Effect of endotoxin on heart rate dynamics in rats with cirrhosis

Haddadian, Zahra; Eftekhari, Golnar; Mazloom, Roham; Jazaeri, Farahnaz; Dehpour, Ahmad Reza; Mani, Ali R.

doi:10.1016/j.autneu.2013.02.022

Cited by 34 publications

(42 citation statements)

References 37 publications

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“…The signals were digitized at a sampling rate of 10 kHz and displayed on a PowerLab system (ADInstruments, Australia). Before evaluation of the recorded atrial contractions, an equilibrium period of 30 min was allowed to prevent dissection-evoked artifact [22].…”

Section: Preparation Of Isolated Left Atria and In Vitro Studymentioning

confidence: 99%

Peroxisome Proliferator-Activated Receptor-α Inhibition Protects Against Doxorubicin-Induced Cardiotoxicity in Mice

et al. 2015

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Doxorubicin is an effective chemotherapeutic drug against a considerable number of malignancies. However, its toxic effects on myocardium are confirmed as major limit of utilization. PPAR-α is highly expressed in the heart, and its activation leads to an increased cardiac fatty acid oxidation and cardiomyocyte necrosis. This study was performed to adjust the hypothesis that PPAR-α receptor inhibition protects against doxorubicin-induced cardiac dysfunction in mice. Male Balb/c mice were used in this study. Left atria were isolated, and their contractility was measured in response to electrical field stimulation in a standard organ bath. PPAR-α activity was measured using specific PPAR-α antibody in an ELISA-based system coated with double-strand DNA containing PPAR-α response element sequence. Moreover, cardiac MDA and TNF-α levels were measured by ELISA method. Following incubation with doxorubicin (35 µM), a significant reduction in atrial contractility was observed (P < 0.001). Pretreatment of animals with a selective PPAR-α antagonist, GW6471, significantly improved doxorubicin-induced atrial dysfunction (P < 0.001). Furthermore, pretreatment of the mice with a non-selective cannabinoid agonist, WIN55212-2, significantly decreased PPAR-α activity in cardiac tissue, subsequently leading to significant improvement in doxorubicin-induced atrial dysfunction (P < 0.001). Also, GW6471 and WIN significantly reduced cardiac MDA and TNF-α levels compared with animals receiving doxorubicin (P < 0.001). The study showed that inhibition of PPAR-α is associated with protection against doxorubicin-induced cardiotoxicity in mice, and cannabinoids can potentiate the protection by PPAR-α blockade. Moreover, PPAR-α may be considered as a target to prevent cardiotoxicity induced by doxorubicin in patients undergoing chemotherapy.

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Section: Preparation Of Isolated Left Atria and In Vitro Studymentioning

confidence: 99%

Peroxisome Proliferator-Activated Receptor-α Inhibition Protects Against Doxorubicin-Induced Cardiotoxicity in Mice

et al. 2015

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“…Therefore, we wondered if abnormalities in skin temperature fluctuations may reflect abnormalities in core body temperature (CBT) regulation in these patients. To test this hypothesis, we analysed CBT data that we had previously recorded in control rats and rats with cirrhosis [3].Cirrhosis was induced by bile duct ligation and CBT was measured for six hours using an implanted telemetric probe [3]. The complexity of CBT fluctuations was quantified by multiscale entropy (MSE) analysis [4].…”

mentioning

confidence: 99%

“…Cirrhosis was induced by bile duct ligation and CBT was measured for six hours using an implanted telemetric probe [3]. The complexity of CBT fluctuations was quantified by multiscale entropy (MSE) analysis [4].…”

mentioning

confidence: 99%

Body temperature fluctuation analysis in cirrhosis

Mani

Mazloom

Haddadian

et al. 2017

Liver International

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We recently reported that patients with cirrhosis exhibit an abnormal pattern in their skin temperature variability, with complexity analysis of skin temperature fluctuations distinguishing inpatients from outpatients, despite similar mean temperature values [1]. Patients with cirrhosis also exhibit abnormalities in circadian rhythmicity, part of which are of central origin [2]. Therefore, we wondered if abnormalities in skin temperature fluctuations may reflect abnormalities in core body temperature (CBT) regulation in these patients. To test this hypothesis, we analysed CBT data that we had previously recorded in control rats and rats with cirrhosis [3]. This article is protected by copyright. All rights reserved

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“…The Poincaré plot shows the correlation between consecutive RR intervals [x-axis: RR (n): y-axis: RR (n + 1)]. The standard deviation of the points perpendicular to the line of identity (SD1) describes shortterm variability which is mainly related to the effects of respiration on vagal drive; the standard deviation along with the line of identity (SD2) describes the long-term RR interval variations and accounts for all other heart rate changes [18].…”

Section: Rem Sleep Deprivationmentioning

confidence: 99%

“…It is caused by an inhibition of the vagal tone during inspiration. The LF to HF ratio (LF/HF) was calculated as an index of the sympatho-vagal balance [18].…”

Section: Rem Sleep Deprivationmentioning

confidence: 99%

Does experimental paradoxical sleep deprivation (EPSD) is an appropriate model for evaluation of cardiovascular complications of obstructive sleep apnea?

Joukar

Ghorbani-Shahrbabaki

2015

Sleep Breath

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Purpose Some of the previous studies have used animal model of paradoxical sleep deprivation for investigation of sleep loss complications. The present study is designed to examine the effectiveness and reliability of this model for investigation and assessment of some cardiovascular complications of obstructive sleep apnea syndrome. Methods The Wistar rat groups were divided into the control group, the Test48 and Test72 groups, who experienced paradoxical sleep deprivation for 48 and 72 h, and the Sham48 and Sham72 groups, who were exposed to environmental conditions same to test groups but without sleep deprivation, respectively. At the end of the experiment, blood pressure and heart rate variability were assessed. ResultsThe results showed that 72 h rapid eye movements sleep deprivation significantly increased the systolic blood pressure compared to the control (p < 0.01), Sham48 and Test48 groups (p < 0.05). The comparison of the heart rate and heart rate variability parameters such as time domain indices (RR interval, SDNN, RMSSD, SD1, SD2, and SD1/ SD2) as well as frequency-domain variables (total power, LF and HF power, and LF/HF) had no significant difference among animal groups. Conclusions These findings suggest that rat paradoxical sleep deprivation may be a suitable model for induction and investigation of hemodynamic alterations which occurs in obstructive sleep apnea syndrome; however, it cannot be an alternative model to induce heart rate variability alterations similar to those reported in patient with obstructive sleep apnea.

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Effect of endotoxin on heart rate dynamics in rats with cirrhosis

Cited by 34 publications

References 37 publications

Peroxisome Proliferator-Activated Receptor-α Inhibition Protects Against Doxorubicin-Induced Cardiotoxicity in Mice

Peroxisome Proliferator-Activated Receptor-α Inhibition Protects Against Doxorubicin-Induced Cardiotoxicity in Mice

Body temperature fluctuation analysis in cirrhosis

Does experimental paradoxical sleep deprivation (EPSD) is an appropriate model for evaluation of cardiovascular complications of obstructive sleep apnea?

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