Effect of ethanol consumption on colon cancer in an experimental model

Pérez-Holanda, S.; Rodrigo, Luís; Salas, Joan Viñas; Piñol-Felis, Carme

doi:10.4321/s1130-01082005000200003

Cited by 7 publications

(18 citation statements)

References 31 publications

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“…Various approaches have been used in animal models, including administration of a pro-carcinogenic agent to attempt to induce CRC development, as well as the use of genetically modified strains of mice that are prone to developing intestinal tumors (Hamilton, Sohn, & Fiala, 1987; Hayashi et al, 2007; Kushida et al, 2009; Pérez-Holanda, Rodrigo, Viñas-Salas, & Piñol-Felis, 2005; Perse & Cerar, 2007; Roy et al, 2002; Wimberly et al, 2013). Results from these studies vary considerably and many limitations have been reported with their use (Perse & Cerar, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effects of moderate alcohol consumption on gene expression related to colonic inflammation and antioxidant enzymes in rats

Klarich

Penprase

Cintora

et al. 2017

Alcohol

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Excessive alcohol consumption is a risk factor associated with colorectal cancer; however, some studies have reported that moderate alcohol consumption may not contribute additional risk for developing colorectal cancer while others suggest that moderate alcohol consumption provides a protective effect that reduces colorectal cancer risk. The purpose of this study was to determine the effects of moderate voluntary alcohol (20% ethanol) intake on alternate days for 3 months in outbred Wistar rats on risk factors associated with colorectal cancer development. Colonic gene expression of cyclooxygenase-2, RelA, 8-oxoguanine DNA glycosylase 1, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase M1, and aldehyde dehydrogenase 2 were determined. Blood alcohol content, liver function enzyme activities, and 8-oxo-deoxyguanosine DNA adducts were also assessed. Alcohol-treated rats were found to have significantly lower 8-oxo-deoxyguanosine levels in blood, a marker of DNA damage. Alanine aminotransferase and lactate dehydrogenase were both significantly lower in the alcohol group. Moderate alcohol significantly decreased cyclooxygenase-2 gene expression, an inflammatory marker associated with colorectal cancer risk. The alcohol group had significantly increased glutathione-S-transferase M1 expression, an antioxidant enzyme that helps detoxify carcinogens, such as acetaldehyde, and significantly increased aldehyde dehydrogenase 2 expression, which allows for greater acetaldehyde clearance. Increased expression of glutathione-S-transferase M1 and aldehyde dehydrogenase 2 likely contributed to reduce mucosal damage that is caused by acetaldehyde accumulation. These results indicate that moderate alcohol may reduce the risk for colorectal cancer development, which was evidenced by reduced inflammation activity and lower DNA damage after alcohol exposure.

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Section: Introductionmentioning

confidence: 99%

Effects of moderate alcohol consumption on gene expression related to colonic inflammation and antioxidant enzymes in rats

Klarich

Penprase

Cintora

et al. 2017

Alcohol

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“…España) por vía oral, a la dosis de 4 mg/kg peso al día; junto con etanol oral a la dosis de 1,23 g/kg peso al día; y ambos añadidos juntos al agua de bebida, desde el principio del estudio hasta el sacrificio; c) 30 ratas, tratadas con 18 dosis semanales de 21 mg/kg peso de dimetilhidracina (DMH; Fluka Chemica A.G., Sigma Co. ® , St. Louis, Mis-souri, EE.UU. ), administrado semanalmente (24,25), por vía subcutánea, desde el principio del estudio, junto con las mismas dosis de etanol y AUDC que B; d) 20 ratas, tratadas con ácido etilen-diamino-tetracético por vía subcutánea con el mismo volumen que C; y e) 20 ratas (grupo control DMH + etanol), con las mismas dosis de etanol e inyecciones de DMH que C.…”

Section: Materials Y Métodosunclassified

“…Las condiciones de habitabilidad fueron controladas (30,31). Los animales fueron separados en jaulas con un máximo de tres animales por jaula y sin juntar distintos sexos, para evitar la autofagia y agresiones (23)(24)(25)(26)(27).…”

Section: Materials Y Métodosunclassified

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Efecto del ácido ursodeoxicólico en un modelo experimental de cáncer de colon

Pérez-Holanda

Rodrigo

Salas

et al. 2007

Rev. esp. enferm. dig.

