2008
DOI: 10.1248/bpb.31.250
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Effect of Eriobotrya japonica Seed Extract on 5-Fluorouracil-Induced Mucositis in Hamsters

Abstract: Frequent/massive administration of anticancer agents frequently causes mucositis. This condition involves the entire oral cavity in many cases, inducing pain and hemorrhage. Therefore, it decreases dietary intake, markedly reducing the quality of life (QOL). [1][2][3] In addition, severe mucositis influences the administration schedule of anticancer agents, affecting cancer treatment. Thus, it is important to prevent and treat chemotherapy-induced mucositis.Chemotherapy-induced mucositis is associated with two… Show more

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Cited by 20 publications
(21 citation statements)
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“…120 Plasma lipid peroxide levels were also decreased significantly in the same group. 120 Moreover, in a clinical trial, the severity of radiation-induced mucositis was attenuated in patients, as measured by significantly decreased serum interleukin-6 levels, following gargling and ingestion of indigowood root (Isatis indigotica Fort.). 121 In summary, certain plant extracts such as grape seed extract and Iberogast have revealed anti-inflammatory and antioxidant effects on chemotherapy-induced mucositis.…”
Section: Plant Extracts and Intestinal Mucositismentioning
confidence: 70%
“…120 Plasma lipid peroxide levels were also decreased significantly in the same group. 120 Moreover, in a clinical trial, the severity of radiation-induced mucositis was attenuated in patients, as measured by significantly decreased serum interleukin-6 levels, following gargling and ingestion of indigowood root (Isatis indigotica Fort.). 121 In summary, certain plant extracts such as grape seed extract and Iberogast have revealed anti-inflammatory and antioxidant effects on chemotherapy-induced mucositis.…”
Section: Plant Extracts and Intestinal Mucositismentioning
confidence: 70%
“…E. japonica seeds were extracted by 70% ethanol, as reported previously [3,8,9]. Briefly, E. japonica seeds (1.0 kg) were crushed in a blender equipped with a refrigerator at 1,000 rpm and then continuously stirred by a mixer at 300 rpm for 7 days after immersion in 70% ethanol.…”
Section: Plant Materials and Preparation Of Esementioning
confidence: 99%
“…The seeds also contain unsaturated fatty acids and vegetable sterols such as b-sitosterol [3]. Some of these compounds are biologically active, exhibiting antiallergic activity [5,6], antiinflammatory and immunosuppressive effects [5,[7][8][9], hypoglycemic activity [10], and ameliorative effects on hepatopathy [11] and nephropathy [12]. These effects are mainly achieved through the antioxidative activity of compounds in the seeds [12].…”
Section: Introductionmentioning
confidence: 99%
“…[22], sterols (b-sitosterol) [22], and polyphenols (caffeic acid, chlorogenic acid, etc.) [20,25], we speculate that polyphenols, which capture oxygen radicals such as OHÁ and O 2 Á-as radical scavengers, b-sitosterol, which protects cells by suppressing the overproduction of active oxygen species in various cells, and amino acids with biological function balancing effects are involved in complex manners. For the pharmaceutical preparation of ESE, we are evaluating deep sea water (DSW) as its vehicle.…”
Section: Introductionmentioning
confidence: 99%