Effect of Different Concentrations of Red Palm Olein and Different Vegetable Oils on Antioxidant Enzymes in Normal and Stressed Rat

Dauqan, Eqbal; Abdullah, Aminah; Sani, Halimah Abdullah

doi:10.5772/48272

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…This result confirms that VCO treatment has best immunomodulation response in rats when VCO was given before S. aureus infection. Dauqan et al (2012) reported that the activity of SOD of coconut oil increased from week 4 and remained high until week 8. The coconut oil appear to have highest activity of SOD compared to both palm oil and corn oil.…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory Effect of Virgin Coconut Oil in Wistar Rats Infected with Staphylococcus aureus

Widianingrum

Salasia

2021

JITV

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Virgin coconut oil (VCO) contains bioactive that induce immunity against infectious diseases. This study aim to determine the immunomodulatory effects of VCO based on the activity of superoxide dismutase (SOD), lymphocyte proliferation, and histopathological examination in liver and kidney of rats infected with Staphylococcus aureus. The VCO was given intragastrically to rats with a dose of 250 µL for one week. The rats were infected with S. aureus at 5x102 bacterial cells intraperitoneally. Twenty (20) female Wistar rats of one month old were divided into four groups. The negative control group (C-): without treatment, AV group: infected with S. aureus followed by VCO treatment; VA group: pretreated with VCO followed by S. aureus infection, and positive control group (C+): were infected with S. aureus without VCO. All rats were euthanized and necropsied based on the animal ethic standard. Plasma samples were taken to evaluate SOD activity, and lymphocytes were isolated from the spleen to determine their proliferative ability. Livers and kidneys were collected for a histopathology examination. Results showed that the VA group had the highest SOD activity on the 4th week (41.50 ± 3.56 %) and lymphocyte proliferation (0.3018) compared to all treatments, indicating immunomodulatory effects of VCO. Liver of treatments group showed leucocytes infiltration, no hemorrhages (VA); the hepatocytes with normal cells (VA). Kidney of treatments group showed leucocytes infiltration (AV); normal epithelial glomerulus and tubulus cells, still found hemorrhage (VA). These studies indicated that VCO has a potential role as an immunomodulator, hepatoprotectant, and nephroprotectant.

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Section: Resultsmentioning

confidence: 99%

Immunomodulatory Effect of Virgin Coconut Oil in Wistar Rats Infected with Staphylococcus aureus

Widianingrum

Salasia

2021

JITV

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“…Antioxidant-rich RPO is beneficial to SHR in these studies; however, the research for humans effect is still 17,45 . The vitamin E tocotrienols and carotenoids of RPO both can act as antioxidants that play a significant role in maintaining the immunity of the human body 46 . Chemotherapy and radiation therapy are some of the treatments available for cancer; however, it will generate reactive oxygen series ROS that will induce DNA damage 47 .…”

Section: Increase Antioxidant Level and Reduce Risk Of Cancermentioning

confidence: 99%

Red Palm Oil: A Review on Processing, Health Benefits and Its Application in Food

et al. 2021

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IntroductionOil palm, Elaeis guineensis, has been cultivated in Malaysia since 1917 and is now the most important economic crop in Malaysia, with export revenue from the crop reaching more than RM 67.12 billion in 2018 1 . Other leading palm oil-producing countries are Indonesia and Thailand. The crop produces almost ten times higher oil per hectare than any other leading vegetable oil crops 2 . Palm oil and its derivatives are mainly used for cooking, frying oils, margarine, shortenings, vanaspati and specialty fats 3 . Palm oil or its blends with with palm kernel or with other vegetable oils were the different product available in market.Crude palm oil is extracted from palm mesocarp and rich in minor components, including carotenoids precursor of vitamin A , tocopherols and tocotrienols vitamin E , sterols, phospholipids, squalene, aliphatic hydrocarbons and aliphatic alcohols 4 . More research has been focusing on carotenoids and vitamin E in palm oil in recent years with its antioxidant properties. Despite their nutritional values, palm carotenoids are removed during the refining process, this is to gain clear oil which is better for consumer acceptance and industry purposes 5 . The concentration of carotenoids is reduced to more than half with application of high temperature and steps such as deacidification and deodorization. Goh et al. stated that tocopherols level

