Effect of electromagnetic field and surface modification on the electrical behavior of novel solid lipid nanoparticles covered with l-arginine

Kuo, Yung‐Chih; Lin, Chan-Shing

doi:10.1016/j.colsurfb.2009.01.001

Cited by 17 publications

(6 citation statements)

References 34 publications

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“…Typically, the linear size of a particle ranges from 10 −3 to 10 μm and that of a pore from 10 −2 to 100 μm. The magnitude of the softness parameter λ −1 ranges from 0.1 to 10 nm. ,− The ranges of the relevant parameters considered later are based on these values. For illustration, two representative cases are examined, namely, the membrane layer is uncharged ( Q * = 0) and it is positively charged with Q * = 10.…”

Section: Resultsmentioning

confidence: 99%

Electrophoresis of a Membrane-Coated Cylindrical Particle Positioned Eccentrically along the Axis of a Narrow Cylindrical Pore

2010

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Although theoretical analyses on electrophoresis are ample in the literature, most of them focused on the one-or two-dimensional problems for a simpler treatment; available results for the three-dimensional case, which may be closer to reality, are extremely limited. The electrophoresis of a soft, finite cylindrical particle positioned eccentrically along the axis of a narrow cylindrical pore is modeled in this study. The type of particle considered is capable of mimicking a wide class of nonrigid entities such as biocolloids and particles covered by an artificial polymer layer in practice. The electrophoretic behaviors of the particle under various conditions are simulated. We show that if the membrane layer of a particle is charged, then its electrophoretic behavior depends largely on its aspect ratio, eccentricity, and relative size, the thickness of double layer, and the thickness of the membrane layer, which might not be the case if that layer is uncharged. In addition, the electrophoretic mobility of a particle in the former may not increase with increasing thickness of the membrane layer, which has not been reported previously. The results gathered provide the theoretical basis for both the design of an electrophoresis apparatus and the interpretation of experimental data.

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Section: Resultsmentioning

confidence: 99%

Electrophoresis of a Membrane-Coated Cylindrical Particle Positioned Eccentrically along the Axis of a Narrow Cylindrical Pore

2010

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“…In this study, four ionic species, including Tris + , Cl – , H + , and OH – , contributed to κ in Tris buffer and κ = 6.86 × 10 8 m –1 . The surface layer thickness of CSLNs was ∼4 nm . The core radii of CSLNs ranged from 83.5 to 271 nm, which were obtained by subtracting 4 nm from the D value (data shown in Figure ).…”

Section: Methodsmentioning

confidence: 70%

“…19 The surface layer thickness of CSLNs was ∼4 nm. 20 The core radii of CSLNs ranged from 83.5 to 271 nm, which were obtained by subtracting 4 nm from the D value (data shown in Figure 4). Hence, the cationic surface on CSLNs satisfied the assumption of a thin polyelectrolyte layer, that is,…”

Section: Methodsmentioning

confidence: 99%

Surface Molecular Composition and Electrical Property of Cationic Solid Lipid Nanoparticles with Assembled Lipid Layer Mediated by Noncovalent Interactions

Kuo

Wang

2012

J. Phys. Chem. C

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Understanding of charged groups on nanostructured lipid particles is an important issue in nanomedicine development. This study presents the relation between noncovalent interactions and the composition of ionogenic groups in the assembled lipid layer of cationic solid lipid nanoparticles (CSLNs). Innovated CSLNs containing cacao butter, cholesterol, stearylamine, and esterquat 1 (EQ 1) were fabricated by modified solvent diffusion method. The results revealed that the average diameter of CSLNs decreased when the weight percentage of cholesterol and EQ 1 increased. X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy evidenced strong interactions between cholesterol and EQ 1. These noncovalent interactions exhibited hydrophobic and cation–aromatic characteristics and mediated the distribution of lipids in the external layer of CSLNs. In addition, an increase in the weight percentage of cholesterol and EQ 1 enhanced the zeta potential, electrophoretic mobility, and fixed charge density on CSLNs. The noncovalent interactions in the assembled lipid layer affect the chemical composition on the lipid surface and yield intriguing electrokinetic behavior of CSLNs.

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“…This suggested that for a fixed amount of Tf, the mixed surfactants could combine the advantages of DODAB and future science group polysorbate 80 and improve the permeability of NVP across HBMECs. DODAB and polysorbate 80 could promote, respectively, adsorptive-mediated transcytosis by charge regulation and receptor-mediate transcytosis [79,87]. The related effects of surfactants on transcytosis were discussed as follows.…”

Section: Resultsmentioning

confidence: 99%

Targeting Nevirapine Delivery Across Human Brain Microvascular Endothelial Cells Using Transferrin-Grafted Poly(Lactide- Co -Glycolide) Nanoparticles

2011

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Effect of electromagnetic field and surface modification on the electrical behavior of novel solid lipid nanoparticles covered with l-arginine

Cited by 17 publications

References 34 publications

Electrophoresis of a Membrane-Coated Cylindrical Particle Positioned Eccentrically along the Axis of a Narrow Cylindrical Pore

Electrophoresis of a Membrane-Coated Cylindrical Particle Positioned Eccentrically along the Axis of a Narrow Cylindrical Pore

Surface Molecular Composition and Electrical Property of Cationic Solid Lipid Nanoparticles with Assembled Lipid Layer Mediated by Noncovalent Interactions

Targeting Nevirapine Delivery Across Human Brain Microvascular Endothelial Cells Using Transferrin-Grafted Poly(Lactide- Co -Glycolide) Nanoparticles

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