Palladium diselenide (𝑃𝑑𝑆𝑒 2 ) is a recently isolated layered material that has attracted a lot of interest for the pentagonal structure, the air stability and the electrical properties largely tunable by the number of layers. In this work, 𝑃𝑑𝑆𝑒 2 is used in the form of multilayer as the channel of back-gate field-effect transistors, which are studied under repeated electron irradiations. Source-drain 𝑃𝑑 leads enable contacts with resistance below 350 𝑘Ω • 𝜇𝑚. The transistors exhibit a prevailing n-type conduction in high vacuum, which reversibly turns into ambipolar electric transport at atmospheric pressure. Irradiation by 10 𝑘𝑒𝑉 electrons suppresses the channel conductance and promptly transforms the device from n-type to p-type. An electron fluence as low as 160 𝑒 − /𝑛𝑚 2 dramatically change the transistor behavior demonstrating a high sensitivity of 𝑃𝑑𝑆𝑒 2 to electron irradiation. The sensitivity is lost after few exposures, that is a saturation condition is reached for fluence higher than ∼ 4000 𝑒 − /𝑛𝑚 2 . The damage induced by high electron fluence is irreversible as the device persist in the radiation-modified state for several hours, if kept in vacuum and at room temperature. With the support of numerical simulation, we explain such a behavior by electron-induced Se atom vacancy formation and charge trapping in slow trap states at the 𝑆𝑖/𝑆𝑖𝑂 2 interface.