Effect of dietary vitamin E and selenium on the phytohaemagglutinin response of pig lymphocytes

Larsen, H. J.; Tollersrud, Sverre

doi:10.1016/s0034-5288(18)32461-5

Cited by 72 publications

(19 citation statements)

References 19 publications

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“…These results confirmed previous reports on the altered ability of lymphocytes from a number of animal species to respond to mitogen stimulation following exposure to a Se-deficient or Sesupplemented diet (27)(28)(29)(30). These results confirmed previous reports on the altered ability of lymphocytes from a number of animal species to respond to mitogen stimulation following exposure to a Se-deficient or Sesupplemented diet (27)(28)(29)(30).…”

Section: Discussionsupporting

confidence: 91%

Selenium and Immune Cell Functions. I. Effect on Lymphocyte Proliferation and Production of Interleukin 1 and Interleukin 2

Kiremidjian-Schumacher

Roy

Wishe

et al. 1990

Experimental Biology and Medicine

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The dietary intake of selenium (Se) has been shown to influence the development and expression of various biologic processes. This study examined the immunologic competence of lymphocytes from C57BL/6J mice maintained for 8 weeks on Se-deficient (0.02 ppm Se), normal (0.20 ppm Se, as sodium selenite), or Se-supplemented (2.00 ppm Se) Torula yeast-based diets. The ability of the cells to recognize alloantigens, to proliferate in response to stimuli, and to produce interleukin 2 (IL-2) was determined. Se deficiency significantly inhibited the ability of the lymphocytes to proliferate in response to allogeneic stimulation in the mixed lymphocyte reaction or to mitogen stimulation by phytohemagglutinin, whereas Se supplementation significantly enhanced both responses. In contrast, the amounts of IL-2 and interleukin 1 (IL-1) produced by lymphocytes and macrophages, respectively, removed from Se-deficient or Se-supplemented animals did not differ significantly from the amounts of IL-2 and IL-1 produced by cells removed from animals maintained on the control diet. These results suggest that the mechanism(s) responsible for the observed effects of Se on lymphocyte proliferation are independent of the levels of IL-2 or IL-1.

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Section: Discussionsupporting

confidence: 91%

Selenium and Immune Cell Functions. I. Effect on Lymphocyte Proliferation and Production of Interleukin 1 and Interleukin 2

Kiremidjian-Schumacher

Roy

Wishe

et al. 1990

Experimental Biology and Medicine

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“…Previous studies showed that Se deficiency reduced T cell numbers and impaired lymphocyte proliferation in response to mitogen in pig, canine, and mouse [17,18], and T lymphocyte mitogenesis were increased after vitamin E and Se were amended in dietary in mouse and pig [10,19]. In the present study, the stimulating indexes of lymphocytes were lower in low-Se group than in control group, which means that low-Se diet decreased proliferative rates of peripheral blood lymphocytes.…”

Section: Discussionsupporting

confidence: 52%

“…Se deficiency reduced T cell numbers and impaired lymphocyte proliferation in response to mitogen [6,7]. Se supplementation had favorable effects on T cell responses, antibody synthesis [8,9], proliferative response to phytohemagglutinin [10], and intracellular killing of microbes [11].…”

mentioning

confidence: 99%

Low-Selenium Diet Induces Cell Cycle Arrest of Thymocytes and Alters Serum IL-2 Content in Chickens

Peng

Cui

Yuan

et al. 2011

Biol Trace Elem Res

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The purpose of this 42-day study was to investigate the effects of low selenium (Se) on cellular immune function by determining cell cycle of thymus, serum IL-2 content, and mitogenesis of peripheral blood T-lymphocytes. One hundred twenty 1-day-old Avian broilers were randomly assigned to two groups of 60 each and were fed on a low-Se diet (0.0342 mg/kg Se) or a control diet (0.2 mg/kg Se), respectively. Cell cycle analysis by flow cytometry showed that low-Se diet caused an increase in G(0)G(1) phase cells that corresponded to a decrease in S-phase cells in thymus. Ultrastructurally, mitochondria injury and increased apoptotic cells with condensed nuclei were observed. Low-Se diet decreased the serum IL-2 contents and mitogenesis of peripheral blood lymphocytes to concanavalin A in comparison with those of control group. These data indicate that low-Se diet inhibits the development of thymus by arresting the cell cycle and decreasing the IL-2 content.

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“…For example, IgM, IgG, and IgA titers were decreased in rats, and IgG and IgM titers were decreased in humans. Se supplementation had favorable effects on T cell responses, antibody synthesis [12][13][14][15], proliferative response to phytohemagglutinin [16], and intracellular killing of microbes [17,18]. Se was useful for the improvement of immune responses during disease [19].…”

mentioning

confidence: 99%

The Cell Cycle Arrest and Apoptosis of Bursa of Fabricius Induced by Low Selenium in Chickens

Peng

Cui

et al. 2010

Biol Trace Elem Res

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The purpose of this 42-day study was to investigate the effects of low selenium (Se) on immune function by determining cell cycle and apoptosis of bursa of Fabricius. One hundred twenty 1-day-old avian broilers were randomly assigned to two groups of 60 each and were fed on a low Se diet (0.0342 mg/kg Se) or a control diet (0.2 mg/kg Se), respectively. The relative weight of bursa was significantly decreased in low Se group from 28 days of age in time-dependent manner when compared with that of control group. Cell cycle analysis by flow cytometry showed that low Se caused an increase in G₀G₁ phase cells that corresponded to a decrease in S phase cells in bursa of Fabricius. Ultrastructurally, mitochondria injury and increased apoptotic cells with condensed nuclei were observed. Low Se increased the percentage of Annexin V-positive cells, as measured by flow cytometry, in comparison with that of control group. These data suggested that low Se diet restrained the development of bursa of Fabricius by cell cycle arrest and apoptosis.

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Effect of dietary vitamin E and selenium on the phytohaemagglutinin response of pig lymphocytes

Cited by 72 publications

References 19 publications

Selenium and Immune Cell Functions. I. Effect on Lymphocyte Proliferation and Production of Interleukin 1 and Interleukin 2

Selenium and Immune Cell Functions. I. Effect on Lymphocyte Proliferation and Production of Interleukin 1 and Interleukin 2

Low-Selenium Diet Induces Cell Cycle Arrest of Thymocytes and Alters Serum IL-2 Content in Chickens

The Cell Cycle Arrest and Apoptosis of Bursa of Fabricius Induced by Low Selenium in Chickens

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