Effect of Dietary Protein and Lipid on the Activity of Hepatic Mixed-Function Oxidase System in Young and Adult Rats

Antal, M.; Nagy, Katalin; Bedö, M.

doi:10.1159/000176590

Cited by 14 publications

(4 citation statements)

References 20 publications

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“…Corn oil, olive oil, and sunflower oil supplementation at levels ranging from 0.5 to 30% of total food intake are reported to increase hepatic CYP content and catalytic activity. 7, 11, 17, 18 However, in another study, sunflower oil decreased the total protein content 19. Yoo et al11 reported that rats given 20% corn oil supplement for 4 days had an increase in the 6β‐testosterone hydroxylation, but had no change in 7α‐ and 16α‐testosterone hydroxylation.…”

Section: Discussionmentioning

confidence: 98%

Effect of dietary oil intake on hepatic cytochrome P450 activity in the rat

Brunner

Bai

2000

J. Pharm. Sci.

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Section: Discussionmentioning

confidence: 98%

Effect of dietary oil intake on hepatic cytochrome P450 activity in the rat

Brunner

Bai

2000

J. Pharm. Sci.

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“…However, as shown in Table 3, the increase is at best modest and the minor variation is unlikely to be of any important physiological significance. Concerning the effect of protein quantity on the activity of liver microsomal MFO system, it has been shown so far that diets with lower levels of casein (5-12% by weight) decrease the activities of liver microsomal MFO system as measured by cytochrome P-450, O-deethylase, O-demethylase, N-demethylase and hydroxylase compared with a diet containing a normal level of casein (20% by weight) (2,4,8,9,11,(13)(14)(15). This discrepancy between these and our results appears to depend on protein quality, where casein has limiting amino acids and whole egg protein no limiting amino acids.…”

Section: Discussionmentioning

confidence: 99%

“…SAITO et al normal levels (2,4,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). By contrast, dietary protein excess is reported to increase (11) or decrease (13) the activity of liver microsomal MFO system.…”

mentioning

confidence: 99%

Liver Microsomal Mixed-Function Oxidases in Response to Dietary Whole Egg Protein Levels in Rats.

Saito

Oh-hashi

Yamaguchi

1992

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryRelation between the activity of liver microsomal mixed function oxidase system and dietary protein level was investigated in rats using purified whole egg protein, i.e. free from limiting amino acids . The animals were given either a diet containing 0, 5, 10, 20 or 40% of protein (experiment 1) or a diet containing 5, 10, 15 or 20% of protein (exper iment 2) for 16 days. In experiment 2, half of the rats of each group were intraperitoneally injected sodium phenobarbital (PB) to induce the mix ed-function oxidase system. The cytochrome P-450 content plateaued even at 5% level of dietary protein in experiment 1 and in the PB -untreated groups of experiment 2. However, it showed the highest value at 15% protein level in the PB-treated groups of experiment 2, indicating a shift of the response peak to a higher protein level due to an increase in protein requirement. Cytochrome P-450 reflected most specifically the dietary protein levels when the enzyme system was induced by PB . The 15% protein level, equivalent to 14.1 protein calories % , is a little higher than the optimal dietary level of whole egg protein ever obtained by usual nutritional indices.

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“…In a similar pattern, aniline hydroxylase was in a trend to increase by feeding CO. The MFO system in the liver plays a crucial role in the metabolism of endogenous steroids (TAKAHASHI and JENSEN,1984) and the maintenance and induction of MFO system are optimized by dietary fat in rats (ANTAL et al, 1982).…”

Section: Effects Of Dietary Fat Sourcesmentioning

confidence: 99%

Effects of Dietary Fat and Protein Sources on Performance, Lipid Content and Mixed Function Oxidase in Liver, and Fat Deposition and Adipocyte Cellularity in Abdomen in Broiler Chickens.

et al. 1994

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Abdominal fat deposition and the cellularity, and lipid content and mixed function oxidase (MFO) activity in livers were studied in broiler chickens fed isoenergetic and isonitrogenous diets which were different in the fat and protein sources. Feeding corn oil (CO) or chicken oil (CH) tended to decrease abdominal fat content compared with feeding yellow grease (YG) at 56 days of age, although no significant differences were observed in general performance.In female chickens, the decrease in the abdominal fat pad was associated with decrease in the adipocyte volume. At 21 days of age, lipid and triglyceride contents in the liver of chickens fed CO or CH were numerically lower than those in YG-fed chicks, and hepatic MFO activity was elevated by feeding CO.Feeding high fat diet (HF) increased liver triglyceride content at 21 days and tended to increase abdominal fat content at 56 days of age. Feeding fish meal (FM) as a major protein source increased the abdominal fat content in comparison with feeding soybean meal+fish meal (SFM), irrespective of dietary fat content, at 21 days of age. In chickens fed low fat diet (LF) for 21 days, FM decreased lipid and triglyceride contents in the liver and the decrease was associated with an activation of the hepatic MFO activity.

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Effect of Dietary Protein and Lipid on the Activity of Hepatic Mixed-Function Oxidase System in Young and Adult Rats

Cited by 14 publications

References 20 publications

Effect of dietary oil intake on hepatic cytochrome P450 activity in the rat

Effect of dietary oil intake on hepatic cytochrome P450 activity in the rat

Liver Microsomal Mixed-Function Oxidases in Response to Dietary Whole Egg Protein Levels in Rats.

Effects of Dietary Fat and Protein Sources on Performance, Lipid Content and Mixed Function Oxidase in Liver, and Fat Deposition and Adipocyte Cellularity in Abdomen in Broiler Chickens.

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