Effect of differing amounts of zinc oxide supplementation on the antioxidant status and zinc metabolism in newborn dairy calves

Wei, Jingya; Ma, Fengtao; Hao, Liyuan; Shan, Qiang; Sun, Pu

doi:10.1016/j.livsci.2019.103819

Cited by 16 publications

(16 citation statements)

References 38 publications

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“…Although supplementation with zinc in the form of Zn-Met increased serum and hepatic zinc concentrations, it did not affect iron or copper concentrations in the dairy calves, which implies that dietary zinc supplementation does not interfere with the absorption of iron or copper under the conditions in which the present study was conducted. This may be attributable to the relatively low dose of zinc provided by the amount of Zn-Met or ZnO added to the diet, as shown in our previous study [6]. Similar results were also obtained by Jia et al [25], who found no effect of zinc supplementation on the serum concentrations of copper and iron in Cashmere goats.…”

Section: Discussionsupporting

confidence: 90%

“…The groups were as follows: (1) control group (CON, no supplemental ZnO or Zn-Met provided); (2) Zn-Met group (consuming 455 mg Zn-Met per day, equivalent to 80 mg zinc); and (3) ZnO group (consuming 103 mg ZnO per day, equivalent to 80 mg zinc). The supplemented zinc level was based on previous publications [6,8,9]. The trial lasted for 14 days.…”

Section: Animals Diets and Experimental Designmentioning

confidence: 99%

“…On days 4-14, a total of 8 L milk was fed daily using a bucket. Zn-Met or ZnO were mixed with 200 mL colostrum or milk and provided to the calves on days 1-14, as described in our previous study [6]. Then, more colostrum or milk were fed to the calves.…”

Section: Animals Diets and Experimental Designmentioning

confidence: 99%

“…We previously evaluated the optimal dose of zinc for neonatal calves and showed that 80 mg zinc, in the form of ZnO, has the potential to alleviate newborn calf diarrhea [6]. In a subsequent study, we compared the effects of the same dose of zinc, provided in organic or inorganic form, on the growth and incidence of diarrhea in dairy calves, and showed that a low dose of zinc methionine (Zn-Met) or ZnO can ameliorate diarrhea in young calves, which is not the result of effects on rectal microbial composition or diversity [7].…”

Section: Introductionmentioning

confidence: 99%

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Effect of the Source of Zinc on the Tissue Accumulation of Zinc and Jejunal Mucosal Zinc Transporter Expression in Holstein Dairy Calves

et al. 2020

Animals

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Zinc is considered to be an anti-diarrheal agent, and it may therefore reduce the incidence of diarrhea in young calves. In the present study, we aimed to compare the effect of zinc source on growth performance, the incidence of diarrhea, tissue zinc accumulation, the expression of zinc transporters, and the serum concentrations of zinc-dependent proteins in neonatal Holstein dairy calves. Eighteen male newborn Holstein dairy calves were fed milk and starter diet supplemented with or without 80 mg zinc/d in the form of Zn-Met or ZnO for 14 days, and were then euthanized. Zn-Met supplementation improved average daily gain and feed efficiency, and reduced the incidence of diarrhea, compared with control calves (p < 0.05). It also increased the serum and hepatic zinc concentrations and the mRNA expression of the ZIP4 transporter in the jejunal mucosa of the calves (p < 0.05). In addition, the serum alkaline phosphatase activity and metallothionein concentration were higher in Zn-Met-treated calves than in control calves (p < 0.05). ZnO supplementation had similar effects, but these did not reach significance. Thus, Zn-Met supplementation is an effective means of increasing tissue zinc accumulation and jejunal zinc absorption, and can be used as an anti-diarrheal strategy in neonatal calves.

