Effect of egg yolk lecithins and commercial soybean lecithins on in vitro skin permeation of drugs

Mahjour, Majid; Mauser, Bernadette E.; Rashidbaigi, Z.; Fawzi, Mahdi B.

doi:10.1016/0168-3659(90)90164-o

Cited by 42 publications

(20 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This mechanism of action might be attributed to fatty acid ability to change the skin lipid fluidity, thus leading to an enhanced permeation absorption of drugs. 6,[19][20][21] Furthermore, enhancers may have the advantage of a shorter lag time after topical application. The lag time of cream with 5% enhancers of azone, menthol, lecithin and linoleic acid were 1 h, 1 h, 1 h and 2.0 h, respectively, showing that incorporated enhancers could shorten the lag time when compared with the formulation without enhancer (3.7 h).…”

Section: Resultsmentioning

confidence: 99%

“…[15][16][17][18] Both of them have also permeation enhancement effect for drugs such as piroxicam and ketoprofen. 6,[19][20][21] These four enhancers were used to improve the permeation of hesperetin in this study. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Azone has been shown to be effective in enhancing the permeability of many compounds through the stratum corneum. 19,[22][23][24] The mechanism of action of azone is suggested to influence the lipid fluidizing and to alter the keratin structure on stratum corneum lipids. 25) In this study, the 12 h cumulative amount for the control formulation was increased about 6.2 folds with incorporation of 5% azone.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The Effect of Component of Cream for Topical Delivery of Hesperetin

Huang

Lee

Huang

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Exposure of human skin to ultraviolet (UV) radiation may cause skin damage such as erythema and pigmentation, and acceleration of skin aging.1) Hyperpigmentation including melasma, freckles and senile lentiginoses is caused by the over-production of melanin, a pigment in the human skin acting as a major defense mechanism against UV light.2) However, hyperpigmentation on faces is a high anxiety-producing symptom for people from the aspect of beauty appearance. Nowadays, skin whitening agents, particularly natural antioxidants such as flavonoids, are receiving increasing attention because such flavonoids possess potential antioxidant activity and are claimed to be free of toxicity and side effects.3) Recently, much research has been focused on the potential use of flavonoids for preventive oxidative skin damage. [4][5][6] For skin bleaching, the topical delivery system is the considered administration route. Nevertheless, the most difficult aspect of a transdermal delivery system is to overcome the barrier of stratum corneum against foreign substances. Use of penetration enhancers is valuable and important for improving drug permeation, 7-9) but attention must be paid to the extensive damage to the skin caused by such enhancers, although the large increase in permeation rate is a positive. Therefore, optimal formulation design is important for topical application of pharmaceutical products.Flavanone compounds such as hesperetin (and its glycoside hesperidin) are a kind of flavonoid and have been reported to possess a wide range of pharmacological properties such as being anti-inflammatory and possessing enzymes (including hyaluronidase and xanthine oxidase) inhibitors, antimicrobial activity, UV protecting activity, along with analgesic and antioxidant effects.10) Moreover, hesperidin is extremely safe and without side effects even during pregnancy.10) The molecular weight of hesperetin is about 302, which makes it a good candidate for topical application. Therefore, the aim of this study was to design an optimal hesperetin cream which is the most common dosage forms for topical application. The in vitro permeation study was used to evaluate the effect of the composite on permeability of the drug through rat skin. In vivo studies such as skin whitening and irritation tests were used to assess the clinical usability of hesperetin cream. ExperimentalMaterials The following reagents were used: hesperetin, naringenin, menthol, linoleic acid, azone, methyl paraben, stearic acid and PEG-30 dipolyhydroxystearate (Tokyo Chemical Industry, Japan), cetyl alcohol (Acros, Belgium), lecithin (Wako, Japan), propylene glycol (PG), polyethylene glycols 400 (PEG 400) (Merck Chemicals, U.S.A.). Plush blush ® cream containing 1% ascorbyl magnesium phosphate (UNT, Taiwan). All other chemicals and solvents were of analytical reagent grade.Solubility Measurement An excess of hesperetin was placed in sealed glass tubes containing 2 ml of solvent. The tubes were shaken occasionally on a vortex mixer and were maintained at room temperatur...

