Effect of Early Correction of Hyponatremia on Neurological Outcome in Traumatic Brain Injury Patients

Ahmad, Khalil; Alrais, Zeyad Faoor; Elkholy, Hesham Mohamed; Elkhouly, Adel Elsaid; Beniamein, Maged Mohsen; Hadi, Ammar Abdel; Majeed, Sohail; Shoaib, Ahmad

doi:10.21767/2471-8505.100064

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Limited functional recovery after TBI is attributed to progressive neuronal damage following secondary injury-related inflammation [151,152]. Based on their previous work, one group of researchers [153] coupled dexamethasone (DX) with hyaluronic acid to obtain HA-DXM, which reduced neuroinflammation when loaded with degradable hydrogel poly (ethylene glycol-bis-(acryl-oxy-acetate)) (PEG-bis-AA). Furthermore, it improved neuronal survival and function 7 days after injury in a rat model of mild TBI, and an extension of the study showed that the animals treated with PEGbis-AA/HA-DXM had significantly improved motor function and reduced inflammatory response and lesion volume, making this a promising intervention strategy for TBI therapy.…”

Section: Brain Diseasesmentioning

confidence: 99%

Applications of Degradable Hydrogels in Novel Approaches to Disease Treatment and New Modes of Drug Delivery

Hu,

Gao,

et al. 2023

Pharmaceutics

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Hydrogels are particularly suitable materials for loading drug delivery agents; their high water content provides a biocompatible environment for most biomolecules, and their cross-linked nature protects the loaded agents from damage. During delivery, the delivered substance usually needs to be released gradually over time, which can be achieved by degradable cross-linked chains. In recent years, biodegradable hydrogels have become a promising technology in new methods of disease treatment and drug delivery methods due to their many advantageous properties. This review briefly discusses the degradation mechanisms of different types of biodegradable hydrogel systems and introduces the specific applications of degradable hydrogels in several new methods of disease treatment and drug delivery methods.

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Section: Brain Diseasesmentioning

confidence: 99%

Applications of Degradable Hydrogels in Novel Approaches to Disease Treatment and New Modes of Drug Delivery

Hu,

Gao,

et al. 2023

Pharmaceutics

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“…The initial trauma results in a primary injury that includes cerebral contusion, axonal shearing, and damage to vasculature [ 4 , 5 , 6 , 7 ]. This initial damage provokes the release of excitatory neurotransmitters, calcium influx into neurons, and the initiation of a secondary injury phase characterized by progressive neuroinflammatory responses that lead to delayed cell death and tissue damage [ 8 , 9 , 10 ]. The primary injury damage is rapid and is often considered as preventable but not treatable.…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone-Loaded Hydrogels Improve Motor and Cognitive Functions in a Rat Mild Traumatic Brain Injury Model

Macks

Jeong

Bae

et al. 2022

IJMS

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Functional recovery following traumatic brain injury (TBI) is limited due to progressive neuronal damage resulting from secondary injury-associated neuroinflammation. Steroidal anti-inflammatory drugs, such as dexamethasone (DX), can reduce neuroinflammation by activated microglia and infiltrated macrophages. In our previous work, we developed hydrolytically degradable poly(ethylene) glycol-bis-(acryloyloxy acetate) (PEG-bis-AA) hydrogels with dexamethasone (DX)-conjugated hyaluronic acid (HA-DXM) and demonstrated that dexamethasone-loaded hydrogels (PEG-bis-AA/HA-DXM) can reduce neuroinflammation, apoptosis, and lesion volume and improve neuronal cell survival and motor function recovery at seven days post-injury (DPI) in a rat mild-TBI model. In this study, we investigate the effects of the local application of PEG-bis-AA/HA-DXM hydrogels on motor function recovery at 7 DPI and cognitive functional recovery as well as secondary injury at 14 DPI in a rat mild-CCI TBI model. We observed that PEG-bis-AA/HA-DXM-treated animals exhibit significantly improved motor functions by the rotarod test and cognitive functions by the Morris water maze test compared to untreated TBI animals. We also observed that PEG-bis-AA/HA-DXM hydrogels reduce the inflammatory response, apoptosis, and lesion volume compared to untreated animals at 14 DPI. Therefore, PEG-bis-AA/HA-DXM hydrogels can be promising a therapeutic intervention for TBI treatment.

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Local delivery of RhoA siRNA by PgP nanocarrier reduces inflammatory response and improves neuronal cell survival in a rat TBI model

Macks

Jeong

Lee

2021

Nanomedicine: Nanotechnology, Biology and Medicine

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Effect of Early Correction of Hyponatremia on Neurological Outcome in Traumatic Brain Injury Patients

Cited by 4 publications

References 17 publications

Applications of Degradable Hydrogels in Novel Approaches to Disease Treatment and New Modes of Drug Delivery

Applications of Degradable Hydrogels in Novel Approaches to Disease Treatment and New Modes of Drug Delivery

Dexamethasone-Loaded Hydrogels Improve Motor and Cognitive Functions in a Rat Mild Traumatic Brain Injury Model

Local delivery of RhoA siRNA by PgP nanocarrier reduces inflammatory response and improves neuronal cell survival in a rat TBI model

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