Effect of Environmental Change on Secondary Metabolite Production in Lichen-Forming Fungi

Deduke, Chris; Timsina, Brinda A.; Piercey‐Normore, Michele D.

doi:10.5772/26954

Cited by 26 publications

(14 citation statements)

References 148 publications

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“…Similarly, a significant decrease in the quantity of slazinic acid from southern to northern latitudes has been recorded for Xanthoparmelia viariduloumbrina [15]. Several studies have also demonstrated that the production of secondary metabolites in the lichens varied with changes in elevation.…”

Section: Quantification Of Usnic Acid By Hplcmentioning

confidence: 76%

“…It is reported that the usnic acid content of Flavocetraria nivalis thalli collected from 25 sites in northwestern Splitsbergen, Norway varied considerably between sites along local longitudinal and altitudinal transects [9]. Similarly, a significant decrease in the quantity of slazinic acid from southern to northern latitudes has been recorded for Xanthoparmelia viariduloumbrina [15]. Several studies have also demonstrated that the production of secondary metabolites in the lichens varied with changes in elevation.…”

Section: Quantification Of Usnic Acid By Hplcmentioning

confidence: 99%

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Elevational Trends in Usnic Acid Concentration of Lichen Parmelia flexilis in Relation to Temperature and Precipitation

Neupane

Malla

Gautam

et al. 2017

Climate

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Usnic acid contents in acetone extracts of 31 samples of lichen Parmelia flexilis collected from different altitudes were identified using thin layer chromatography (TLC) and determined by high performance liquid chromatography (HPLC). The usnic acid content varied in between highest 5.13% to lowest 1.66% in oven dried (80 • C) lichen samples. The species collected from lower altitudes all show high levels of usnic acid. The negative relationship between usnic acid and altitude was obtained. Statistically, it is revealed that there is a significant difference between average percentages of usnic acid in lichen samples with varying altitudes (p < 0.05). Beside these, the precipitation averages of the regions where the species have been collected were linked with the content of usnic acid. It is clear that lichens from the regions receiving the highest precipitation produced lower amounts of usnic acid. The results suggest that the production of secondary metabolite in lichens is altered due to the climatic variables like temperature and precipitation at different altitude gradients.

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Section: Quantification Of Usnic Acid By Hplcmentioning

confidence: 76%

Section: Quantification Of Usnic Acid By Hplcmentioning

confidence: 99%

Elevational Trends in Usnic Acid Concentration of Lichen Parmelia flexilis in Relation to Temperature and Precipitation

Neupane

Malla

Gautam

et al. 2017

Climate

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“…The secondary metabolites are generally produced by one of three major pathwayspolyketide, shikimic acid and mevalonic acid pathways (Scheme 2) (Chooi, 2008). The produced compounds are modified by various enzymes during the biosynthesis resulting in a highly diverse collection of molecules in both structure and function (Deduke et al, 2012). Therefore, dominance of secondary metabolites is various among species due to their different metabolism.…”

Section: Resultsmentioning

confidence: 99%

GC-MS analysis of Ramalina capitata (Ach.) Nyl. extract

Zrnzević

Zlatanović

Lazarević

et al. 2015

Facta Univ Phys Chem Technol

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This is the first report on the GC-MS profile of the ether-soluble fraction (ESF) of the methanol extract of the lichen Ramalina capitata (Ach.) Nyl. (Ramalinaceae). The profile was dominated by orcinol (22.9 %) and its monomethyl ether (30.9 %), which accounted for more than a half of the GC-MS analyzable fraction of ESF. Significantly lower amounts of structurally related sparassol (5.8%) and atraric acid (0.9 %) were also detected. Additionally, ESF contained methyl linoleate, methyl linolenate and methyl palmitate (17.3 %, 7.3 % and 5.0 %, respectively).

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“…It was probably combined with the different mycelial growth rates and Mnp activities caused by the manganese addition. It’s demonstrated that the metabolites may be influenced by the growth characteristic, growth stage, and postharvest condition (Kalač, 2013), and environmental alteration like increased manganese concentration is also likely to impact fungal growth, and influence the secondary metabolites (Deduke, Timsina & Piercey-Normore, 2012). The essential metals (e.g., copper, manganese, zinc) enter the fungal cells, and tend to biologically influence the fungal metabolic process (Hughes & Poole, 1991).…”

Section: Discussionmentioning

confidence: 99%

Manganese affects the growth and metabolism ofGanoderma lucidumbased on LC-MS analysis

Zhang

Zhou

et al. 2019

PeerJ

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Background As a metal-enriched edible fungus, Ganoderma lucidum is capable of adsorbing manganese effectively. And the manganese ion is demonstrated to play an important role in the synthesis of manganese peroxidase (Mnp) and other physiological activities during G. lucidum growth. Recently, the influence of manganese on the metabolites of G. lucidum fruiting bodies can be revealed through metabonomics technique. Methods In this study, we uncovered the changes between the control and 200 mg/kg Mn-treated fruiting bodies with liquid chromatography coupled to mass spectrometry (LC-MS). Results The mycelial growth rate, dry yield, Mnp activity , total polysaccharide content, triterpenoid content, and total manganese content in the mature fruiting bodies of G. lucidum changed between the control and different Mn-treated groups. Based on LC-MS method, a total of 16 significantly different metabolites were obtained and identified, among which, five presented significantly down-regulated and 11 up-regulated in Mn-treated samples. The metabolites chavicol and palmitoylethanolamide were particularly significantly up-regulated, and were found the strong promotion relationship. Dependent on the MetPA database, four KEGG pathways were detected and glycerophospholipid metabolism was most impacted, in which, choline was involved in. Discussion The added manganese ion in the substrate enhanced Mnp activities, and consequently promoted the mycelial growth, yield , metabolites in the fruiting bodies including triterpenoids, total manganese, chavicol, etc. Our finding can provide a theoretical reference to regulation of manganese on the physiological metabolism of G. lucidum.

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Effect of Environmental Change on Secondary Metabolite Production in Lichen-Forming Fungi

Cited by 26 publications

References 148 publications

Elevational Trends in Usnic Acid Concentration of Lichen Parmelia flexilis in Relation to Temperature and Precipitation

Elevational Trends in Usnic Acid Concentration of Lichen Parmelia flexilis in Relation to Temperature and Precipitation

GC-MS analysis of Ramalina capitata (Ach.) Nyl. extract

Manganese affects the growth and metabolism ofGanoderma lucidumbased on LC-MS analysis

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