Effect of Enteral and Parenteral Nutrition on Amino Acid Levels in Cancer Patients

Pearlstone, David B.; Lee, Jong-Inn; Alexander, Richard; Chang, Tsung-Hung; Brennan, Murray F.; Burt, Michael

doi:10.1177/0148607195019003204

Cited by 22 publications

(8 citation statements)

References 12 publications

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“… 58 Moreover, a number of cachectic studies exhibited lower levels of circulating amino acids during cachexia in clinical as well as animal studies. 59 − 61 However, a downregulation of circulating branched-chain amino acids, which is thought to be a hallmark of cachexia, 62 was not observed in the current study. Accordingly, although it is unlikely that the observed shifts in circulating amino acids are due to cachexia, further evaluation is warranted.…”

Section: Discussioncontrasting

confidence: 80%

LC–MS Metabolomics of Psoriasis Patients Reveals Disease Severity-Dependent Increases in Circulating Amino Acids That Are Ameliorated by Anti-TNFα Treatment

et al. 2014

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Psoriasis is an immune-mediated highly heterogeneous skin disease in which genetic as well as environmental factors play important roles. In spite of the local manifestations of the disease, psoriasis may progress to affect organs deeper than the skin. These effects are documented by epidemiological studies, but they are not yet mechanistically understood. In order to provide insight into the systemic effects of psoriasis, we performed a nontargeted high-resolution LC–MS metabolomics analysis to measure plasma metabolites from individuals with mild or severe psoriasis as well as healthy controls. Additionally, the effects of the anti-TNFα drug Etanercept on metabolic profiles were investigated in patients with severe psoriasis. Our analyses identified significant psoriasis-associated perturbations in three metabolic pathways: (1) arginine and proline, (2) glycine, serine and threonine, and (3) alanine, aspartate, and glutamate. Etanercept treatment reversed the majority of psoriasis-associated trends in circulating metabolites, shifting the metabolic phenotypes of severe psoriasis toward that of healthy controls. Circulating metabolite levels pre- and post-Etanercept treatment correlated with psoriasis area and severity index (PASI) clinical scoring (R2 = 0.80; p < 0.0001). Although the responsible mechanism(s) are unclear, these results suggest that psoriasis severity-associated metabolic perturbations may stem from increased demand for collagen synthesis and keratinocyte hyperproliferation or potentially the incidence of cachexia. Data suggest that levels of circulating amino acids are useful for monitoring both the severity of disease as well as therapeutic response to anti-TNFα treatment.

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Section: Discussioncontrasting

confidence: 80%

LC–MS Metabolomics of Psoriasis Patients Reveals Disease Severity-Dependent Increases in Circulating Amino Acids That Are Ameliorated by Anti-TNFα Treatment

et al. 2014

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“…L-cysteine is manufactured by industrially used enzymatic process in which the thiazoline derivative DL-2-amino-2-thiazoline-4-carboxylic acid is converted with the help of three enzymes (L-ATC hydrolase, S-carbamoyl-Lcysteine hydrolase, and ATC racemase) from Pseudomonas thiazolinophilum (46).…”

Section: Production Of Amino Acids By Biotechnology Methodsmentioning

confidence: 99%

“…the major application of amino acids in human medicine is in transfusion, applied when oral consumption of proteinaceous food is not possible (36,39,46,55,56,59). These mixtures account for a small percentage of the total volume of amino acids sold each year (the main consumers of amino acids are the food flavoring industry and animal feed industry), but the requirement that they be highly purified provides a valueadded component (2).…”

Section: Introductionmentioning

confidence: 99%

Biotechnology in the Production of Pharmaceutical Industry Ingredients: Amino Acids

Ivanov

Stoimenova

Obreshkova

et al. 2013

Biotechnology & Biotechnological Equipment

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“…Only few randomised studies [15,16,49,64] have compared PN and EN (Table 1). It appears that PN was more effective than EN in promoting weight gain [49]even though this gain may be simply due to accrual of fat or water-and to maintain a better nitrogen balance and plasma amino acid level [49,64].…”

Section: Metabolic Effects Of Tube Feeding and Pnmentioning

confidence: 99%

Nutritional support in patients with oesophageal cancer

Bozzetti

2009

Support Care Cancer

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Effect of Enteral and Parenteral Nutrition on Amino Acid Levels in Cancer Patients

Abstract: Patients with esophageal cancer demonstrated significant alterations in amino acid profiles compared with those of normal controls. Total parenteral nutrition was superior to ad libitum oral feeding and jejunostomy feeding in repleting plasma amino acid levels.

Cited by 22 publications

References 12 publications

LC–MS Metabolomics of Psoriasis Patients Reveals Disease Severity-Dependent Increases in Circulating Amino Acids That Are Ameliorated by Anti-TNFα Treatment

LC–MS Metabolomics of Psoriasis Patients Reveals Disease Severity-Dependent Increases in Circulating Amino Acids That Are Ameliorated by Anti-TNFα Treatment

Biotechnology in the Production of Pharmaceutical Industry Ingredients: Amino Acids

Nutritional support in patients with oesophageal cancer

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