Effect of early vs. late time-restricted high-fat feeding on circadian metabolism and weight loss in obese mice

Tsameret, Shani; Chapnik, Nava; Froy, Oren

doi:10.1007/s00018-023-04834-4

Cited by 4 publications

(2 citation statements)

References 56 publications

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“…In particular, compared with high-fat diet-fed mice, but similar to low-fat diet-fed mice, eTRF leads to reduced body weight, lipid profile, and inflammation in addition to enhanced insulin sensitivity and fat oxidation. These statistics emphasize the importance of timing meals compared with ad libitum food, especially during the first several hours of the activity period [93]. The effects of eTRF and lTRF on humans were evaluated in one of the first clinical trials (randomized crossover trial NCT02633722) designed for this purpose.…”

Section: Adf Alternate Day Fastingmentioning

confidence: 99%

Intermittent Fasting: Myths, Fakes and Truth on this Dietary Regimen Approach

Brogi,

Tabanelli,

Puca

et al. 2024

Preprint

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Intermittent fasting (IF) has been indicated as a valuable alternative to the classical caloric restriction dietary regimen for lowering body weight and preventing obesity-related complications such as metabolic syndrome and type II diabetes. However, is it effective? In this review article, we analyzed over 50 clinical studies in which IF, conducted by alternate day fasting (ADF) or time-restricted feeding (TRF), was compared with the caloric restriction approach. We evaluated the different roles of IF in treating and preventing human disorders such as metabolic syndrome, type II diabetes, and some types of cancer, as well as the usefulness of IF in reducing body weight and cardiovascular risk factors such as hypertension. Furthermore, we explored the cellular pathway targeted by IF to exert their beneficial effects by activating effector proteins that modulate cell functions and resistance to oxidative stress. In contrast, we investigated the concerns for human health related to the adoption of IF dietary regimen, highlighting the profound debate on weight loss regimens. We have examined and compared several clinical trials to formulate an updated conception regarding IF and its therapeutic potential.

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Section: Adf Alternate Day Fastingmentioning

confidence: 99%

Intermittent Fasting: Myths, Fakes and Truth on this Dietary Regimen Approach

Brogi,

Tabanelli,

Puca

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In particular, compared with high-fat diet-fed mice, but similar to low-fat diet-fed mice, eTRF leads to reduced body weight, lipid profile, and inflammation in addition to enhanced insulin sensitivity and fat oxidation. These statistics emphasize the importance of timing meals compared with ad libitum food, especially during the first several hours of the activity period [106]. The effects of eTRF and lTRF in humans were evaluated in one of the first clinical trials (randomized crossover trial NCT02633722) designed for this purpose.…”

Section: A General View Of If Approachesmentioning

confidence: 99%

Intermittent Fasting: Myths, Fakes and Truth on This Dietary Regimen Approach

Brogi,

Tabanelli,

Puca

et al. 2024

Foods

View full text Add to dashboard Cite

Intermittent fasting (IF) has been indicated as a valuable alternative to the classical caloric restriction dietary regimen for lowering body weight and preventing obesity-related complications, such as metabolic syndrome and type II diabetes. However, is it effective? In this review article, we analyzed over 50 clinical studies in which IF, conducted by alternate day fasting (ADF) or time-restricted feeding (TRF), was compared with the caloric restriction approach. We evaluated the different roles of IF in treating and preventing human disorders such as metabolic syndrome, type II diabetes, and some types of cancer, as well as the usefulness of IF in reducing body weight and cardiovascular risk factors such as hypertension. Furthermore, we explored the cellular pathways targeted by IF to exert their beneficial effects by activating effector proteins that modulate cell functions and resistance to oxidative stress. In contrast, we investigated concerns regarding human health related to the adoption of IF dietary regimens, highlighting the profound debate surrounding weight loss regimens. We examined and compared several clinical trials to formulate an updated concept regarding IF and its therapeutic potential.

show abstract