Effect of estradiol of prostaglandin metabolism in rat uterus

Kuroda, Hiroshi; Yamada, Kenji; Aizawa, Yoshifusa

doi:10.1016/0090-6980(77)90252-0

Cited by 27 publications

(2 citation statements)

References 16 publications

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“…On the other hand, it has been observed that PGF content in rat uterus was increased on the day of proestrus when estrogen levels reached a maximum (20) and that PGF content in the uterus of ovari ectomized rat increased with estrogen treat ment (21). Moreover there was an increase in PGF level in the utero-ovarian vein after estrogen administration to guinea-pigs (11) and rats (22).…”

Section: Discussionmentioning

confidence: 80%

Effect of gonadotropin and estrogen on changes in levels of prostaglandin in rat ovary.

1981

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Abstract-Effects of gonadotropin and estrogen on the levels of pros taglandin (PG) in the rat ovary were investigated. PGF content in rat ovary, as measured by radioimmunoassay, was slightly higher than that by bioassay using rat stomach fundus, although there was no statistically significant difference.PGE and PGF levels in rat ovary during the estrous cycle were lowest on the day of diestrus, PGE was of the highest level on the day of estrus, and PGF on the day of proestrus.Both PGE and PGF were increased 24 hours after treatment with pregnant mare serum gonadotropin on the first day of diestrus.PGE was increased about 2.5 fold and PGF about 2.3 fold. PGF was significantly increased 24 hours after treament with estradiol on the first day of diestrus.These results suggest that gonadotropin may directly or indirectly regulate changes in ovarian PG content via actions of estrogen.

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Section: Discussionmentioning

confidence: 80%

Effect of gonadotropin and estrogen on changes in levels of prostaglandin in rat ovary.

1981

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“…Since follicular PG production is LH-dependent, it was of interest to ascertain whether exogenous progesterone inhibited PG synthesis in preovulatory follicles and, if *Reprint requests to: Dr Paul F. Terranova. so, to determine whether there was a differential effect on theca and granulosa cells. In addition, since oestradiol alters uterine PG metabolism (Ham et al, 1975;Kogo et al, 1977), the effects of reduced oestradiol and replacement therapy on follicular PGs after progesterone administration were also of interest.…”

Section: Introductionmentioning

confidence: 99%

Exogenous progesterone reduces follicular prostaglandin E and 6-keto prostaglandin F-1 in the cyclic hamster

Brannian

Terranova²

1990

Reproduction

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In cyclic hamsters, exogenous progesterone (100 micrograms) administered s.c. at 09:00 h on the day of dioestrus II reduced prostaglandin (PG) E and 6-keto PGF-1 alpha but not PGF concentrations in preovulatory follicles measured at 09:00 h of pro-oestrus. The injection of 10 micrograms ovine LH (NIADDK-oLH-25) concurrently with 100 micrograms progesterone on dioestrus II prevented the decline in follicular PGE and 6-keto PGF-1 alpha values. Administration of LH alone did not significantly alter follicular PG concentrations. Inhibition of follicular PGE accumulation by progesterone was due to a decline in granulosa PGE concentration and not thecal PGE. Progesterone administration also reduced follicular oestradiol concentrations. Administration of oestradiol-17-cyclopentanepropionate (ECP) (10 micrograms) with progesterone did not prevent the decline in follicular PGE and 6-keto PGF-1 alpha but did increase follicular PGF concentrations. However, ECP given alone on dioestrus II reduced follicular PGE and increased PGF concentrations in preovulatory follicles on pro-oestrus. It is concluded that exogenous progesterone administered on dioestrus II inhibits granulosa PGE and 6-keto PGF-1 alpha accumulation in preovulatory follicles, probably by reducing serum LH concentrations, and that the granulosa cells, which are LH-dependent, are a major source of follicular PGE.

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The Hormonal Control of Implantation

Aitken

1979

Novartis Foundation Symposia

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Effect of estradiol of prostaglandin metabolism in rat uterus

Cited by 27 publications

References 16 publications

Effect of gonadotropin and estrogen on changes in levels of prostaglandin in rat ovary.

Effect of gonadotropin and estrogen on changes in levels of prostaglandin in rat ovary.

Exogenous progesterone reduces follicular prostaglandin E and 6-keto prostaglandin F-1 in the cyclic hamster

The Hormonal Control of Implantation

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