Effect of Dietary Organic Acids and Humic Substance Supplementation on Performance, Immune Response and Gut Morphology of Broiler Chickens

Aristimunha, P. C.; Mallheiros, R.D.; Ferket, P. R.; Cardinal, Kátia Maria; Filho, Alexandre Lemos de Barros Moreira; Santos, Elaine Talita; Cavalcante, Danilo Teixeira; Ribeiro, Aml

doi:10.3382/japr/pfz031

Cited by 18 publications

(6 citation statements)

References 34 publications

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“…However, other studies showed that egg shell quality was improved in Isa Brown layers fed diets supplemented with humic acid (Ozturk et al, 2009). Several reports have indicated no favourable effects of humates in broilers raised in conditions without pathogens (Aristimunha et al, 2019;Leeson et al, 2005), but there is improvement with supplementation of humic acid during immune stress (Edmonds et al, 2014). However, many gut enhancing effects of feed ingredients, including antibiotics, are not seen under sterile rearing conditions (Cowieson and Kluenter, 2019).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with sodium humate improves egg quality and immune function of laying hens

Zhang

Pirzado

Liu

et al. 2020

JAAN

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The aim of this study was to evaluate the influence of the dietary addition of sodium humate (HAS) on performance and immune response of laying hens during peak lay, over an eight-week period. Laying hens, aged 24 weeks old, were randomly allotted to four dietary treatments: a basal control diet or the basal diet supplemented with 0.1, 0.3 or 0.5% HAS. Each treatment had six replicates with 15 layers per replicate. Egg production, egg quality, serum antioxidant parameters and immunity indexes were measured. HAS had no significant effect on egg production or egg and shell quality, but all supplemental levels significantly improved Haugh unit values and egg yolk colour. Supplementation with all levels of HAS significantly increased serum immunoglobuline (Ig) level compared to the hens fed the control diet. Feeding either 0.1 or 0.5% HAS significantly increased serum IgM levels. The results indicated that dietary supplementation with HAS can enhance egg albumin quality and improve immunity in laying hens.

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Section: Discussionmentioning

confidence: 99%

Dietary supplementation with sodium humate improves egg quality and immune function of laying hens

Zhang

Pirzado

Liu

et al. 2020

JAAN

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“…The findings of this study also solidify the potential of HA as a valuable tool in mitigating AFB 1 ’s detrimental effects on turkey poults. By improving gut integrity, promoting beneficial gut bacteria, improving intestinal morphometry, and enhancing cellular immunity, HA can potentially reduce performance losses, improve feed conversion ratio, and increase body weight gain, according to a previously published study [ 18 ]. Enhanced gut health can also protect poults from AFB 1 -induced intestinal damage, inflammation, and secondary bacterial or viral infections.…”

Section: Discussionmentioning

confidence: 99%

“…The potential of HA to increase Firmicutes in poults, both with and without AFB 1 exposure, is an intriguing area of research with promising implications for poultry health and mycotoxin control. Some of the potential mechanisms for increased Firmicutes with HA may include the following: (A) A prebiotic effect—HA, particularly fulvic acid, contain complex organic molecules with prebiotic properties [ 18 ]. These molecules can stimulate the growth of beneficial bacteria, including Firmicutes, by providing them with readily available energy sources and enhancing their metabolic activity [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Impact of Humic Acids on Intestinal Microbiota, Gut Integrity, Ileum Morphometry, and Cellular Immunity of Turkey Poults Fed an Aflatoxin B1-Contaminated Diet

Maguey-González,

Liu,

Zhang

et al. 2024

Toxins

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A recent study published data on the growth performance, relative weights of the organs of the gastrointestinal tract, liver histology, serum biochemistry, and hematological parameters for turkey poults fed an experimental diet contaminated with aflatoxin B1 (AFB1) and humic acids (HA) extracted from vermicompost. The negative effects of AFB1 (250 ng AFB1/g of feed) were significantly reduced by HA supplementation (0.25% w/w), suggesting that HA might be utilized to ameliorate the negative impact of AFB1 from contaminated diets. The present study shows the results of the remaining variables, as an extension of a previously published work which aimed to evaluate the impact of HA on the intestinal microbiota, gut integrity, ileum morphometry, and cellular immunity of turkey poults fed an AFB1-contaminated diet. For this objective, five equal groups of 1-day-old female Nicholas-700 turkey poults were randomly assigned to the following treatments: negative control (basal diet), positive control (basal diet + 250 ng AFB1/g), HA (basal diet + 0.25% HA), HA + AFB1 (basal diet + 0.25% HA + 250 ng AFB1/g), and Zeolite (basal diet + 0.25% zeolite + 250 ng AFB1/g). In the experiment, seven replicates of ten poults each were used per treatment (n = 70). In general, HA supplementation with or without the presence of AFB1 showed a significant increase (p < 0.05) in the number of beneficial butyric acid producers, ileum villi height, and ileum total area, and a significant reduction in serum levels of fluorescein isothiocyanate–dextran (FITC-d), a marker of intestinal integrity. In contrast, poults fed with AFB1 showed a significant increase in Proteobacteria and lower numbers of beneficial bacteria, clearly suggesting gut dysbacteriosis. Moreover, poults supplemented with AFB1 displayed the lowest morphometric parameters and the highest intestinal permeability. Furthermore, poults in the negative and positive control treatments had the lowest cutaneous basophil hypersensitivity response. These findings suggest that HA supplementation enhanced intestinal integrity (shape and permeability), cellular immune response, and healthier gut microbiota composition, even in the presence of dietary exposure to AFB1. These results complement those of the previously published study, suggesting that HA may be a viable dietary intervention to improve gut health and immunity in turkey poults during aflatoxicosis.

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“…The results of this experiment are consistent with the results of similar experiments. According to a study by Aristimunha et al (2020), the addition of 0.1% acid to the diet of broilers increased the antibody titer against Newcastle disease and influenza. They have suggested that the increase may be due to the stimulation of the immune system.…”

Section: O N L I N E F I R S T a R T I C L Ementioning

confidence: 99%

Effect of Some Abiotic Factors on Migration of Sunn Pest (Eurygaster integriceps Put.) (Hemiptera: Scutelleridae) from Aestivation Sites to Overwinteing Sites

İslamoğlu¹

2022

PJZ

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Effect of Dietary Organic Acids and Humic Substance Supplementation on Performance, Immune Response and Gut Morphology of Broiler Chickens

Cited by 18 publications

References 34 publications

Dietary supplementation with sodium humate improves egg quality and immune function of laying hens

Dietary supplementation with sodium humate improves egg quality and immune function of laying hens

Assessment of the Impact of Humic Acids on Intestinal Microbiota, Gut Integrity, Ileum Morphometry, and Cellular Immunity of Turkey Poults Fed an Aflatoxin B1-Contaminated Diet

Effect of Some Abiotic Factors on Migration of Sunn Pest (Eurygaster integriceps Put.) (Hemiptera: Scutelleridae) from Aestivation Sites to Overwinteing Sites

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