1979
DOI: 10.1203/00006450-197902000-00004
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Effect of Epidermal Growth Factor on Lung Maturation in Fetal Rabbits

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Cited by 197 publications
(62 citation statements)
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“…Rabbit polyclonal antibodies to human PDGF-AA influence growth of airway epithelium (2,3), and insulin-like and PDGF-BB were from Genzyme (Boston, MA). Human growth factor has been localized to the respiratory epithelium (4, PDGF-AA and PDGF-BB were from 'pstate Biotechnology (Lake Placid, NY).…”
Section: Methodsmentioning
confidence: 99%
“…Rabbit polyclonal antibodies to human PDGF-AA influence growth of airway epithelium (2,3), and insulin-like and PDGF-BB were from Genzyme (Boston, MA). Human growth factor has been localized to the respiratory epithelium (4, PDGF-AA and PDGF-BB were from 'pstate Biotechnology (Lake Placid, NY).…”
Section: Methodsmentioning
confidence: 99%
“…Like Catterton et al (1979) we found no effect of EGF administration on fetal body weight and their lung weight in this experiment. EGF probably enhances differentiation of alveolar epithelial cells but does not inhibit the growth of fetal lung.…”
Section: Discussionmentioning
confidence: 55%
“…It might be, therefore, considered that EGF was incorporated into the littermates from EGF directly injected fetuses through placentas and consequently enhanced surfactant synthesis in their lung, but the mechanism was not clear. Catterton et al (1979) and Sundell et al (1980) have previously reported the positive effect of EGF on enhancing maturation of fetal lung in their animal experiments in vivo. However, Keller and Ladda (1981) of EGF on stimulating production of surfactant in vitro experiments in which pure cultures of pulmonary type II cells were made.…”
Section: Discussionmentioning
confidence: 99%
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“…EGF is known to promote fetal lung maturation (46)(47)(48)(49), and therapies used to accelerate it can increase both EGF levels in AF (50) and pulmonary EGF receptors (51). The time of gestation when EGF levels in AF increase has led to the speculation that it may be a marker of fetal lung maturation.…”
Section: Discussionmentioning
confidence: 99%