Effect of different carboxylic acids as solvent on chitosan fibers production by wet spinning

Cruz, Rita de Cássia Alves Leal; Diniz, Luana Geovanna Marques; Oliveira, Hugo Miguel Lisboa; Fook, Marcus Vinícius Lia

doi:10.1590/s1517-707620160002.0049

Cited by 9 publications

(15 citation statements)

References 12 publications

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“…The polymer solution was maintained under constant mechanical stirring at 600 rpm, at room temperature (25 ± 1 °C) for 2 h. After that, the GlcNAc (0.2 g) was added slowly to the chitosan solution (100 mL) by continuous stirring, which was maintained for 30 min at 600 rpm. The CS/GlcNAc solution was transferred to a syringe (20 mL capacity and 1 mm diameter outlet tip) and then pumped into the coagulation bath (300 mL—70% aqueous solution of 1M NaOH and 30% methanol; pH 13) [44] at a fixed flow rate (45 mL/h) [45] using a syringe pump (Pump 11 Pico Plus Elite, Harvard Apparatus, Holliston, MA, USA). The filaments formed immediately and entangled randomLy.…”

Section: Methodsmentioning

confidence: 99%

N-Acetyl-D-Glucosamine-Loaded Chitosan Filaments Biodegradable and Biocompatible for Use as Absorbable Surgical Suture Materials

Silva

Cruz

et al. 2019

Materials

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The aim of this study was to prepare chitosan (CS) filaments incorporated with N-acetyl-D-Glucosamine (GlcNAc), using the wet spinning method, in order to combine the GlcNAc pharmacological properties with the CS biological properties for use as absorbable suture materials. The filaments were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), uniaxial tensile testing, in vitro biodegradation, and through in vitro drug release and cytotoxicity studies. It was observed that the addition of GlcNAc did not alter the morphology of the filaments. The CS and CS/GlcNAc filaments presented diameters 145 µm and 148 µm, respectively, and the surfaces were homogeneous. Although the mechanical resistance of the chitosan filaments decreased with the incorporation of the GlcNAc drug, this property was greater than the mean values indicated in the U.S. Pharmacopeia (1.7 N) for suture number 6-0 (filament diameter of 100–149 μm). The biodegradation of the CS filaments was accelerated by the addition of GlcNAc. After 35 days, the CS/GlcNAc filaments degradability was at its total, and for the CS filaments it was acquired in 49 days. The in vitro kinetic of the release process was of the zero-order and Hopfenberg models, controlled by both diffusion and erosion process. The in vitro cytotoxicity data of the CS and CS/GlcNAc filaments toward L929 cells showed that these filaments are nontoxic to these cells. Thus, the GlcNAc-loaded CS filaments might be promising as absorbable suture materials. In addition, this medical device may be able to enhance healing processes, relieve pain, and minimize infection at the surgery site due the prolonged release of GlcNAc.

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Section: Methodsmentioning

confidence: 99%

N-Acetyl-D-Glucosamine-Loaded Chitosan Filaments Biodegradable and Biocompatible for Use as Absorbable Surgical Suture Materials

Silva

Cruz

et al. 2019

Materials

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“…The images confirm that H 2 SO 4 could be used as a part of an effective coagulation bath, contributing to fibers with a smooth and uniform surface. As reported earlier [ 29 ], the presence of small white particles noticed on some monofilaments (e.g., [LA]-[H 2 SO 4 -EtOH]-[N]) stems from NaOH contamination from the coagulation bath, which was not removed in the washing process. Figure 2 c represents the fibers with the highest tensile strength obtained using lactic acid, citric acid, and acetic acid, respectively (c.f.…”

Section: Resultsmentioning

confidence: 78%

New Solvent and Coagulating Agent for Development of Chitosan Fibers by Wet Spinning

