Effect of dietary supplementation of l-carnitine on serum lipid profile and antioxidant status in broiler chicken fed with animal fat-rich diet

Murali, P.V.; George, Samuel D.; Dominic, George

doi:10.5958/0974-4517.2020.00017.8

Cited by 8 publications

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“…The alpha-lipoic acid is a reliable antioxidant agent used in oxidative stress-related clinical conditions like (diabetes mellitus, neuropathy, neurodegenerative disease, and cardiovascular disorder, obesity vertigo, and others [10][11][12][13][14][15] Our study determines the pharmacokinetic parameters of the intraperitoneal dose alpha-lipoic acid at 80mg/kg bw in broiler chicks. Our findings are in agreement with studies carried out on rats and humans 16,17 When ALA is given orally or intravenously, it is metabolized in the body after absorption from the stomach and small intestine and spreads to the liver through the portal circulation and to the rest of the body through the systemic circulation 18 . ALA is soluble in water, hydrophilic and lipophilic 19 , so it can cross the blood-brain barrier and can exist both inside and outside the cell and inside mitochondria.…”

Section: Measuring the Pharmacokinetics Of Alpha-lipoic Acid In Chick...supporting

confidence: 92%

Estimation of pharmacokinetic parameters of alpha-lipoic acid in the chicks model

Abdulghani

Naser

2022

Baghdad J. Biochem. Appl. Biol. Sci.

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Background and objective: Alpha-lipoic acid is a drug used to treat diabetic neuropathy, and it has other uses as a dietary supplement. The target of the study was to investigate the concentration of therapeutic doses of Alpha-lipoic acid in the blood plasma of broiler chicks to define the pharmacokinetic parameters. Methods: A randomized controlled study was performed on thirty-five healthy broiler chicks of seven days old, chicks were injected into the peritoneum with a single dose of analgesic ED50 80mg /kg b.wt, following injection of the drug, blood samples were collected at 0.25, 0.5, 1, 2, 4, 24 h (five chicks per time) from the jugular vein. Then the blood plasma was obtained, the concentrations of Alpha-lipoic acid in blood plasma samples were determined utilizing UV Spectrometric Method, the pharmacokinetic parameters were determined by the PKSolver program. Time versus concentration curve for Alpha-lipoic acid was obtained from the program. The pharmacokinetic parameters were determined with non-compartmental models. Results: The concentration of Alpha-lipoic acid in the blood plasma of chicks injected with Alpha lipoic at a dose (80 mg/kg) were 134.6±7.17, 178.5±4.10 ,192.4±7.83 ,158.5±11.05 ,147.1±10.16, 122.8±7.09 µg/ml at times 0.25, 0.5, 1, 2, 4, and 24 hours respectively. The maximum plasma concentration was 192.4µg/ml during a period of 1 hour of injection. The terminal elimination half-life was 65hours, the terminal phase elimination rate constant was 0.011 h-1 , the mean residence time was 94h, and the area under the curve from time 0 to infinity was 14960 µg.h/ml. Conclusions: Our study concluded that the peak of the analgesic effect of alpha lipoic acid was one hour after treatment; furthermore, it is characterized by a long elimination half-life and a poor clearance from the chick’s body, which is reflected in the long effects of its pharmacological properties

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Section: Measuring the Pharmacokinetics Of Alpha-lipoic Acid In Chick...supporting

confidence: 92%

Estimation of pharmacokinetic parameters of alpha-lipoic acid in the chicks model

Abdulghani

Naser

2022

Baghdad J. Biochem. Appl. Biol. Sci.

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“…Reducing glucose and increasing total protein was also reported (Rehman et al, 2017). Murali et al (2013) fed chickens 900 mg/kg of L-carnitine and found that the treatment significantly reduced cholesterol and serum LDL-cholesterol levels compared to the control. The effect of L-carnitine on the levels of triglycerides, HDL, and VLDL was not significant.…”

Section: Applied Treatment Referencementioning

confidence: 73%

“…The results of this study showed that feed intake and feed conversion ratio increased with the application of L-carnitine compared to other treatments. Murali et al (2013) chickens. The results of this study showed that growth performance did not change under the influence of L-carnitine.…”

Section: Effect Of L-carnitine On the Perfor-mance Of Broiler Chickensmentioning

confidence: 99%

“…Live weight increase 40 mg/kg Kidd et al, 2009 Live weight increase and improved feed conversion ratio 1 ml /1.2 L Hrncar et al, 2015 Improved feed intake and increased weight in the first three grower weeks 50 mg/kg No significant effect on performance traits 25, 50, 75, 100 mg/kg Xu et al, 2003 No significant effect on performance traits 200 mg/kg Khajali and Khajali, 2014 No significant effect on performance traits and positive effect on ascites reduction 100 mg/kg Wang et al, 2013 Weight increase in grower period and whole period decreased feed intake and decreased feed conversion ratio in the finisher period 150, 300, 450 , 600 mg/kg Parsaeimehr et al, 2013 No significant effect on performance traits 100 mg/kg Shirali et al, 2015 Increased feed intake, weight gain increase, and reduced feed conversion ratio 125 mg/kg Rajabzadeh-Nesvan et al, 2013 No significant effect on performance traits 100 mg/kg Arslan and Tufan, 2018 Increased feed intake and reduced feed conversion ratio 250 mg/kg Rezaei et al, 2007 Bodyweight increase and carcass cooking performance 125 mg/kg Taraz and Dastar, 2008 Weight increase, feed intake decrease and no significant effect on the feed conversion ratio 100 , 200 mg/kg Kheirkhah et al, 2009 No significant effect on performance traits 50 mg/kg DarsiArani et al, 2010 Increasing weight and improving European production efficiency, decreasing feed consumption 375 mg/kg Akbari Azad et al, 2010 No significant effect on performance traits 125, 250 mg/kg Norreh et al, 2015 Improving live weight and feed conversion ratio in the grower and finisher periods 120 mg/kg Jalali et al, 2015 Live weight increase, improved feed consumption and feed conversion ratio 100 mg/kg Fallah et al, 2016 Improving performance 500, 1000 mg/kg Nouboukpo et al, 2010 Increased live weight, feed intake and improved feed conversion ratio 400, 600, 800 mg/kg MehdizadehTaklimi et al, 2015 Increased feed intake and improved feed conversion ratio 500 mg/kg Rehman et al,2017 No significant effect on performance traits 900 mg/kg Murali et al,2013 Decreased feed intake and improved feed conversion ratio 125 mg/kg+2 g Butyric acid Khatibjoo et al, 2016 No significant effect on performance traits 900 mg/kg Murali et al, 2015 Improved live weight, no significant effect on feed conversion ratio and water and feed consumption 500 mg/kg Increased live weight and decreased feed conversion ratio 200, 30...…”

