Mentally retarded obese in-patients were fed by low-energy diet (4.2-4.6 MJ) for 9 months. During this period, an average of 13 +/- 4.5 kg loss of body mass occurred in men and 16 +/- 2.7 kg in women. Anthropometric measurements were performed before starting the dietotherapy and in the ninth month. Changes of body fat could be followed well when calculated according to BMI. Less reliable results were obtained with skinfold thickness measurements, presumably due to body deformities. Results of clinical laboratory tests, which were carried out before starting the dietotherapy and in the fourth and seventh months, suggested that a low-energy-containing diet with balanced nutrient content and adequate protein intake did not impair protein metabolism, favourably affected serum triglyceride and cholesterol levels, but resulted in an unfavourable decrease in the HDL-cholesterol content.

Effects of marginal or normal casein diets with different sunflower oil contents were tested on the hepatic mixed-function oxidase system in young and adult male rats. The weight gain and the activity of aminopyrine demethylase, aniline hydroxylase and the content of cytochrome P-450 was decreased only in young rats fed 10% casein and 10% oil containing diets. Both in young and adult animals, independently of casein consumption, the activity of MFO with the exception of cytochrome P-450 in adult rats fed 20% casein was significantly higher when the level of dietary sunflower oil was shifted from 10 to 30%.

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Die Wirkung von Coffein bzw. von Barbiturat sowie die der simultanen Verabreichung dieser Medikamente auf den Stoffwechsel junger ausgewachsener Ratten wurde untersucht. Es wurden 4 Monate hindurch pro Tier und Tag 1, 7 mg Coffein oder 1, 7 mg Barbiturat bzw. 1,7 mg Coffein + 1,7 mg Barbiturat verabreicht.