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El cáncer colorrectal (CCR) es un tumor muy frecuente que cursa con una elevada mortalidad en Occidente (1). En Asturias representa el 13% de los cánceres diagnosticados anualmente (2). Los factores ambientales juegan un papel destacado en su inducción (3); entre ellos, la dieta rica en grasas predispone al CCR, en parte debido a que aumentan la concentración de ácidos biliares secundarios en las heces, los cuales son promotores carcinogénicos (4,5). El ácido ursodeoxicólico (AUDC) se utiliza actualmente en terapéutica humana (6-10). Este ácido biliar ha

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“…Animal experiments are useful for examining the direct effects of alcohol; however, most experimental animal models have focused on high toxicological doses with forced and excessive ingestion involving intragastric ethanol infusion and liquid diets (10,11), and animal studies involving low alcohol consumption are limited. A study by Pérez-Holanda et al (12) indicated no significant effect of ethanol consumption (1.23 g/kg body weight/d) on the development of colon carcinogenesis in rats treated with the colon carcinogen 1,2-dimethylhydrazine (DMH) for 18 wk. However, they investigated the effect of only one dose of alcohol in rats.…”

mentioning

confidence: 99%

Consumption of Low-Dose of Ethanol Suppresses Colon Tumorigenesis in 1,2-Dimethylhydrazine-Treated Rats

Yang

Takahara

Kumrungsee

et al. 2019

J Nutr Sci Vitaminol

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The effect of low-dose of ethanol consumption on the development of colon cancer is unclear. This study aimed to investigate the effects of low-dose ethanol (0.5%, 1%, and 2% [v/v] ethanol in drinking water) for 28 wk on colon tumor incidence in rats injected with 1,2-dimethylhydrazine. Body weight, fluid and food consumption, and the total numbers of colon adenomas (mild-, moderate-, and severe-grade dysplasia) per rat were unaffected by ethanol consumption. However, the numbers of severe-grade dysplasia were significantly reduced by 1% ethanol compared with the control (0% ethanol; 293%) but not by 0.5% and 2% ethanol. Although the numbers of total adenocarcinomas were unaffected, those of total of adenomas and adenocarcinomas together were significantly reduced by 0.5% and 1% ethanol (239% and 241%, respectively). Intriguingly, real-time PCR assay indicated the abundance of cecal Clostridium leptum (a putative immunosuppressor) was the least in rats received 1% ethanol. Furthermore, 1% ethanol markedly increased colonic mRNA of IL-6, a putative suppressor of regulatory T-cells and cytoprotector. This study provides the first evidence for the potential of 1% ethanol, but not 2% ethanol, to prevent colon tumorigenesis in rats, supporting the J-curve hypothesis of the effect of low-dose alcohol on health. Further, the modulation of C. leptum and expression of IL-6, potentially linking to carcinogenesis, by 1% ethanol may provide an insight into the underlying mechanisms of the anti-colon tumor effect.

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Effect of ethanol consumption on colon cancer in an experimental model

Cited by 7 publications

References 31 publications

Effects of moderate alcohol consumption on gene expression related to colonic inflammation and antioxidant enzymes in rats

Effects of moderate alcohol consumption on gene expression related to colonic inflammation and antioxidant enzymes in rats

Efecto del ácido ursodeoxicólico en un modelo experimental de cáncer de colon

Consumption of Low-Dose of Ethanol Suppresses Colon Tumorigenesis in 1,2-Dimethylhydrazine-Treated Rats

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