Effect of Dopamine Blockers on Cerebral Ischemia-Induced Hyperactivity in Gerbils

Araki, Hiroaki; Hino, Noriko; Karasawa, Yasuko; Kawasaki, Hiromu; Gomita, Yutaka

doi:10.1016/s0031-9384(98)00293-5

Cited by 14 publications

(8 citation statements)

References 23 publications

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“…Our findings indicated dose-related effects of resveratrol on behavior in ischemic animals and altered performance of sham animals treated with 10 mg/kg of resveratrol in discrete behavioral tests, the latter suggesting long-lasting intrinsic actions of resveratrol to regulate locomotion and memory. These observations further suggest that increased locomotion observed in 10 mg/kg-treated ischemic rats is linked to intrinsic effects of higher resveratrol dosages on neurochemical pathways mediating this response (Poignet et al, 1989;Araki et al, 1999). Our study further indicated that locomotor activity was enhanced in resveratrol-treated sham rats at the same time interval.…”

Section: Retention (Mean Errors)supporting

confidence: 73%

Repeated resveratrol administration confers lasting protection against neuronal damage but induces dose-related alterations of behavioral impairments after global ischemia

Girbovan

Morin²,

Plamondon³

2012

Behavioural Pharmacology

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Resveratrol, a naturally occurring polyphenol, has been shown to protect the heart and brain against ischemic injury. The current study investigated the effects of administration with either a 1 or 10-mg/kg dose of resveratrol on CA1 neuronal injury and behavioral/cognitive impairments after 10-min global ischemia in rats. The open-field, eight-arm radial maze and object recognition tests served to evaluate effects of resveratrol treatment on ischemia-induced locomotor activity, and spatial and recognition memory impairments, respectively. CA1 and CA3 neuronal injury was assessed upon completion of behavioral testing, 85 days postischemia. A separate series of groups served to assess neuronal injury at 7 days postischemia. Global ischemia (10 min) led to approximately 50% CA1 cell injury, which was prevented at both short (7 days) and long (85 days) postischemic intervals by resveratrol treatment. Importantly, despite comparable neuronal protection, the two resveratrol doses showed distinct behavioral effects. Thus, the 10-mg/kg resveratrol dose led to an enhanced locomotor activity in the open-field 4-days postischemia and an impaired spatial memory in the delayed nonmatching to sample and delayed matching to sample radial-maze tasks initiated on day 13 postischemia. These findings suggest independent actions of resveratrol on distinct physiological systems mediating cellular survival and functional recovery and dose-related actions of the polyphenol on behavioral and memory processes.

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Section: Retention (Mean Errors)supporting

confidence: 73%

Repeated resveratrol administration confers lasting protection against neuronal damage but induces dose-related alterations of behavioral impairments after global ischemia

Girbovan

Morin²,

Plamondon³

2012

Behavioural Pharmacology

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“…Microscopic lesions were found in striatum, the damage being mainly located in its dorsolateral part and affecting the medium-sized spiny projection neurons, which may underlie the hyperactivity after global ischemia (Chesselet, Gonzales et al, 1990;Janac, Radenovic et al, 2006). Administration of the D2 receptor antagonists haloperidol, sulpiride, and eticlopride decreased ischemia-induced hyperactivity in Mongolian gerbils, suggesting that the global ischemia – mediated hyperactivity is related to abnormalities in dopaminergic functions (Araki, Hino et al, 1999). In contrast to short term global ischemia, focal ischemia decreases locomotor activity as seen in the present and in previous studies (Hattori, Lee et al, 2000;Tomac, Agulnick et al, 2002;Ji, Chai et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Correlation of locomotor activity and brain infarction in rats with transient focal ischemia

