Effect of eight prostaglandins on platelet aggregation

Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles

“…While various clinical treatments, such as vascular bypass surgery, have been developed for these diseases, the prognosis is still not good. Prostaglandin E 1 (PGE 1 ), which has various physiological actions, such as vasodilation, angiogenesis and inhibition of platelet aggregation, serves as an effective treatment for peripheral obstructive vascular diseases (20)(21)(22). However, when administered systemically, PGE 1 also has related adverse effects, such as hypotension and diarrhea (21,23).…”

Synthesis of Prostaglandin E1 Phosphate Derivatives and Their Encapsulation in Biodegradable Nanoparticles

“…Results from a number of clinical and animal studies support this notion (3)(4)(5). However, the range of activities of PGE 1 are also related to adverse effects (such as hypotension and diarrhea) due to its distribution throughout the body when administered systemically (4,6).…”

Prostaglandins

“…Many prostaglandins inhibit 4DP-induced platelet aggregation (343)(344)(345). Prostaglandin activation of adenyl cyclase is observed during aggregation, and it is proposed that this results in a transformation of the platelet into a sphere-like shape which is susceptible toward aggregation (341).…”