Effect of dopamine on intracellular sodium: A common pathway for pharmacological mechanism of action in bipolar illness

Roberts, R. Jeannie; Repass, Richard; El‐Mallakh, Rif S.

doi:10.3109/15622970902718774

Cited by 17 publications

(9 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, excess dietary sodium has been linked to elevations in blood pressure (BP) (18). Previous studies have shown that high levels of tissue sodium are associated with a variety of conditions ranging from elevated BP to brain tumors, stroke, and bipolar disorder (8,9,28,36,42,47,51,55). Recent research has highlighted the importance of cerebral spinal fluid (CSF) sodium in regulating sympathetic activity in experimental rat (26,37,39) and mouse models (40,53).…”

Section: Introductionmentioning

confidence: 99%

Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer’s disease

Souza

Trebak

Kumar

et al. 2020

Physiological Genomics

View full text Add to dashboard Cite

High salt (sodium) intake leads to the development of hypertension despite the fact that plasma sodium concentration ([Na+]) is usually normal in hypertensive human patients. Increased cerebrospinal fluid (CSF) sodium contributes to elevated sympathetic activity and high blood pressure (BP) in rodent models of hypertension. However, whether there is an increased accumulation of sodium in the CSF of humans with chronic hypertension is not well defined. Here, we investigated CSF [Na+] from hypertensive and normotensive human subjects with family histories of Alzheimer’s disease in samples collected in a clinical trial, as spinal tap is not a routine clinical procedure for hypertensive patients. The [Na+] and osmolality in plasma and CSF were measured by flame photometry. Daytime ambulatory BP was monitored while individuals were awake. Participants were deidentified and data were analyzed in conjunction with a retrospective analysis of patient history and diagnosis. We found that CSF [Na+] was significantly higher in participants with high BP compared with normotensive participants; there was no difference in plasma [Na+], or plasma and CSF osmolality between groups. Subsequent multiple linear regression analyses controlling for age, sex, race, and body mass index revealed a significant positive correlation between CSF [Na+] and BP but showed no correlation between plasma [Na+] and BP. In sum, CSF [Na+] was higher in chronic hypertensive individuals and may play a key role in the pathogenesis of human hypertension. Collectively, our findings provide evidence for the clinical significance of CSF [Na+] in chronic hypertension in humans.

show abstract

Section: Introductionmentioning

confidence: 99%

Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer’s disease

Souza

Trebak

Kumar

et al. 2020

Physiological Genomics

View full text Add to dashboard Cite

show abstract

“…We believe that the different by an activity-dependent inhibition of Na ϩ channels (El-Mallakh and Huff 2001). Mood stabilizing antipsychotics may also have an effect of reducing intracellular sodium (Roberts et al 2010).…”

Section: Discussionmentioning

confidence: 98%

Effect of ionic stress on apoptosis and the expression of TRPM2 in human olfactory neuroepithelial-derived progenitors

Gao

Lei

et al. 2010

The World Journal of Biological Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Enzymatic activity is highly dependent on magnesium and lithium directly inhibits GSK-3β by acting as a competitive inhibitor of magnesium; magnesium being a cofactor for ATP in GSK-3β activation (Fig. 4) (Ryves and Harwood 2001). Thus, GSK-3β inhibition by lithium protects/rescues the brain from apoptotic cell death; and neural dysfunction results from the failure to completely inhibit GSK-3β (Grimes and Jope 2001a).…”

Section: Lithiummentioning

confidence: 99%

“…An increase in intracellular sodium concentration mediated by dopaminergic pathways is a characteristic of bipolar disorder and lithium normalizes this increase (Roberts et al 2009). Studies show that combined estrogen and lithium alter serotonin and dopamine metabolites.…”

Section: Estrogen and Lithium; Or Lithium As A Selective Estrogen-mementioning

confidence: 99%

Lithium: a potential estrogen signaling modulator

Valdés¹,

Weeks²

2009

J Appl Biomed

View full text Add to dashboard Cite

Estrogen replacement therapy (ERT) engenders much debate since several studies contradict its efficacy as a palliative therapy for cognitive decline and neurodegenerative diseases. Signaling transduction pathways alter brain cell activity, survival, and morphology by facilitating transcription factor activation and protein production. The steroidal hormone estrogen and the anti-depressant drug lithium can interact also through these signaling transduction pathways resulting in transcription factor activation. The transcription factor cAMP response element binding protein (CREB) is affected by both estrogen and lithium, and CREB regulates genes involved in learning, memory and neuronal survival. CREB is activated upon phosphorylation at serine 133 by protein kinases and, estrogen and its receptors (ER) facilitate this phosphorylation. Glycogen synthase kinase-3beta (GSK-3β) attenuates CREB's transcriptional properties via subsequent phosphorylation of its serine 129, and lithium is known as a negative regulator of GSK-3β, thus facilitating CREB response element binding. Interestingly, ERα function and DNA-binding properties are facilitated by GSK-3β. In this review we include protein modeling depicting the interaction of CREB/GSK-3β and ERα/GSK-3β using I-TASSER and PatchDock web servers. Understanding the molecular pathways of estrogen will assist in identifying a palliative therapy for menopause-related dementia, and lithium may serve this purpose by acting as a selective estrogen-mediated signaling modulator.

show abstract

Effect of dopamine on intracellular sodium: A common pathway for pharmacological mechanism of action in bipolar illness

Cited by 17 publications

References 69 publications

Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer’s disease

Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer’s disease

Effect of ionic stress on apoptosis and the expression of TRPM2 in human olfactory neuroepithelial-derived progenitors

Lithium: a potential estrogen signaling modulator

Contact Info

Product

Resources

About