Shen

Wang

2010

Journal of Neuroscience Methods

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Occlusion of middle cerebral artery (MCAo) is commonly used to generate stroke in experimental animals. Different behavioral assays have been used to evaluate the severity of lesions or recovery after treatment in this model. In this study, we examined the correlation between the size of infarction and locomotor activity after transient MCAo in adult Sprague Dawley rats. The right middle cerebral artery was occluded for 30 to 90 -min by ligation with a 10-O suture. At 2 days after MCAo, animals were individually placed in a 3-D infra-red activity chamber for 1 hour to measure their horizontal, vertical, stereotypic and rotational activity. Body asymmetry was examined using an elevated body swing test. Volume of infarction was measured by triphenyltetrazolium chloride staining. We found that there is a significant correlation between the volume of infarction and vertical movement, such as vertical activity, vertical movement number and vertical movement time. There is also a significant correlation between the infarction volume and body asymmetry. In conclusion, our data suggest that vertical locomotor activity and body asymmetry are useful behavioral indices to estimate the size of lesioning in rodents after MCAo. KeywordsStroke; Middle cerebral artery occlusion; behavior Occlusion of the middle cerebral artery (MCAo) is commonly used to generate focal ischemia in experimental animals. Depending on the loci of occlusion, the methods used for MCAo in rodents can be characterized into two groups: proximal and distal MCAo. Proximal MCAo can be introduced by inserting a monofilament through the carotid artery to reach the junction of MCA, thus blocking the blood flow from the common carotids and the circle of Willis (Chang, Niu et al., 2000). Distal MCAo is often done by occlusion of the MCA at the distal branch, i.e. before the first branch above zygomatic arch, after craniotomy. Distal MCAo can be achieved through laser or cauterization, which generates permanent occlusion, or by ligation with suture for 45 to 90 min, which produces transient ischemia. Depending on the model of MCAo used and the duration of ischemia, animals can develop cerebral infarction in selective ischemic regions. Corresponding author: Hui Shen MD, Neural Protection and Regeneration Section, National Institute on Drug Abuse, IPR, 251 Bayview Blvd., Baltimore, MD 21224, hshen@intra.nida.nih.gov. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptSeveral reports have indicated that locomotor activity is supp...

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“…Katsuta et al [30] established an association between hippocampal CA1 cell damage and hyperlocomotion following global cerebral ischemia in gerbils. Furthermore, this postischemic hyperlocomotion appears to be related to abnormalities in dopamine function [31–33].…”

Section: Discussionmentioning

confidence: 99%

Does rat global transient cerebral ischemia serve as an appropriate model to study emotional disturbances?

Bantsiele

Bentué-Ferrer

Amiot

et al. 2004

Fundamemntal Clinical Pharma

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We used two validated psychopharmacological methods, the forced swimming test (FST 20 min and 5 min) and the elevated plus-maze (EPM), to quantify depression-like and anxiety-like behavior induced by transient global cerebral ischemia in the rat. We also validated use of these methods for the study of antidepressant (imipramine) and anti-anxiety drugs (diazepam). Twelve days after surgery to provoke transient global ischemia, spontaneous motor activity was 40% higher in ischemic rats than in sham-operated controls. Duration of immobility during the FST 20 min and 5 min was 28 and 30% shorter, respectively, than in controls. Treatment with imipramine (3 x 30 mg/kg i.p.) induced a significantly shorter duration of immobility during the FST 5 min, but with no difference between ischemia and control rats. The EPM demonstrated that ischemia did not induce any change in the six behavior parameters measured. Diazepam (1.5 mg/kg i.p.) induced significant anxiolytic effects which were similar in ischemic and sham-operated animals. Both tests failed to demonstrate perturbed performance but conversely, these findings did disclose the sensitivity of ischemia-exposed rats to the action of imipramine and diazepam, demonstrating the usefulness of these tests as psychopharmocological tools for evaluating the effect of psychotropics in the ischemic rat.

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Effect of Dopamine Blockers on Cerebral Ischemia-Induced Hyperactivity in Gerbils

Cited by 14 publications

References 23 publications

Repeated resveratrol administration confers lasting protection against neuronal damage but induces dose-related alterations of behavioral impairments after global ischemia

Repeated resveratrol administration confers lasting protection against neuronal damage but induces dose-related alterations of behavioral impairments after global ischemia

Correlation of locomotor activity and brain infarction in rats with transient focal ischemia

Does rat global transient cerebral ischemia serve as an appropriate model to study emotional disturbances?

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