Effect of Dietary Vitamin E Supplementation on Murine Nasal Allergy

Zheng, Kui; Shinjo, Masaki; Todoriki, Hidemi; Ariizumi, Makoto; Shinjo, Sumie; Adjei, Andrew A.

doi:10.1016/s0002-9629(15)40572-5

Cited by 22 publications

(14 citation statements)

References 45 publications

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“…Similar results have been observed in mouse models supplemented with vitamin E before primary sensitization [50]. Supplementation with vitamin E before primary sensitization in the murine model of toluene-diisocyanate (TDI) induced nasal allergy, significantly attenuated the outwardly observable indicators of nasal allergy, and reduced mitogen-induced lymphoproliferative, IL-4 and IL-5 responses [51]. Similar results have been reported in nasally TDI sensitized guinea-pigs supplemented with vitamin E and C [52].…”

Section: Animal Modelssupporting

confidence: 80%

Antioxidants and allergic disease: a case of too little or too much?

Allan

Kelly

Devereux

2010

Clin Experimental Allergy

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Speculation persists as to the possible role, if any, of dietary antioxidants in allergic disease. While it has been hypothesized that the recent increase in allergic disease is a consequence of declining dietary antioxidant intake, an alternative hypothesis proposes that the increase in allergic disease is due to increasing antioxidant intake. Dietary trends are conflicting; the intake of some antioxidants has declined, for others intakes are likely to have increased. Animal model studies demonstrate that antioxidant supplementation at the time of primary and subsequent allergen exposure attenuates allergic inflammatory responses. The data from human studies are less clear. Observational epidemiological studies of humans are beset by several methodological limitations associated with the assessment of diet and predominantly focus on asthma. Most observational studies report potentially beneficial associations between dietary antioxidants and allergic outcomes, but a small minority report potentially adverse associations. Human intervention studies suggest that single antioxidant supplements confer minimal, if any clinical benefit in adults with asthma, however, there is still scope for studies in children, atopic dermatitis, allergic rhinitis (AR) and of antioxidant combinations. More recently, it has been suggested that dietary antioxidants in the developmental context of fetal and infant development influence the development childhood asthma and atopic sensitization possibly by affecting the first interactions between the neonatal immune system and allergens. While a small number of birth cohort studies have reported potentially beneficial associations between maternal intake of some antioxidants during pregnancy and childhood asthma, there is very limited data suggesting associations between maternal antioxidant intake and childhood atopic dermatitis and AR. The available epidemiological, animal, molecular and immunological data suggest that there are associations between antioxidants and asthma and to a much lesser extent, atopic dermatitis and AR. However, the exact nature of the relationships and the potential for therapeutic intervention remain unclear.

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Section: Animal Modelssupporting

confidence: 80%

Antioxidants and allergic disease: a case of too little or too much?

Allan

Kelly

Devereux

2010

Clin Experimental Allergy

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“…Since it has been reported that vitamin E did not down‐regulate IL‐2 levels in a mouse allergy model 16 but instead even restored IL‐2 levels reduced during retrovirus infection in murine AIDS models 15, 19 and increased IL‐2 production in old mice 20 and healthy older adults 21, we also examined the effect of vitamin E on IL‐2 mRNA levels by quantitative real‐time PCR. The IL‐2 mRNA expression levels were much higher (more than 100‐fold) than the levels of IL‐4 mRNA (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, a study on the relation between dietary vitamin E intake and serum IgE concentrations and atopy, from a random sample of 2,633 adults, revealed that higher concentrations of vitamin E (but not vitamin C) intake were associated with lower serum IgE levels and a lower frequency of allergen sensitization 14. Significant reduction of IgE and IL‐4 levels was also observed in mice whose diet was supplemented with vitamin E 15, 16. Although the effect of vitamin E on IgE and atopy has been reported, the molecular mechanism by which vitamin E suppresses IgE expression has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Vitamin E inhibits IL-4 gene expression in peripheral blood T cells

et al. 2002

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IL‐4 plays a pivotal role in the development of allergic inflammation via induction of IgE isotype switching, increase of IgE receptor expression, promoting Th2 cell differentiation, and stimulating several genes involved in atopic disorders. Previous studies in human and mouse models have shown that high vitamin E intake correlates with low IgE concentration and reduced prevalence of allergic reactions. We, therefore, investigated the mechanism of the vitamin E effect on T cells. We show here that the natural free radical scavenger vitamin E suppresses IL‐4 protein levels in humanperipheral blood T cells in a dose‐dependent manner. The effect of vitamin E on IL‐4 expression occurs at the mRNA level. Vitamin E has been implicated in inhibition of DNA binding and function of the redox‐regulated transcription factors NF‐κB and AP‐1. Investigation of the molecular mechanism by which vitamin E suppresses IL‐4 transcription shows that it blocks binding of transcription factors to two important IL‐4 promoter binding sites for NF‐κB and AP‐1 and interferes with promoter activity upon T cell activation. Our data provide molecular evidence supporting the beneficial effect of dietary vitamin E on atopic disorders.

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“…In a murine nasal allergy model, Zheng et al showed that supplementation with a diet containing 535 mg aT per kg for 4 weeks significantly reduced quantifiable nasal symptoms compared with a diet containing normal levels of aT (Zheng et al, 1999). In contrast to the human studies discussed before aT supplementation also led to a significant decrease in lymphocyte proliferation, serum IgE levels and production of the Th2 cytokines IL-4 and IL-5 in these animals.…”

Section: Animal Studiesmentioning

confidence: 99%

Anti-inflammatory properties of α- and γ-tocopherol

Reiter

Jiang

Christen

2007

Molecular Aspects of Medicine

259

166

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Natural vitamin E consists of four different tocopherol and four different tocotrienol homologues (alpha,beta, gamma, delta) that all have antioxidant activity. However, recent data indicate that the different vitamin E homologues also have biological activity unrelated to their antioxidant activity. In this review, we discuss the anti-inflammatory properties of the two major forms of vitamin E, alpha-tocopherol (alphaT) and gamma-tocopherol (gammaT), and discuss the potential molecular mechanisms involved in these effects. While both tocopherols exhibit anti-inflammatory activity in vitro and in vivo, supplementation with mixed (gammaT-enriched) tocopherols seems to be more potent than supplementation with alphaT alone. This may explain the mostly negative outcomes of the recent large-scale interventional chronic disease prevention trials with alphaT only and thus warrants further investigation.

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Effect of Dietary Vitamin E Supplementation on Murine Nasal Allergy

Cited by 22 publications

References 45 publications

Antioxidants and allergic disease: a case of too little or too much?

Antioxidants and allergic disease: a case of too little or too much?

Vitamin E inhibits IL-4 gene expression in peripheral blood T cells

Anti-inflammatory properties of α- and γ-tocopherol

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