Effect of drug incorporation and polymer properties on the characteristics of electrospun nanofibers for drug delivery

Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions

“…Reprinted with permission from ref Ramos et al (2021) a plasticizer by increasing the amount of free space in the system and by preventing polymer chain overlap and entanglement. This phenomenon has the potential to drastically lower the solution's viscosity, which will eventually lead to the creation of thinner nanofibers and a thinner jet (Gelb et al, 2022).…”

Electrospun-Fibrous-Architecture-Mediated Non-Viral Gene Therapy Drug Delivery in Regenerative Medicine

“…Since the architectural and morphological characteristics of electrospun structures can be greatly modulated and controlled during the electrospinning process by adapting certain parameters (e.g., the applied electric voltage, the solution flow rate, collecting the distance between the needle tip and the target, the geometry and rotation speed of the collector or the needle movement speed), solution properties (e.g., polymeric solution viscosity, polymer concentration, solution surface tension, surface charge, electrical conductivity and the dielectric constant) or environmental parameters (e.g., temperature, humidity) [30,68], this technique has attracted worldwide research interest, being used in different fields of biomedicine and biotechnology. Owing to their multifarious morphological designs (e.g., hollow, core-shell, porous, beaded and ribbon-like structures), versatility in the incorporation of diverse bioactives (e.g., drug molecules, genes or proteins) [69], large specific surface area, high interconnected porosity and permeability along with their ability to efficiently deliver the loaded cargoes in a high spatial and temporal regulated manner, these structures are ubiquitous in tissue engineering [26,70,71], controlled drug delivery [72][73][74] and gene therapy [75][76][77].…”

Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds

“…Moreover, they can be functionalized to modulate the drug release ( Zong et al, 2022 ). They can provide sustained-release profile that results in a reduction in the frequency of administration and thus enhance patient compliance ( Gelb et al, 2022 ). Attractive physical properties of nanofibers such as the high surface-area-to-volume ratio, high porosity, flexibility, high drug-loading capacity, biocompatibility, biodegradability and increasing the contact time of drug with target tissues make them a unique candidate for drug delivery applications, diagnosis and treatment of different diseases, particularly for chronic ocular diseases that require frequent drug administration.…”