Effect of Disinfectants Based on Potassium Persulfate, Hydrogen Peroxide, Glutaraldehyde and Quaternary Ammonium Compounds on the Genetic Material of the Pathogen Bacteria Specific to Meat Processing Industry

Afonyushkin, V. N.; Tabanyukhov, K. A.; Cherepushkina, V. S.; Khomenko, Yu. S.; Tatarchuk, O. P.

doi:10.21323/2114-441x-2016-1-54-61

Cited by 4 publications

(1 citation statement)

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“…Clinical observations showed the effectiveness of Ecocid, Triviron, Argovit, and lauric acid monoglyceride (C12) against viral mal-absorption in poultry farms (flavivirus, astroviral etiology). Ecocid shows high antibacterial and virucidal activity combined with low toxicity and stability in a living organism, making it a promising alternative as a topical virucidal agent [ 12 ] and a disinfectant that prevents the horizontal transfer of antibiotic resistance genes [ 13 ]. Triviron virucidal formulation began to be used in veterinary medicine relatively recently [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route

Нефедова

Koptev

Bobikova

et al. 2021

Veterinary Sciences

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Infectious bronchitis (IB) of chickens is a highly contagious disease characterized by damage of the respiratory system and reproductive organs in young animals caused by a virus of the genus Gamma coronavirus. The condition of the respiratory system caused by the IB virus in chickens has many similarities with the pathology of the respiratory system caused by SARS-CoV-2 in humans. The effectiveness of virucidal drugs (Argovit, Triviron, Ecocid, and lauric acid monoglyceride) was tested on chickens inoculated with a tenfold dose of a vaccine strain based on the attenuated virus H120 against IB of chickens. On the 6th day after inoculation, inflammatory changes in the intestines, lungs, and thymus were observed in the control group. The experimental groups were characterized by less pronounced inflammatory reactions and a lower proportion of thymus and lung probes containing genomic IB virus RNA. Since the virucidal activity of four orally administrated formulations was possible only in the intestine, the experimental data indirectly confirmed the hypothesis of the possibility of the predominant accumulation of coronaviruses in the intestine and subsequent lung damage due to the hematogenous redistribution of viral particles and IBV antigens. It was suggested that other coronaviruses including SARS-CoV-2 can implement a similar mechanism.

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Section: Introductionmentioning

confidence: 99%

The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route

Нефедова

Koptev

Bobikova

et al. 2021

Veterinary Sciences

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Using aerosols to decontaminate surfaces from nucleic acids

Kuzin

Shcherbakova

Dyatlov

2023

Microbiology Independent Research Journal (MIR Journal)

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Cross-contamination that leads to false positive results is a serious problem for laboratories using the PCR method. There are many ways to solve this problem, but none of them could be considered universal. Treatment with aerosols is the preferable method for decontamination of large areas of complex surfaces. The goal of this study was to determine effective aerosol compositions and regimens for the decontamination of nucleic acids on laboratory surfaces. The decontaminating activity of compounds that release active chlorine and active oxygen was studied using model surfaces contaminated with nucleic acids and bacteria. Effective modes of decontamination with aerosols were established by analysis of obtained experimental data. Differences between decontamination of nucleic acids and bacterial disinfection of the laboratory surfaces are shown.

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Деконтаминация Поверхностей От Нуклеиновых Кислот Аэрозолями Дезинфицирующих Средств

Кузин¹,

Shcherbakova²,

Дятлов³

2023

Microbiology Independent Research Journal (MIR Journal)

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Важной проблемой при работе в ПЦР-лаборатории является возникновение перекрестного загрязнения, которое приводит к появлению ложноположительных результатов. Существует множество способов решения данной проблемы, однако ни один из них не является универсальным. Для деконтаминации сложных поверхностей большой площади предпочтительнее использовать аэрозольный метод обработки. Цель данного исследования заключалась в определении эффективных режимов применения дезинфицирующих средств для деконтаминации от нуклеиновых кислот аэрозольным методом. Анализ деконтаминирующей активности хлорактивных и кислородактивных соединений проводили, моделируя контаминацию поверхностей нуклеиновыми кислотами и бактериями. В процессе работы установлены эффективные режимы проведения аэрозольной деконтаминации. Показаны различия при удалении нуклеиновых кислот и бактериального загрязнения с лабораторных поверхностей.

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Effect of Disinfectants Based on Potassium Persulfate, Hydrogen Peroxide, Glutaraldehyde and Quaternary Ammonium Compounds on the Genetic Material of the Pathogen Bacteria Specific to Meat Processing Industry

Cited by 4 publications

References 0 publications

The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route

The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route

Using aerosols to decontaminate surfaces from nucleic acids

Деконтаминация Поверхностей От Нуклеиновых Кислот Аэрозолями Дезинфицирующих Средств

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