Effect of different dietary zinc levels on hepatic antioxidant and micronutrients indices under oxidative stress conditions

Tupe, Rashmi S.; Tupe, Santosh G.; Tarwadi, Kirtan; Agte, Vaishali

doi:10.1016/j.metabol.2010.02.020

Cited by 29 publications

(24 citation statements)

References 52 publications

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“…Zinc has a variety of effects on biological activities that might explain this hepatoprotective action. These are the following: (1) Zinc stabilizes membranes and inhibits lipid peroxidation; (2) Zinc induces hepatic MT, which is rich in SH groups and binds certain toxic metals; (3) Zinc is required for P450 activity, which is important in toxic drug metabolism; (4) Zinc improves the protein synthesis function of liver; and (5) the hepatoprotective action of zinc administration against oxidative stress was imposed through the regulation of the metabolism of superoxide dismutase, MT and reduced glutathione [27,28]. Liver disease, especially alcoholic liver disease, has been associated with hypozincemia and zinc deficiency [29].…”

Section: Discussionmentioning

confidence: 99%

Psychological stress induced zinc accumulation and up-regulation of ZIP14 and metallothionein in rat liver

Xue

Zheng

et al. 2014

BMC Gastroenterol

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BackgroundZinc is necessary for normal liver function; and vice versa, the liver plays a central role in zinc homeostasis. The aim of present study is to assess the effects of repeated psychological stress (PS) on the zinc metabolism and related mechanism involved in zinc homeostasis in rat liver.MethodsIn present study, we used communication box to create PS model and investigated the serum corticosterone (CORT), zinc level in serum and liver, liver metallothionein (MT) content and ZRT/IRT-like Protein 14 (ZIP14) mRNA expression.ResultsThe results showed that the serum CORT level increased and serum zinc level decreased significantly after 7 d and 14 d PS treatment. Meanwhile, zinc and MT contents in liver were elevated after 14 d PS exposure, while those in 7 d PS exposure group did not change. ZIP14 mRNA was expressed markedly at 7 d after the onset of PS, while Zip14 mRNA expression in the liver after 14 d PS exposure reached normal level compared with control group.ConclusionsThe results suggest that PS exposure could induce hypozincemia, which might be related to liver zinc accumulation because of high level of MT through glucocorticoid-mediated MT synthesis and ZIP14 expression induced by interleukin-6.

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Section: Discussionmentioning

confidence: 99%

Psychological stress induced zinc accumulation and up-regulation of ZIP14 and metallothionein in rat liver

Xue

Zheng

et al. 2014

BMC Gastroenterol

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“…Because Zn controls metallothionein expression it is involved in cellular redox regulation [91,92]. Oxidative stress can be corrected by dietary Zn as demonstrated by an elevation of hepatic antioxidant enzymes [93]. In contrast, a recent study showed that in vitro even micromolar concentrations were cytotoxic under prevailing H2O2-induced oxidative stress [94].…”

Section: Zincmentioning

confidence: 99%

Trace elements in glucometabolic disorders: an update

Wiernsperger

Rapin

2010

Diabetol Metab Syndr

140

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Many trace elements, among which metals, are indispensable for proper functioning of a myriad of biochemical reactions, more particularly as enzyme cofactors. This is particularly true for the vast set of processes involved in regulation of glucose homeostasis, being it in glucose metabolism itself or in hormonal control, especially insulin. The role and importance of trace elements such as chromium, zinc, selenium, lithium and vanadium are much less evident and subjected to chronic debate. This review updates our actual knowledge concerning these five trace elements. A careful survey of the literature shows that while theoretical postulates from some key roles of these elements had led to real hopes for therapy of insulin resistance and diabetes, the limited experience based on available data indicates that beneficial effects and use of most of them are subjected to caution, given the narrow window between safe and unsafe doses. Clear therapeutic benefit in these pathologies is presently doubtful but some data indicate that these metals may have a clinical interest in patients presenting deficiencies in individual metal levels. The same holds true for an association of some trace elements such as chromium or zinc with oral antidiabetics. However, this area is essentially unexplored in adequate clinical trials, which are worth being performed.

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“…Chronic blood transfusion in major thalassemia or other hemolytic disorders such as Sickle cell anemia may decrease chronic hemolysis and change the micronutrient status (6-8). Zinc is a trace element involved in synthesis of many other properties such as cholesterol, fat and more than 300 enzymes and immune and antioxidant system (9, 10). Zinc has essential role in red blood cell survival and zinc deficiency leads to membrane fragility (11).…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Zinc Deficiency in Patients With Thalassemia in South East of Iran, Sistan and Baluchistan Province

Mashhadi¹,

Sepehri²,

Heidari³

et al. 2014

Iran Red Crescent Med J

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Background:There are different and controversial reports about zinc deficiency in patients with major thalassemia.Objectives:The aim of this study was to evaluate zinc status in patients with major thalassemia in Sistan and Baluchistan province, southeastern Iran.Patients and Methods:The study was performed in Ali Asghar Hospital, a specialized governmental hospital located in Zahedan, Iran. In this cross-sectional study, 369 patients with a history of major thalassemia for more than 5 years entered the study using convenience sampling method. Thirty-six subjects were excluded from the study based on our exclusion criteria. Zinc level was measured in all patients after 12 hours fasting using atomic absorption spectrometry method in 2012.Results:Of 369 cases, 333 patients were eligible and evaluated. The mean age was 15.63 ± 7.4 years. One hundred ninety two cases were male and others were female (141 cases). About 27% (90) of the cases were 5-10 years-old, 24% (80) were 10-15 years-old and 49% were older than 15 years old. Iron chelator in 65.46% was Desferrioxamine, in 28.2% was Deferasirox and in 19.5% was combination of Desferrioxamine and Deferiprone. All cases had zinc deficiency, and 98.5% had severe zinc deficiency. Others (1.5%) had mild deficiency.Conclusions:Our study on 333 patients with major thalassemia documented severe zinc deficiency in all cases. We had no cases with normal or increased zinc levels. It was different with other reports in the world.

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Effect of different dietary zinc levels on hepatic antioxidant and micronutrients indices under oxidative stress conditions

Cited by 29 publications

References 52 publications

Psychological stress induced zinc accumulation and up-regulation of ZIP14 and metallothionein in rat liver

Psychological stress induced zinc accumulation and up-regulation of ZIP14 and metallothionein in rat liver

Trace elements in glucometabolic disorders: an update

The Prevalence of Zinc Deficiency in Patients With Thalassemia in South East of Iran, Sistan and Baluchistan Province

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