Effect of Estrogens on Rat Serum Cholesterol Concentrations: Consideration of Dose, Type of Estrogen, and Treatment Duration*

Ferreri, L. F.; Naito, Herbert K.

doi:10.1210/endo-102-5-1621

Cited by 49 publications

(23 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This conclusion came in accordance with other results [27], which indicated that the increased triglycerides level in the serum of rats treated with estradiol may have resulted from an increase in hepatic synthesis of endogenous triglycerides which in turn released into the blood stream in the form of triglycerides rich very-low density lipoprotein. Other investigators have also remarked similar evidence that blood hypertriglycerides level resulted from treatment with estradiol could be attributed to increased secretion of hepatic triglyceride and decrease in its peripheral utilization.…”

Section: Discussionsupporting

confidence: 92%

Changes in Some Blood Lipid Fractions in Whole Body Irradiated Rats as Influenced by some Radioprotectors

Yousri

Roushdy

Gawish

1991

Isotopenpraxis Isotopes in Environmental and Health Studies

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Changes in Some Blood Lipid Fractions in Whole Body Irradiated Rats as Influenced by some Radioprotectors

Yousri

Roushdy

Gawish

1991

Isotopenpraxis Isotopes in Environmental and Health Studies

View full text Add to dashboard Cite

“…Consequently, the TC/HDL-C and HDL-C/LDL-C ratios were respectively lower and higher in EXEd rats than in sedentary rats as expected [21,26].…”

Section: Discussionsupporting

confidence: 74%

Exercise and Zoledronic Acid on Lipid Profile and Bone Remodeling in Ovariectomized Rats: a Paradoxical Negative Association?

Lespessailles

Jaffré

Rochefort

et al. 2010

Lipids

View full text Add to dashboard Cite

Exercise (EXE) and amino-bisphosphonates (BP) are both considered as useful strategies in the prevention of post-menopausal bone loss. Exercise reduces lipid levels, and BP may induce increase in high-density lipoprotein cholesterol (HDL-C). We hypothesized that combined effects of BP and exercise would produce a better improvement of lipid profile. We studied the specific and combined effects of zoledronic acid (Z) and EXE on lipid profile and bone remodeling in mature ovariectomized (OVX) rats. Six-month old female rats were randomly assigned to either a sham-ovx group (n = 12) or one of four OVX groups (n = 12): vehicle-treated sedentary (OVX); OVX + EXE (OVX-E, running on a treadmill for 12 weeks); OVX + Z (20 microg/kg, i.v.), (OVX-Z); OVX + Z+EXE (OVX-ZE). Total cholesterol (TC), HDL-C and bone remodeling markers were measured at baseline and at the end of the study. We demonstrated that both Z and EXE prevented the increase in bone resorption resulting from OVX, and individually improved the atherosclerotic risk index. Therapy with Z resulted in significant increase (39.00 +/- 0.03 vs. 53.6 +/- 0.01 mg/dl; +37.4%, P < 0.05) in serum concentration of HDL-C and a non significant decrease in TC (135.30 +/- 0.03 vs. 144.80 +/- 0.05 mg/dl; -5.8%) in the OVX-Z group compared to the OVX group. Post-menopausal women have elevated risk of CVD and bone resorption, hence, these data ultimately demonstrate (except for the elevated ratio in the combined group) that exercise and zoledronic acid are useful in minimizing the impact of these two processes in women and the combination of the two may be clinically relevant.

show abstract

“…Early studies in animals showed that pharmacological doses of 17·-ethinyl estradiol significantly reduced LDL cholesterol levels as a result of an increase in hepatic LDL receptor expression [4][5][6]. However it has been reported that the effect of estrogens on serum cholesterol is dependent not only on the dose, but also on the length of treatment and the type of estrogen [7]. In humans, the response of hepatic LDL receptor activity to estrogens has been less well docu- Owen/Roach/Abbey mented.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Low-Density Lipoprotein Receptor Activity by Estrogens and Phytoestrogens in a HepG2 Cell Model

Owen¹,

Roach²,

Abbey³

2004

Ann Nutr Metab

View full text Add to dashboard Cite

Background/Aims: Estrogen treatment is thought to lower low-density lipoprotein (LDL) cholesterol levels by increasing clearance through hepatic LDL receptors. This study aimed to determine the effect of estrogens and phytoestrogens on LDL receptor activity in a human hepatoma cell line, HepG2. Methods: HepG2 cells in culture were incubated for 24 h with estrogen or phytoestrogen and LDL receptor activity was measured by examining the cellular binding of colloidal gold-labelled LDL. Results: 17β-Estradiol significantly increased LDL receptor activity whereas estriol had negligible effects. Incubation with the isoflavonoids, formononetin, biochanin A and daidzein, caused significant elevations in receptor activity at concentrations above 40 µM. Coumestrol, a coumestan with a high level of estrogenic activity, caused a 3-fold increase in receptor activity at a concentration of 50 µM. Of the phytoestrogenic mammalian lignans enterolactone and enterodiol, only enterolactone displayed the ability to significantly upregulate LDL receptor activity at 50 µM. Conclusion: This study suggests that the LDL receptor-stimulating effect of natural estrogens is mainly due to estradiol and that the cholesterol-lowering effect of diets high in phytoestrogens may be due in part to their ability to increase hepatic LDL receptor activity.

show abstract

Effect of Estrogens on Rat Serum Cholesterol Concentrations: Consideration of Dose, Type of Estrogen, and Treatment Duration*

Cited by 49 publications

References 11 publications

Changes in Some Blood Lipid Fractions in Whole Body Irradiated Rats as Influenced by some Radioprotectors

Changes in Some Blood Lipid Fractions in Whole Body Irradiated Rats as Influenced by some Radioprotectors

Exercise and Zoledronic Acid on Lipid Profile and Bone Remodeling in Ovariectomized Rats: a Paradoxical Negative Association?

Regulation of Low-Density Lipoprotein Receptor Activity by Estrogens and Phytoestrogens in a HepG2 Cell Model

Contact Info

Product

Resources

About