Effect of dopamine infusion on thyroid hormone tests and prolactin levels in very low birth weight infants

Ekmen, Sadrettin; Değirmencioğlu, Halil; Uraş, Nurdan; Öncel, Mehmet Yekta; Sarı, Fatma Nur; Canpolat, Fuat Emre; Oguz, SS; Dilmen, Uğur

doi:10.3109/14767058.2014.937696

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Viewing connection from claiming serum prolactin level What's more organization from claiming Inotropes Around ailing neonate, we discovered that there were no Factual essentialness distinction the middle of serum prolactin level What's more organization for Inotropes Around ailing neonates. Over concur with us, Ekmen et al , [29] accounted that, serum PRL levels were essentially higher clinched alongside bunch 1 over in Assemblies 2 and 3 (p50. 05), However there might have been no noteworthy distinction between gatherings 2 Also 3 (p40.…”

Section: Discussionsupporting

confidence: 83%

Estimation of Prolactin Level in Healthy and Respiratory Distressed Preterm Baby and Estimation of Risk factors

Dabour

Esmail

Assar

et al. 2020

Benha Journal of Applied Sciences

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Past investigations bring demonstrated the could be allowed part of prolactin in the improvement of RDS, Yet they didn't think about those maternal states which could impact the watched quality. We pointed with think about serum prolactin level Around sound preterm neonates Also preterm neonate for respiratory misery syndrome. Methods: those examine included 80 neonates (51 guys and 29 females). Those 1st one assembly (diseased): included 40 preterm babies for respiratory misery syndrome. Those second assembly (control): incorporated 40 solid preterm neonates. At baby subjected with research apgar score at 1 and 5 minutes. Serum Prolactin level might have been evaluated utilizing IRMA unit supplied Eventually Tom's perusing izotop Results: we watched helter skelter measurable noteworthy diminish from claiming serum prolactin level (ng/ml) Around preterm babies with RDS contrasted with the control aggregation for (P. Worth <0. 001). Prolactin need been distinguished Concerning illustration a could be allowed trigger for surfactant amalgamation Also hence it may bring a part over lung improvemen. Our comes about uncovered helter skelter statistically huge certain connection for serum prolactin level for gestational agdistis P-value< 0. 001** which demonstrate that prolactin expanded with expanding gestational period. Conclusion:. We presume starting with our consider that serum prolactin increments alongside more seasoned gestational agdistis What's more is emphatically corresponded with seriousness from claiming respiratory trouble. The more level serum prolactin level those that's only the tip of the iceberg extreme might have been the RDS condition.

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Section: Discussionsupporting

confidence: 83%

Estimation of Prolactin Level in Healthy and Respiratory Distressed Preterm Baby and Estimation of Risk factors

Dabour

Esmail

Assar

et al. 2020

Benha Journal of Applied Sciences

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“…Dopamine has been shown to suppress pituitary function in preterm infants, resulting in decreased levels of thyroidstimulating hormone, thyroxin and prolactin, but extensive description of dopamine related endocrine effects is out of scope of the current literature review [14,[32][33][34][35].…”

Section: Dosingmentioning

confidence: 99%

Cardiovascular Drug Therapy for Human Newborn: Review of Pharmacodynamic Data

Ergenekon

Rojas-Anaya

Bravo

et al. 2018

CPD

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Background: Circulatory failure in preterm and term newborn infants is commonly treated with inotropes or vasoactive medications. In this structured literature review the available data on pharmacodynamic effects of the inotropes adrenaline, dobutamine, dopamine, levosimendan, milrinone, noradrenaline, and the vasoactive drugs vasopressin and hydrocortisone are presented. Methods: Structured searches were conducted to identify relevant articles according to pre-defined inclusion criteria which were human clinical trials published after 2000.Results: Out of 101 identified eligible studies only 22 studies met the criteria for evidence based practice guidelines level I to IV. The most prevalent pharmacodynamic effects were increase in blood pressure and/or heart rate, which were also the most frequently studied circulatory parameters. Conclusion: This review demonstrates the need for further systematic studies on all reviewed drugs with incorporation of novel noninvasive biomarkers in this vulnerable patient group, for more timely and appropriate treatment for clinical efficacy.

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“…Bowden et al described the inhibition of TSH release induced by glucocorticoids, somatostatin, and dopamine (46). However, Ekmen et al suggests that TSH, T3 and T4 levels are not disturbed during dopamine infusions (47). Bearing in mind that dopamine is known to suppress thyrotropin release, there is an urgent need to conduct more trials concerning its impact on infant's TH.…”

Section: Pre-and Postnatal Medicationsmentioning

confidence: 99%

Congenital Hypothyroidism in Preterm Newborns – The Challenges of Diagnostics and Treatment: A Review

2022

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Preterm newborns are forced to adapt to harsh extrauterine conditions and endure numerous adversities despite their incomplete growth and maturity. The inadequate thyroid hormones secretion as well as the impaired regulation of hypothalamus-pituitary-thyroid axis may lead to hypothyroxinemia. Two first weeks after birth are pivotal for brain neurons development, synaptogenesis and gliogenesis. The decreased level of thyroxine regardless of cause may lead to delayed mental development. Congenital hypothyroidism (CH) is a disorder highly prevalent in premature neonates and it originates from maternal factors, perinatal and labor complications, genetic abnormalities, thyroid malformations as well as side effects of medications and therapeutic actions. Because of that, the prevention is not fully attainable. CH manifests clinically in a few distinctive forms: primary, permanent or transient, and secondary. Their etiologies and implications bear little resemblance. Therefore, the exact diagnosis and differentiation between the subtypes of CH are crucial in order to plan an effective treatment. Hypothyroxinemia of prematurity indicates dynamic changes in thyroid hormone levels dependent on neonatal postmenstrual age, which directly affects patient’s maintenance and wellbeing. The basis of a successful treatment relies on an early and accurate diagnosis. Neonatal screening is a recommended method of detecting CH in preterm newborns. The preferred approach involves testing serum TSH and fT4 concentrations and assessing their levels according to the cut-off values. The possible benefits also include the evaluation of CH subtype. Nevertheless, the reference range of thyroid hormones varies all around the world and impedes the introduction of universal testing recommendations. Unification of the methodology in neonatal screening would be advantageous for prevention and management of CH. Current guidelines recommend levothyroxine treatment of CH in preterm infants only when the diagnose is confirmed. Moreover, they underline the importance of the re-evaluation among preterm born infants due to the frequency of transient forms of hypothyroidism. However, results from multiple clinical trials are mixed and depend on the newborn’s gestational age at birth. Some benefits of treatment are seen especially in the preterm infants born <29 weeks’ gestation. The discrepancies among trials and guidelines create an urgent need to conduct more large sample size studies that could provide further analyses and consensus. This review summarizes the current state of knowledge on congenital hypothyroidism in preterm infants. We discuss screening and treatment options and demonstrate present challenges and controversies.

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Effect of dopamine infusion on thyroid hormone tests and prolactin levels in very low birth weight infants

Abstract: The release of TSH, FT3, FT4 and PRL were not inhibited and prophylactic thyroid hormone treatment was not required in VLBW infants receiving dopamine infusions.

Cited by 5 publications

References 19 publications

Estimation of Prolactin Level in Healthy and Respiratory Distressed Preterm Baby and Estimation of Risk factors

Estimation of Prolactin Level in Healthy and Respiratory Distressed Preterm Baby and Estimation of Risk factors

Cardiovascular Drug Therapy for Human Newborn: Review of Pharmacodynamic Data

Congenital Hypothyroidism in Preterm Newborns – The Challenges of Diagnostics and Treatment: A Review

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