Effect of Dilatation of the Cerebral Ventricles After the Administration of Nitroxynil in Swiss Albine Mice During Organogenesis

Abstract

Nitroxynil 34% is an anthelmintic of the family of phenolic substitutes that is used for treatment and control of Fasciola hepatica, but is very effective in controlling haemoncosis in sheep. The objective of this study was to evaluate the effects of nitroxynil administered to female Swiss albine mice during the period of organogenesis. A total of 40 mice (30 females and 10 males), randomized into three mated female groups were used: Gc, control animals that were not exposed to nitroxynil; G10, animals that received nitroxynil at the dosage of 10 mg / kg; and G40, where 40 mg / kg of nitroxynil was administered. All animals received the pre-determined dosage of nitroxynil 34%, via subcutaneous, on the 6th day of pregnancy, and were euthanized on day 21 of gestation. The fetuses and uterus were evaluated for gross abnormalities. The results have demonstrated that the administration of nitroxynil had no influence on the reproductive indices, post-implantation losses, and the number of implantation sites. However, histopathological evaluation of fetal brain revealed an increased in the occurrence of ventricular dilatation. These results suggest that the subcutaneous administration of nitroxynil 34% at the doses of 10 and 40mg/kg, in a single application, on the 6th day of pregnancy in female mice, resulted in alterations on the brain of mice and on the birth weight of the fetus. Key Words: anthelminthic drug; embryonic toxicity; phenolic substitutes; laboratory animals Effect of dilatation of the cerebral ventricles after the administration of nitroxynil in Swiss albine mice during organogenesis EFEITO DE DILATAÇÃO DOS VENTRÍCULOS CEREBRAIS APÓS A ADMINISTRAÇÃO DE NITROXINIL EM CAMUNDONGOS SWISS

Effects of triclabendazole and nitroxynil on EPG, hematological parameters and body weight against fascioliasis in goats at government goat development farm, Sylhet, Bangladesh

“…However it could be concluded that, nitroxynil is a potent anthelmintic from the family of substituted phenols that is utilized in ruminants for the control of trematodes, particularly for Fasciola hepatica [23].…”