Effect of Different Dietary Energy Sources on Induction of Fatty
Liver-Hemorrhagic Syndrome in Laying Hens

Zhang, Jinwei; Chen, Shuai; Yu, Bing

doi:10.3923/ijps.2008.1232.1236

Cited by 27 publications

(30 citation statements)

References 11 publications

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“…Based on the findings of the present study, the administration of at least 4.0 g kg −1 CRP might markedly improve liver health indices in laying hens. Histological examination revealed that the staining density of liver samples in birds receiving high‐energy diets was lower than that in controls, which is in line with the study by Zhang et al reporting that high‐energy diets might deliver high levels of fatty acids to the liver and then increase the probability of lipo‐peroxidation and fatty liver syndrome.…”

Section: Discussionsupporting

confidence: 88%

“…One of the nutritional strategies aiming to optimize lying hen performance comprises an increased dietary energy level. Any restriction of energy intake could significantly decrease egg production, although increasing dietary energy, especially from fat or oil sources, may be associated with detrimental effects on serum biochemical variables such as hepatic enzyme activities and lipid constitutes . Han et al demonstrated that increasing dietary lipid concentrations with the aim of increasing the energy level also elevated liver, serum and egg yolk cholesterol, which represents an undesirable outcome for human nutrition; however, it might be a profitable way of improving the productive performance of laying hens.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Curcuma longa rhizome powder on egg quality, performance and some physiological indices of laying hens fed different levels of metabolizable energy

et al. 2016

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Effects of Curcuma longa rhizome powder on egg quality, performance and some physiological indices of laying hens fed different levels of metabolizable energy

et al. 2016

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“…; Zhang et al . ). It was thought high‐energy intake caused increased fatty acids in plasma, furthering an elevated level of lipogenesis in the liver, which leads to lipid accumulation (mainly TG) in the liver and then the occurrence of FLHS (Whitehead ).…”

Section: Discussionmentioning

confidence: 97%

“…; Zhang et al . ). Squires and Wu () demonstrated that hepatic lipid peroxidation occurred in the single comb White Leghorn birds susceptible to FLHS and had a higher MDA liver content.…”

Section: Discussionmentioning

confidence: 97%

Improving effect of dietary soybean phospholipids supplement on hepatic and serum indexes relevant to fatty liver hemorrhagic syndrome in laying hens

Yang

Ruan

Wang

et al. 2017

Animal Science Journal

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In order to investigate the effect of dietary soybean phospholipid supplement on hepatic and serum indexes relevant to fatty liver hemorrhagic syndrome (FLHS) in layers, 135 300-day-old Hyline Brown layers were randomly divided into three groups (control, pathology and prevention), and each group had 45 layers with three replicates. Birds in the three groups were respectively fed the control diet, high-energy low-protein diet and high-energy high-protein diet affixed with 3% soybean phospholipid instead of maize. Results showed in the 30th day, birds' livers in the pathology group became yellowish, enlarged in size and had hemorrhagic spots, while the prevention and control groups' layers did not have such pathological changes. Contents of triglyceride, total cholesterol, low-density lipoprotein - cholesterol, non-esterified fatty acid and malondialdehyde in serum or liver homogenate in prevention and control groups were remarkably lower than those in the pathology group (P < 0.05 or P < 0.01), as with the activities of glutamic oxalacetic transaminase and glutamic-pyruvic transaminase (P < 0.01); high-density lipoprotein - cholesterol value was strikingly higher than that of the pathology group (P < 0.01). It is suggested dietary soybean phospholipids supplement may effectively improve hepatic and blood indexes relevant to FLHS, which provides a new point for preventing FLHS occurrence rate in laying flocks and treating human non-alcohol fatty liver disease.

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“…It is associated with approximately 40% of the necropsied hens, and can be up to 74% in the caged laying hens [2]. Several factors have been relate to FLSH, such as nutritional, metabolic, hormonal, environmental, and genetic factors [1,2], but excess energy intake is the fundamental player as FLHS can be induced by a high-fat diet (HFD) [4][5][6][7][8] or a high fat and low protein (HFLP) diet [1,[9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Osteocalcin prevents insulin resistance, hepatic inflammation and autophagy associated with high-fat diet induced fatty liver hemorrhagic syndrome in aged laying hens

Zou

et al. 2020

Preprint

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Background: Osteocalcin (OCN), as an energy-regulating hormone, involves in preventing nonalcoholic steatohepatitis. Laying hens have been used as an animal model for investigating liver function and related metabolic disordersas that the synthesis of fat in laying hens is much faster than in mammals with limited adipose tissue. The aim of this study was to investigate the effects of OCN on fatty liver hemorrhagic syndrome (FLHS) in aged laying hens. Methods: Thirty 68-week-old White Plymouth laying hens were randomly assigned into conventional single-bird cages, and the cages were randomly allocated into one of three treatments: normal diet (ND + vehicle , ND+V), high-fat diet (HFD + vehicle, HFD+V), and HFD + OCN (3 μg/bird, 1 time/2 days, i.m.) for 40 days. At experimental day 30, oral glucose tolerance tests (OGTT) and insulin tolerance tests (ITT) were performed. At the end of experiment, the hens were euthanized followed blood collection. The plasma aspartate transaminase (AST), alkaline phosphatase (ALP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured using an automatic biochemistry analyzer. Pathological changes in the liver were examined under both light and transmission electron microscopes. The plasma inflammatory factors including interleukin-1 (IL-1), IL-6, and tumor Necrosis Factor-alpha (TNF-α) were analyzed by ELISA, and the gene expressions of these inflammatory factors in the liver were analyzed by Real-time PCR. And oxidative stress was evaluated using Malondialdehyde (MDA) and Glutathione peroxidase (GSH-Px) assay kits. Results: The results showed HFD hens had more severe liver haemorrhage and fibrosis than ND hens. The ultra-microstructural examination showed that hepatocytes of HFD hens appeared necrotic pyknosis associated with great intracellular electron, mitochondrial swelling, shrunk nucleus and absence of autolysosomes. OCN mitigated these pathological changes by improved HFD hens’ insulin resistance via alleviating the glucose intolerence and improving insulin sensitivity; inhibited HFD-induced oxidative stress as evidenced by decreased liver concentrations of MDA but increased GSH-Px; and reduced the inflammatory reaction with reducing blood IL-6 and TNF-α concentrations and mRNA expressions. Conclusion: These results suggest a high-fat diet promotes the FLHS development in aged hens, while OCN prevents the FLHS process through inhibiting insulin resistance, inflammatory reaction, oxidative stress and fibrosis, and acting autophagy.

show abstract

Effect of Different Dietary Energy Sources on Induction of Fatty Liver-Hemorrhagic Syndrome in Laying Hens

Cited by 27 publications

References 11 publications

Effects of Curcuma longa rhizome powder on egg quality, performance and some physiological indices of laying hens fed different levels of metabolizable energy

Effects of Curcuma longa rhizome powder on egg quality, performance and some physiological indices of laying hens fed different levels of metabolizable energy

Improving effect of dietary soybean phospholipids supplement on hepatic and serum indexes relevant to fatty liver hemorrhagic syndrome in laying hens

Osteocalcin prevents insulin resistance, hepatic inflammation and autophagy associated with high-fat diet induced fatty liver hemorrhagic syndrome in aged laying hens

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