Die Wirkung langfristig verabreichter Medikamente auf die Nährstoffverwertung. 3. Mitt. Die Wirkung von Coffein und Barbiturat auf den Stoffwechsel weißer Ratten

Krämer, M.; Tarjan, Robert E.; Bedö, M.; Dworschák, E.; Kováts, M. Telegdy

doi:10.1002/food.19690130702

Nahrung

1969

DOI: 10.1002/food.19690130702

|View full text |Cite

Die Wirkung langfristig verabreichter Medikamente auf die Nährstoffverwertung. 3. Mitt. Die Wirkung von Coffein und Barbiturat auf den Stoffwechsel weißer Ratten

M. Krämer¹,

Robert E. Tarjan²,

M. Bedö³

et al.

Abstract: Die Wirkung von Coffein bzw. von Barbiturat sowie die der simultanen Verabreichung dieser Medikamente auf den Stoffwechsel junger ausgewachsener Ratten wurde untersucht. Es wurden 4 Monate hindurch pro Tier und Tag 1, 7 mg Coffein oder 1, 7 mg Barbiturat bzw. 1,7 mg Coffein + 1,7 mg Barbiturat verabreicht.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1984

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Untersuchungen über die Wirkung von Coffein auf ausgewählte Stoffwechselparameter in vivo

Sachs

Förster

1984

Z Ernährungswiss

View full text Add to dashboard Cite

The metabolic actions of caffeine were investigated in the rat (90 mg/kg bw caffeine intravenously during 3 hours) and in human volunteers (35 mg/kg bw caffeine orally) in the fasting state. Additionally, the effects of caffeine were measured during simultaneous intravenous glucose infusion (0.25 mg/kg bw/h during 6 hours in humans and 1.8 mg/kg bw/h during 3 hours in the rat). In the fasting rat, intravenous caffeine caused an increase in the serum concentrations of glucose, urea, insulin, and free fatty acids, whereas a decrease in glucoplastic amino acids was found. As the liver glycogen concentration was not altered, the increase in blood glucose should be due to an increase in glyconeogenesis. During simultaneous application of carbohydrates and caffeine, the increases in the concentration of blood glucose and serum insulin were intensified, whereas the serum concentrations of lactate and urea as well as hepatic glycogen were not altered. In fasting male volunteers caffeine caused an increase in the concentrations of blood glucose, cortisol, insulin, free fatty acids, free glycerol and ketone bodies. During intravenous glucose infusion, caffeine intensified the decrease in serum phosphate induced by carbohydrates. Neither in volunteers nor in the experimental animal, an alteration in the concentrations of cholesterol or serum triglycerides or serum uric acid was effected by caffeine. It is concluded that high dosed caffeine causes peripheral insulin resistance in the human being as well as in the experimental animal. This peripheral insulin resistance is shown by the simultaneous large increases in concentrations of serum insulin, blood glucose and concentration of free fatty acids. In this situation insulin obviously is not able to inhibit lipolysis or gluconeogenesis nor to increase peripheral glucose utilisation. These metabolic effects of caffeine show some similarities to the metabolic situation in diabetes mellitus type 2 (Non Insulin Dependent Diabetes mellitus).

show abstract

Untersuchungen über die Wirkung von Coffein auf ausgewählte Stoffwechselparameter in vivo

Sachs

Förster

1984

Z Ernährungswiss

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Die Wirkung langfristig verabreichter Medikamente auf die Nährstoffverwertung. 3. Mitt. Die Wirkung von Coffein und Barbiturat auf den Stoffwechsel weißer Ratten

Cited by 1 publication

References 16 publications

Untersuchungen über die Wirkung von Coffein auf ausgewählte Stoffwechselparameter in vivo

Untersuchungen über die Wirkung von Coffein auf ausgewählte Stoffwechselparameter in vivo

Contact Info

Product

Resources

About