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Section: Discussionsupporting

confidence: 90%

Section: Animals Diets and Experimental Designmentioning

confidence: 99%

Section: Animals Diets and Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of the Source of Zinc on the Tissue Accumulation of Zinc and Jejunal Mucosal Zinc Transporter Expression in Holstein Dairy Calves

et al. 2020

Animals

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“…The control calves were fed starter that was not supplemented with ZnO or Zn-Met, and the calves in the treatment groups received either 104 mg of ZnO (analytical-grade; Sigma-Aldrich, Taufkirchen, Germany; yielding 80 mg/d zinc) or 457 mg of Zn-Met (feed grade; http: / / www .finechem -china .com/ ; yielding 80 mg/d zinc) daily. This level of zinc supplementation was determined on the basis of previous publications (Glover et al, 2013;Feldmann et al, 2019;Wei et al, 2019). The appropriate amount of ZnO or Zn-Met was mixed with 200 mL of milk, and administered to each calf using an oral dispenser, after which more milk was fed.…”

Section: Experimental Design and Sample Collectionmentioning

confidence: 99%

Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn dairy calves

Chang

Wei

Hao

et al. 2020

Journal of Dairy Science

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Neonatal diarrhea in dairy calves causes huge economic and productivity losses in the dairy industry. Zinc is an effective anti-diarrheal agent, but high doses may pose a threat to the environment. Therefore, we aimed to evaluate the effects of low-dose zinc supplementation on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn Holstein dairy calves. Thirty newborn calves were allocated to either a control group (without extra zinc supplementation), or groups supplemented with either 104 mg of zinc oxide (ZnO, equivalent to 80 mg of zinc/d) or 457 mg of zinc methionine (Zn-Met, equivalent to 80 mg of zinc/d) and studied them for 14 d. The rectal contents were sampled on d 1, 3, 7, and 14, and blood samples were collected at the end of the study. Supplementation with ZnO reduced the incidence of diarrhea during the first 3 d of life, and increased serum IgG and IgM concentrations. The Zn-Met supplementation increased growth performance and reduced the incidence of diarrhea during the first 14 d after birth. The results of fecal microbiota analysis showed that Firmicutes and Proteobacteria were the predominant phyla, and Escherichia and Bacteroides were the dominant genera in the recta of the calves. As the calves grew older, rectal microbial diversity and composition significantly evolved. In addition, dietary supplementation with ZnO reduced the relative abundance of Proteobacteria in 1-d-old calves, and increased that of Bacteroidetes, Lactobacillus, and Faecalibacterium in 7-d-old calves, compared with the control group. Supplementation with Zn-Met increased the relative abundance of the phylum Actinobacteria and the genera Faecalibacterium and Collinsella on d 7, and that of the genus Ruminococcus after 2 wk, compared with the control group. Thus, the rectal microbial composition was not affected by zinc supplementation but significantly evolved during the calves' early life.Zinc supplementation reduced the incidence of diarrhea in young calves. In view of their differing effects, we recommend ZnO supplementation for dairy calves during their first 3 d of life and Zn-Met supplementation for the subsequent period. These findings suggest that zinc supplementation may be an alternative to antibacterial agents for the treatment of newborn calf diarrhea.

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The Dietary Supplementation of Copper and Zinc Nanoparticles Improves Health Condition of Young Dairy Calves by Reducing the Incidence of Diarrhoea and Boosting Immune Function and Antioxidant Activity

Pandey

Kumar

et al. 2022

Biol Trace Elem Res

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Effect of differing amounts of zinc oxide supplementation on the antioxidant status and zinc metabolism in newborn dairy calves

Cited by 16 publications

References 38 publications

Effect of the Source of Zinc on the Tissue Accumulation of Zinc and Jejunal Mucosal Zinc Transporter Expression in Holstein Dairy Calves

Effect of the Source of Zinc on the Tissue Accumulation of Zinc and Jejunal Mucosal Zinc Transporter Expression in Holstein Dairy Calves

Effects of different types of zinc supplement on the growth, incidence of diarrhea, immune function, and rectal microbiota of newborn dairy calves

The Dietary Supplementation of Copper and Zinc Nanoparticles Improves Health Condition of Young Dairy Calves by Reducing the Incidence of Diarrhoea and Boosting Immune Function and Antioxidant Activity

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