et al. 2021

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Adipic acid was evaluated as a novel solvent for wet spinning of chitosan fibers. A solvent with two carboxyl groups could act as a physical crosslinker between the chitosan chains, resulting in improved properties of the fibers. The performance of adipic acid was compared with conventional solvents, i.e., lactic, citric, and acetic acids. Chitosan solutions were injected into a coagulation bath to form monofilaments. Sodium hydroxide (NaOH) and its mixture with ethanol (EtOH) were used as coagulation agents. Scanning electron microscopy confirmed the formation of uniform chitosan monofilaments with an even surface when using adipic acid as solvent. These monofilaments generally showed higher mechanical strength compared to that of monofilaments produced using conventional solvents. The highest Young’s modulus, 4.45 GPa, was recorded for adipic acid monofilaments coagulated in NaOH-EtOH. This monofilament also had a high tensile strength of 147.9 MPa. Furthermore, taking advantage of chitosan insolubility in sulfuric acid (H2SO4) at room temperature, chitosan fibers were successfully formed upon coagulation in H2SO4-EtOH. The dewatering of fibers using EtOH before drying resulted in a larger fiber diameter and lower mechanical strength. Adipic acid fibers made without dehydration illustrated 18% (for NaOH), 46% (for NaOH-EtOH), and 91% (for H2SO4-EtOH) higher tensile strength compared to those made with dehydration.

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“…The following substances were used in the study. Chitosan -poly ((1,4)-2-amino-2deoxy)-β-D-glucose, as such, obtained from crab shells (OJSC "Bioprogress", Moscow, Russia) with different MW -1.10×10 5 , DD = 0.82 and 2.20×10 5 , DD = 0.82.…”

Section: Methodsmentioning

confidence: 99%

“…Conformational transitions of chitosan were established by the spectrophotometric method. For the analysis, 0.03 wt% aqueous solutions of chitosan in hydrochloric acid with MW of the polymer 2.2×10 5 and 1.0×10 5 were prepared. The readings of pH-meter Mettler Toledo LE902 ranging from 3.3 to 6.0 were recorded, and the transmittance spectra of the solutions were registered by the IR and visible spectrophotometer UV-1650 (Shimadzu) during the introduction of some amount of 2.5% NaOH solution.…”

Section: Dynamic Viscosity Of Chitosan Solutions Was Measured By Rotational Viscosimetermentioning

confidence: 99%

“…It provides mechanical strength, steadily degrades facilitating the growth of new tissue, and acts as a cellular and molecular scaffold for the migration and cultivation of the required cells (Lian et al, 2009;Ilbasmis-Tamer et al, 2017;Ribeiro et al, 2017). There are studies on the application of polysaccharides for the production of new biodegradable suture material (Cruz et al, 2016;Li and Tang, 2016). Chitosan is used as a substance that contributes to weight loss and improves cholesterol metabolism and intestinal motility (Tuma et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Conformational Conditions of Chitosan Macromolecules and Their Influence on the Efficiency of Chitosan Polymerization Process With 2-Hydroxyethyl Methacrylate and N-Vinylpyrrolidone

Apryatina¹,

Tkachuk²,

Смирнова³

2020

PTQ

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Modification of chitosan with biocompatible synthetic polymers is important for the development of biodegradable medical materials with a tailor-made complex of properties. The issue of the influence of a polysaccharide macromolecule conformation on the synthesis and properties of the hybrid products remains acute. Conformational transitions of chitosan and their influence on the process of grafted polymerization of 2-hydroxyethyl methacrylate and N-vinylpyrrolidone onto the polymer and the properties of their copolymers were studied. To interpret the peculiarities of chitosan solutions properties, their viscosity was identified by the method of rotational viscometry; conformational transitions of the polymer polysaccharides were investigated by the method of spectrophotometry; dimensional characteristics of the polymer particles were assessed by the method of dynamic light scattering. Copolymers were characterized by the methods of IR-spectroscopy and gelpenetrating chromatography. Helix-coil conformational transition of the chitosan macromolecule was pH and temperature-sensitive. The effective size of the chitosan macromolecules for helix conformation was 14-35% larger than for the coil conformation. The grafted copolymer yield (98%) was significantly higher in the solutions of chitosan, where its macromolecules were in the coil conformation. The obtained results allow the researchers to create optimal conditions during the development of the copolymer-based biomedical materials with improved characteristics.

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Effect of different carboxylic acids as solvent on chitosan fibers production by wet spinning

Cited by 9 publications

References 12 publications

N-Acetyl-D-Glucosamine-Loaded Chitosan Filaments Biodegradable and Biocompatible for Use as Absorbable Surgical Suture Materials

N-Acetyl-D-Glucosamine-Loaded Chitosan Filaments Biodegradable and Biocompatible for Use as Absorbable Surgical Suture Materials

New Solvent and Coagulating Agent for Development of Chitosan Fibers by Wet Spinning

Conformational Conditions of Chitosan Macromolecules and Their Influence on the Efficiency of Chitosan Polymerization Process With 2-Hydroxyethyl Methacrylate and N-Vinylpyrrolidone

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