Effect of ecdysterone on hyperglycemia in experimental animals

Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals

“…injections of 0$5 mg/kg) may reduce hyperglycaemia induced by administration of glucagon or destruction (by alloxan treatment) of pancreatic islet b-cells in mice and rats (Yoshida et al 1971). Antidiabetic effects are also known for ecdysteroid-containing plants used in traditional medicine (e.g.…”

Phytoecdysteroids: Isolation and Biological Applications

“…Adaptogenic agents: possess adaptogenic, antidepressive, tonic, and roborant properties, i.e., they enhance the ability to cope with stress and enhance resistance to tiredness. Anti-diabetic agents: orally-supplied 20E reduces induced hyperglycaemia in rats (Kutepova et al, 2001), stimulates glucose incorporation into glycogen in mouse liver (Yoshida et al, 1971), and enhances glucose utilization by tissues in general (Syrov et al, 1997), by a mechanism that seems to enhance tissue sensitivity to insulin (Kosovsky et al, 1989). Hypocholesterolaemic agents: reduce cholesterol levels by reducing biosynthesis, enhancing its catabolism, and promoting conversion into bile acids (Syrov et al, 1986), producing hypocholesterolaemic (Lupien et al, 1969) and antiatherosclerotic (Syrov et al, 1983) effects.…”

Investigation of plants containing unusual ecdysteroids with ring in their side-chain

“…27,28 Ecdysteroids can reduce the hyperglycaemia induced by the administration of glucagon or alloxan. 29 Ecdysteroidcontaining plants are used in traditional medicine for their antidiabetic effect (e.g. Ajuga iva…”