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Component of Cream for Topical Delivery of Hesperetin

Huang

Lee

Huang

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

“…Although the exact mechanism of how lecithin causes skin alteration is not yet clearly understood, it is anticipated that it could be due to the interaction between the skin lipids and the lecithin's phospholipids. Mahjour et al ( 1990 ) studied the effects of commercial lecithin, Epikuron 135f (Lucas Meyer, Hamburg, Germany), in tetraglycol and egg yolk lecithin in propylene glycol on the in vitro permeation of procaterol, dextromethorphan, oxymorphone, and diphenhydramine using hairless mouse skin as a model membrane. Vehicles (tetraglycol and propylene glycol) without lecithin were considered as control.…”

Section: Mechanism Of Penetration Enhancement Of Lecithin Organogels mentioning

confidence: 99%

Lecithin Organogels in Enhancing Skin Delivery of Drugs

Shaikh

Jadhav

Kadam

2015

Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

View full text Add to dashboard Cite

“…Previous studies demonstrated that phospholipids exhibit their enhancing effect on the application of topical delivery. [14][15][16] Phospholipids are recognized to have skin permeation enhancing ability.…”

Section: Introductionmentioning

confidence: 99%

Topical delivery of DNA oligonucleotide to induce p53 generation in the skin via thymidine dinucleotide (pTT)-encapsulated liposomal carrier

Fang¹

2011

IJN

View full text Add to dashboard Cite

Introduction Transcription factor p53 has a powerful tumor suppressing function that is associated with many cancers. Since the molecular weight of p53 is 53 kDa, it is difficult to transport across cell membranes. Thymidine dinucleotide (pTT) is an oligonucleotide that can activate the p53 transcription factor and trigger the signal transduction cascade. However, the negative charge and high water solubility of pTT limit its transport through cellular membranes, thereby preventing it from reaching its target in the nucleus. A suitable delivery carrier for pTT is currently not available. Objective The purpose of this study was to employ a nanoscale liposomal carrier to resolve the delivery problem, and increase the bioavailability and efficiency of pTT. Methodology The approach was to employ liposomes to deliver pTT and then evaluate the particle size and zeta potential by laser light scattering (LLS), and permeation properties of pTT in vitro in a Franz diffusion assembly, and in vivo in a murine model using confocal laser scanning microscopy (CLSM). Results We found that dioleoylphosphatidylethanolamine (DOPE) combined with cholesterol 3 sulfate (C3S) were the best ingredients to achieve an average desired vehicle size of 133.6 ± 2.8 nm, a polydispersity index (PDI, representing the distribution of particle sizes) of 0.437, and a zeta potential of −93.3 ± 1.88. An in vitro penetration study showed that the liposomal carrier was superior to the free form of pTT at 2–24 hours. CLSM study observed that the penetration depth of pTT reached the upper epidermis and potential of penetration maintained up to 24 hours. Conclusion These preliminary data demonstrate that nanosized DOPE/C3S liposomes can be exploited as a potential carrier of drugs for topical use in treating skin diseases.

show abstract

Effect of egg yolk lecithins and commercial soybean lecithins on in vitro skin permeation of drugs

Cited by 42 publications

References 10 publications

The Effect of Component of Cream for Topical Delivery of Hesperetin

The Effect of Component of Cream for Topical Delivery of Hesperetin

Lecithin Organogels in Enhancing Skin Delivery of Drugs

Topical delivery of DNA oligonucleotide to induce p53 generation in the skin via thymidine dinucleotide (pTT)-encapsulated liposomal carrier

Contact Info

Product

Resources

About