Section: Applied Treatment Referencementioning

confidence: 99%

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Effects of L-carnitine supplementation in diets of broiler chickens

Azizi-Chekosari

Bouye

Seidavi

2021

J Hellenic Vet Med Soc

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L-carnitine is a nutritional supplement having fat-burning property and plays an important role in lipid metabolism, energy release, and also improve the production yield, immunity and blood constitute. This paper reviews the effects of L-carnitine on quantitative and qualitative characteristics of broilers. According to the reviewed literature, the application of L-carnitine (50-200 mg/kg) has no significant effect on the growth performance, however, using L-carnitine as much as 300-800 mg/kg resulted to an improvement in the body weight (2226.00-2575.00 g) compared to the control chicks (1998.40-2338.75 g). The feed conversion ratios of the chickens fed the same amount of L-carnitine were 1.66-1.86 kg/kg, which was improved in comparison with the control chicks (1.87-2.09 kg/kg). Abdominal fat of the broiler chickens fed 50-900 mg/kg L-carnitine was 0.98-1.75%, which is lower than the control chicks (1.79-2.16%). For immunity, the antibody titers against the Newcastle virus in the chickens fed 250 mg/kg L-carnitine was between 4.6- 5.5 which is more than control chicks (4.3-5.2). The antibody titer against the influenza virus in the chickens fed the same amount of L-carnitine was between 5.6-6.3, which was more than the control chicks (4.3-5.8). The use of 100-600 mg/kg L-carnitine could reduce triglyceride (90-104.4 mg/dL) compared to the control chicks (125-104.7 mg/dL) and also reduced the cholesterol (109-115 mg/dL) compared to the control chicks (129.25-131 mg/dL). The application of 100-600 mg/kg L-carnitine also could reduce low-density lipoprotein (LDL) from 19.1-72.2 mg/dL to 16.5-49.0 mg/dL. However, the application of 100-900 mg/kg L-carnitine had no significant effect on the sensory characteristics of broiler chicken meat. In general, it can be concluded that L-carnitine can be used as a dietary supplement on the health of broiler chickens without any negative effect on growth performance.

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“…The antioxidant properties of a-LA combined with the decrease in fat level in the a-LA treatment groups may have resulted in lipid peroxidation prevention, retarding development of off-flavors and improving lipid stability of meat-based products during storage [ 113 , 118 , 119 ]. Alpha-lipoic acid supplementation also improved growth performance in birds and the quality of poultry meat [ 117 , 118 , 119 , 120 , 121 , 122 , 123 ]. A recent study showed the effect of a-LA in improving semen quality in aged roosters [ 124 ].…”

Section: Effectiveness Of Alpha-lipoic Acid In Animalsmentioning

confidence: 99%

Alpha-Lipoic Acid as a Nutritive Supplement for Humans and Animals: An Overview of Its Use in Dog Food

Anthony

MacLeay

Gross

2021

Animals

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Alpha-lipoic acid (a-LA) is used as a nutritive additive in dog food. Therefore, we performed a systematic review of studies published to date in PubMed, Google Scholar, Cochrane Library and MedlinePlus involving alpha-lipoic acid supplementation, which included human clinical trials as well as animal studies, to evaluate its utility as a supplement in foods for healthy, adult dogs. While an upper limit of alpha-lipoic acid intake in humans has not been conclusively determined, the levels for oral intake of a-LA have been better defined in animals, and distinct differences based on species have been described. The maximum tolerated oral dose of a-LA in dogs has been reported as 126 mg/kg body weight and the LD50 as 400 to 500 mg/kg body weight. The antioxidant, anti-inflammatory and neuro-protective benefits of alpha-lipoic acid in dogs were observed at concentrations much lower than the maximum tolerated dose or proposed LD50. At concentrations of 2.7–4.94 mg/kg body weight/day, alpha-lipoic acid is well tolerated and posed no health risks to dogs while providing improved antioxidant capacity. This review thereby supports the utility of alpha-lipoic acid as an effective nutritive additive in dog food.

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Effect of dietary supplementation of l-carnitine on serum lipid profile and antioxidant status in broiler chicken fed with animal fat-rich diet

Cited by 8 publications

References 0 publications

Estimation of pharmacokinetic parameters of alpha-lipoic acid in the chicks model

Estimation of pharmacokinetic parameters of alpha-lipoic acid in the chicks model

Effects of L-carnitine supplementation in diets of broiler chickens

Alpha-Lipoic Acid as a Nutritive Supplement for Humans and Animals: An Overview of Its Use in Dog Food

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