a large amount of inter-individual variation was observed in the microbial metabolism and absorption of certain polyphenols.ConclusionsThe systematic review demonstrates t...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients

Shortt

Hasselwander

Meynier³

et al. 2017

Eur J Nutr

155

View full text Add to dashboard Cite

show abstract

“…The current studies also only establish correlation not causation. One study in mice showed that dietary supplementation with daidzein and arabinose resulted in lower relative amounts of Prevotella but increased the ratio of equol/daidzein compared to supplementation of daidzein alone, suggesting that providing both daidzein and arabinose increases gut bacteria capable of metabolizing daidzein to equol 54 . Comparably, no other studies have shown that the other bacteria listed above can serve as equol producers.…”

Section: Discussionmentioning

confidence: 99%

Soy-Induced Fecal Metabolome Changes in Ovariectomized and Intact Female Rats: Relationship with Cardiometabolic Health

Vieira‐Potter

Cross

Swanson

et al. 2018

Sci Rep

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Phytoestrogens are plant-derived compounds found in a variety of foods, most notably, soy. These compounds have been shown to improve immuno-metabolic health, yet mechanisms remain uncertain. We demonstrated previously that dietary phytoestrogen-rich soy (SOY) rescued metabolic dysfunction/inflammation following ovariectomy (OVX) in female rats; we also noted remarkable shifts in gut microbiota in SOY vs control diet-fed rats. Importantly, specific bacteria that significantly increased in those fed the SOY correlated positively with several favorable host metabolic parameters. One mechanism by which gut microbes might lead to such host effects is through production of bacterial metabolites. To test this possibility, we utilized non-targeted gas chromatography–mass spectrometry (GCMS) to assess the fecal metabolome in those previously studied animals. Partial least square discriminant analysis (PLSDA) revealed clear separation of fecal metabolomes based on diet and ovarian state. In particular, SOY-fed animals had greater fecal concentrations of the beneficial bacterial metabolite, S-equol, which was positively associated with several of the bacteria upregulated in the SOY group. S-equol was inversely correlated with important indicators of metabolic dysfunction and inflammation, suggesting that this metabolite might be a key mediator between SOY and gut microbiome-positive host health outcomes.

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“…Of the 23 biomarkers identified in the CSB, arabinose and α- and γ-tocopherol ( Table 4 ) have been previously reported in soybean literature ( 43 ). Arabinose may be converted into short-chain FAs by bacteria to support healthy enterocyte metabolism, bolster gut mucosal immunity, and beneficially modulate the microbiome ( 80 – 82 ). α- and γ-Tocopherol possess broad-spectrum antioxidant and immunomodulatory activities ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

The Nutrient and Metabolite Profile of 3 Complementary Legume Foods with Potential to Improve Gut Health in Rural Malawian Children

Borresen

Zhang

Trehan

et al. 2017

Current Developments in Nutrition

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Background: Environmental enteric dysfunction (EED), frequently seen in rural Malawian children, causes chronic inflammation and increases the risk of stunting. Legumes may be beneficial for improving nutrition and reducing the risk of developing EED in weaning children. Objective: The objectives of this study were to determine the nutritional value, verify the food safety, and identify metabolite profiles of 3 legume-based complementary foods: common bean (CB), cowpea (CP), and traditional corn-soy blend (CSB). Methods: Foods were prepared by using local ingredients and analyzed for nutrient composition with the use of Association of Official Analytical Chemists (AOAC) standards (950.46, 991.43, 992.15, 996.06, and 991.36) for macro- and micronutrient proximate analysis. Food safety analysis was conducted in accordance with the Environmental Protection Agency (7471B) and AOAC (2008.02) standards. The metabolite composition of foods was determined with nontargeted ultra-performance LC–tandem mass spectrometry metabolomics. Results: All foods provided similar energy; CB and CP foods contained higher protein and dietary fiber contents than did the CSB food. Iron and zinc were highest in the CSB and CP foods, whereas CB and CP foods contained higher amounts of magnesium, phosphorus, and potassium. A total of 652 distinct metabolites were identified across the 3 foods, and 23, 14, and 36 metabolites were specific to the CSB, CB, and CP foods, respectively. Among the potential dietary biomarkers of intake to distinguish legume foods were pipecolic acid and oleanolic acid for CB; arabinose and serotonin for CSB; and quercetin and α- and γ-tocopherol acid for CP. No heavy metals were detected, and aflatoxin was measured only in the CSB (5.2 parts per billion). Conclusions: Legumes in the diet provide a rich source of protein, dietary fiber, essential micronutrients, and phytochemicals that may reduce EED. These food metabolite analyses identified potential dietary biomarkers of legume intake for stool, urine, and blood detection that can be used in future studies to assess the relation between the distinct legumes consumed and health outcomes. This trial was registered at clinicaltrials.gov as NCT02472262 and NCT02472301.

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Effect of Dietary L-arabinose on the Intestinal Microbiota and Metabolism of Dietary Daidzein in Adult Mice

Cited by 15 publications

References 33 publications

Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients

Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients

Soy-Induced Fecal Metabolome Changes in Ovariectomized and Intact Female Rats: Relationship with Cardiometabolic Health

The Nutrient and Metabolite Profile of 3 Complementary Legume Foods with Potential to Improve Gut Health in Rural Malawian Children

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