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Pengaruh Pemberian Diet Tinggi Minyak Sawit terhadap Kadar Malondialdehid Darah Tikus Wistar

Eszy¹,

Sastri²,

Masri³

2014

JKA

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AbstrakMinyak sawit merupakan sumber lemak yang banyak dikonsumsi oleh masyarakat Indonesia. Minyak ini mengandung 50% asam lemak jenuh atau saturated fatty acid (SFA), 40% asam lemak tidak jenuh rantai tunggal atau Monounsaturated Fatty Acid (MUFA),10% asam lemak tidak jenuh rantai ganda atau Polyunsaturated Fatty Acid (PUFA), antioksidan, vitamin E dan beta-karoten. Rasio asam lemak jenuh dan asam lemak tidak jenuh pada minyak sawit hampir sama. Komposisi asam lemak dan antioksidan berperan dalam menentukan pembentukan ROS (Reactive Oxygen Species) di jaringan tubuh. Tujuan penelitian ini adalah untuk mengetahui pengaruh diet tinggi minyak sawit terhadap kadar Malondialdehid (MDA) darah tikus. Penelitian ini merupakan suatu studi eksperimental dengan menggunakan post test only control group design. Sampel terdiri dari sepuluh ekor tikus wistar jantan dengan berat antara 180-260 gram yang dibagi menjadi dua kelompok, yaitu kelompok tikus control yang diberi diet standar ad libitum dan kelompok tikus perlakuan yang diberi tambahan minyak sawit kedalam diet standar ad libitum. Setelah perlakuan satu bulan, dilakukan pemeriksaan kadar malondialdehid. Hasil penelitian menunjukkan terdapat perbedaan yang signifikan (p<0,05) antara kadar MDA kelompok tikus perlakuan (2,494±0,504 nmol/ml) dengan kelompok tikus kontrol (3,152±0,237 nmol/ml). Dari hasil penelitian ini dapat disimpulkan bahwa diet tinggi minyak sawit menurunkan kadar MDA darah tikus.Kata kunci: minyak sawit, SFA, MUFA, antioxidant, ROS, MDAAbstractPalm oil is a source of fat which most widely consumed by Indonesian people. This oil contains 50% Saturated Fatty Acid (SFA), 40% Monounsaturated Fatty Acid (MUFA), 10% Polyunsaturated Fatty Acid (PUFA), antioxidant, vitamin E and beta-carotene. The saturated fatty acid to unsaturated fatty acid ratio of palm oil is almost same. Composition offatty acids and antioxidants play a role in determining the production of ROS (Reactive Oxygen Species) in the tissues of the body. This study was aimed to assess the effect of a high palm oil diet on malondialdehyde (MDA) concentration in rat’s blood. This research was an experimental study which applies post test only control group design. Sample amounted to ten male wistar rats with 180-260 gram weight were divided into two research groups those are control group rats which were administrated standard diet ad libitum and treatment group rats which were administrated addition of palm oil to standar diet ad libitum. After one month treatment, malondialdehyde concentrations were observed. The result of this study revealed significant defference (p<0.05) between MDA concentration in treatment group rats (2.494±0.504 nmol/ml) and control group rats (3.152±0.237 nmol/ml). From the result of this research may be concluded that high palm oil diet decreased MDA concentration of rat’s blood.Keywords: palm oil, SFA, MUFA, antioxidant, ROS, MDA

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Effect of Different Concentrations of Red Palm Olein and Different Vegetable Oils on Antioxidant Enzymes in Normal and Stressed Rat

Cited by 3 publications

References 24 publications

Immunomodulatory Effect of Virgin Coconut Oil in Wistar Rats Infected with Staphylococcus aureus

Immunomodulatory Effect of Virgin Coconut Oil in Wistar Rats Infected with Staphylococcus aureus

Red Palm Oil: A Review on Processing, Health Benefits and Its Application in Food

Pengaruh Pemberian Diet Tinggi Minyak Sawit terhadap Kadar Malondialdehid Darah Tikus Wistar

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