Effect of Electrical Stimulation of the Limbic System on Pituitary-Thyroidal Function

Shizume, Kazuo; Matsuzaki, Fumio; Uno, Satoru; Matsuda, Kōji; Nagataki, Shigenobu; Okinaka, Shigeo

doi:10.1210/endo-71-3-456

Cited by 14 publications

(4 citation statements)

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“…Electrical stimula tion of hippocampus in the rat is associated with increases in serum GH concentration [37], and hippocampal ablation slows down the rate of weight gain in young male animals [71] suggesting a facilitatory role of hippo campal formation in the control of GH secre tion and somatic growth in this species. Elec trical stimulation and ablation studies have, furthermore, implicated hippocampal forma tion in facilitation of thyroid hormone release in the dog [58], in inhibition of ovulation [39], in modulation of diurnal rhythms of glucocor ticoid secretion [45] in the rat, in maintenance of low basal glucocorticoid secretory rates in rats and cats [21,29,30], and in suppression of stress-induced glucocorticoid release in the rat [30], Presence of high density of gluco corticoid receptors in hippocampal tissue [38] prompted the idea that glucocorticoid uptake by hippocampal cells may serve as a negative feedback to its putative inhibitory function over glucocorticoid secretion, but hormone implantation in the hippocampus has yielded contradictory results [67], It would be of interest to determine whether the growth suppressing and GH-inhibitory functions of hippocampal formation (present study and Borer et al [11] and of the rostral medial septal area [9] are mediated by somato statin. Somatostatin was localized in or in the vicinity of both of these brain regions in the rat [1,2,13,20,51] and was shown to be a potent stimulant of pyramidal cell activity in the hippocampus [15].…”

Section: Discussionmentioning

confidence: 99%

Increased Serum Growth Hormone and Somatic Growth in Adult Hamsters with Hippocampal Transections

Borer¹,

Kelch²,

Peugh³

et al. 1979

Neuroendocrinology

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Somatic, endocrine, and behavioral correlates of growth and levels of voluntary running activity were measured in adult hamsters with hippocampal transections (HIPPO cuts) or in controls with transections of overlying cortex. Significant increase in serum concentration of growth hormone (GH) and decrease in pituitary concentration of GH were measured in HIPPO hamsters with a homologous radioimmunoassay method for hamster GH. HIPPO hamsters had increased: serum insulin concentration in fed state, food consumption, ponderal and linear growth, and percentage of body fat, and decreased levels of voluntary activity. Similarities between growth acceleration after HIPPO cuts and lesions of rostral medial septum suggest that fibers interconnecting, or passing through, the hippocampal formation and septum inhibit growth in adult hamsters.

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Section: Discussionmentioning

confidence: 99%

Increased Serum Growth Hormone and Somatic Growth in Adult Hamsters with Hippocampal Transections

Borer¹,

Kelch²,

Peugh³

et al. 1979

Neuroendocrinology

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“…However, thyroid activation has been demonstrated following hypothalamic stimulation, especially if the rabbit is adrenalectomized first (Harris & Woods, 1958). More recently, stimulation of the limbic area of the cerebral cortex in dogs has resulted in increased TSH secretion and thyroid activation (Shizume et al, 1962). Falconer & Hetzel (1964) were able to demonstrate rises in plasma PBI and PB131 in thyroid vein blood in the sheep when under restraint or exposed to a barking spaniel dog.…”

Section: Psychosocial Stressmentioning

confidence: 99%

The aetiology and pathogenesis of hyperthyroidism

Hetzel

1968

Postgraduate Medical Journal

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SummaryStudies of thyroid stimulating activity of serum from thyrotoxic patients has revealed an abnormal prolonged response in the mouse present in 40-60% of patients depending on the criteria used. This agent designated long acting thyroid stimulator (LATS) is a 7S globulin. Transplacental passage of LATS accounts for neonatal thyrotoxicosis-a self-limited disease. LATS is also more readily detected in patients with large goitre, exophthalmos, pretibial myxoedema and recurrence following therapy. Thyroid ablation is usually followed by a fall in the level of LATS. A fall may also be produced by steroid therapy or immunosuppressive agents. LATS probably arises from lymphoid tissue which accounts for the non-suppressibility of the hypersecreting thyroid. Its discovery provides strong evidence that hyperthyroidism is often, though not always, a disorder of immunological tolerance.

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“…TRH-induced increase in TSH as demonstrated by elevated 131I release yielded no significant changes in TBF (Campbell et al 1960;Shizume et al 1962); the TSH concentrations were not re¬ ported in these studies. Close correlation has been shown between TBF and serum TSH concentra¬ tions in rats after 10 days' methimazole administra¬ tion (Kapitola et al 1974).…”

Section: Discussionmentioning

confidence: 63%

“…A stimulatory effect of exogenous bovine TSH on the TBF has been reported in rabbits and cats (Söderberg 1958), dogs (Shizume et al 1962;Varga et al 1971), chick (Solomon et al 1963), and rats (Clayton 8c Szego 1967). Other investigators found no change in TBF after administration of TSH to rabbits (Campbell et al 1960;Taurog et al 1964), cats (Taurog et al 1964), dogs (Rosenberg et al 1960(Rosenberg et al , 1961Dumont & Rocmans 1964;Stark et al 1965;Isaacs et al 1966;Dumont 1971;Roc¬ mans et al 1978), or rats (Goldman 1963).…”

Section: Discussionmentioning

confidence: 93%

Human thyroid blood flow response to endogenous, exogenous human, and bovine thyrotrophin measured by electromagnetic flowmetry

Tegler¹,

Gillquist²,

Anderberg³

et al. 1981

Acta Endocrinologica

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Human thyroid blood flow (TBF) was studied with electromagnetic flowmetry during operation. Measurements were made of the effect on TBF of injections of bovine TSH into one inferior thyroid artery in 6 patients; 6 other patients were given human TSH, and in 10 patients measurements were made both of TBF and endogenous TSH released after administration of TRH in a peripheral vein.The TBF increased after all three types of injection. The mean of the TBF maxima after bovine TSH was 2.26 \ m=+-\ 0.35 (mean \ m=+-\sem) relative to basal TBF, after human TSH 1.97 \m=+-\0. 28, and after TRH 1.64 \ m=+-\0.20. In the three groups combined it was 1.92 \m=+-\0.16. The TBF was often increased already during the first recording period 1\p=n-\10min after TSH or TRH administration. The mean TBF was approximately doubled at 30\p=n-\50min. There were considerable inter-individual variations in the latent time and maximum response of TBF, especially after human TSH, but we found no correlation between the response and the TSH serum concentration in any group.A prompt, but inter-individually varying, increase in TBF was confirmed. This increase is suggested to be secondary to an increased intrafollicular metabolic activity and not primarily regulating the thyroid function.

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Effect of Electrical Stimulation of the Limbic System on Pituitary-Thyroidal Function

Cited by 14 publications

References 0 publications

Increased Serum Growth Hormone and Somatic Growth in Adult Hamsters with Hippocampal Transections

Increased Serum Growth Hormone and Somatic Growth in Adult Hamsters with Hippocampal Transections

The aetiology and pathogenesis of hyperthyroidism

Human thyroid blood flow response to endogenous, exogenous human, and bovine thyrotrophin measured by electromagnetic flowmetry

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