Effect of Ethanol Extract Sonchus arvensis Linn Leaf on BUN, SCr, ALT, AST in Healthy Male Albino mice (Rattus norvegicus).

Harun, Nurhidayati; Indriastuti, Marlina; Fatimah, A.; Ega, Durga Shiva Prasad; Safitri, Yunita; Rosmayanti, M.

doi:10.1088/1742-6596/1179/1/012188

Cited by 3 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the orally consumed drugs undergo metabolism and excretion via liver and kidney, hence liver and kidney are always the target organs in oral toxicity [13]. Serum aspartate transaminase [14], Serum alanine transaminase (ALT), Serum alkaline phosphatase (ALP) are related to the hepatic cells functions, their measurement provides information on the nature of pathological damage to the tissue [15]. The daily oral administration of methanol extract of D.M stem bark for 28 days produce significant (p<0.05) decrease of ALT at all doses while ALP significantly (p<0.05) increased at 140 mg/kg.…”

Section: Effect Of Stem Bark Extract On Organ Weights After 28 Days Dmentioning

confidence: 99%

See 1 more Smart Citation

Biochemical and Histopathological Effect of Detarium microcarpum Stem Bark Extract in Wistar Albino Rats

Mu’azu

Baba

Matinja

2020

AJRB

View full text Add to dashboard Cite

Aim: In this study, the methanol stem bark extract of Detarium microcarpum was evaluated for sub-chronic, biochemical and histopathological studies. Methodology: Sub-chronic toxicity studies was investigated in rats administered with 35, 70 and 140 mg/kg doses of the extract orally for 28 days using standard laboratory procedures after the acute toxicity was carried out. Results: The median lethal dose (LD50) of the extract was calculated to be equal to (≥) 5000 mg/kg body weight in rats orally. Serological studies revealed significant (p<0.05) decrease in Alanine aminotransferase (ALT) at all doses tested, while at 140 mg/kg it caused a significant (p<0.05) increase in Alkaline Phosphatase (ALP). At doses of 70 and 140 mg/kg there was a significant (p<0.05) reduction in creatinine level. Histopathological studies on the liver showed moderate hepatocellular necrosis at doses of 35 and 70 mg/kg, while at 140 mg/kg there was intense hepatocellular necrosis, Kupffer cells and lymphocytes hyperplasia. The Kidney showed intense necrosis of tubules and glomerular necrosis with lymphocytes hyperplasia at all doses tested. The spleen also showed intense lymphocyte hyperplasia at all doses with sinusoidal congestion at the lowest dose of 35 mg/kg. The heart showed slight necrosis of cardiac muscle cells at all doses with blood congestion at 35 and 70mg/kg body weight. Conclusion: The study indicates that prolong use of the extract in the management of disease conditions may be associated with some adverse effect of some vital organs.

show abstract

Section: Effect Of Stem Bark Extract On Organ Weights After 28 Days Dmentioning

confidence: 99%

“…Sinusoidal congestion is often as a result of venous out flow occurred due to the impairment of small hepatic vein, large hepatic vein and the heart. The impairments indicate the toxic effect of the methanol extract on the spleen [14].…”

Section: Effect Of Detarium Microcarpum Stem Bark Methanol Extract Onmentioning

confidence: 99%

Biochemical and Histopathological Effect of Detarium microcarpum Stem Bark Extract in Wistar Albino Rats

Mu’azu

Baba

Matinja

2020

AJRB

View full text Add to dashboard Cite

show abstract

Rosella (Hibiscuss sabdariffa L) Extract Quality Test for Phase-1 Clinical Trials

Harun

Muhtadi

Nurmalasari

et al. 2020

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

The use of rosella extract administered to humans must pass the quality process test. This study is intended to prepare high quality rosella extract preparations based on Good Manufacturing Practice (GMP) which will be used in phase 1 clinical trials, including the standardization of the extract qualitatively, description of the sensory evaluation test, physicochemical, microbiological. The method used in the extraction process performed by solvent extraction method by maceration using ethanol in acidic conditions with a ratio of 4: 1. Determination of anthocyanin levels using the method of determining pH differentiation, to determine levels of flavonoids by using the aluminum chloride method, visual description sensory evaluation, and physicochemical. Then the microbiological test was conducted using the Total Plate Number (ALT) method. Screening shows rosella extract contains flavonoids and anthocyanins. Roselle extract contains anthocyanin at 10,6 mg/L and total flavonoids equivalent to quercetin 1,3 % w/w. The description sensory evaluation tests have a dark red, homogeneous appearance, smell and taste character like rosella. Physicochemical test results showed particle size 0,82 mm, water solubility 14,2%, alcohol solubility 5,6 %, loss on drying at a temperature of 70 °C at 9,8 %, density 0.72 g / ml, pH at 25 °C was 2.62. Rosella Extract free from aflatoxin and metal. The result test of microbiological aerobic plate count is <1,1E+3 cfu/g, Yeast and Mold <1,1E+3 cfu / g, Coliform APM negative, Salmonella sp negative, Shigella negative, Escherichia coli negative, Staphylococcus aureus negative, Pseudomonas aeruginosa negative. Conclusion, the qualitative test results of ethanol extract can be administered as ready-to-use products in phase 1 clinical trials.

show abstract

Effect of Tempuyung (Sonchus arvensis L.) Leaf Extract on Kidney Histology of Mice Exposed to Plasmodium berghei

Kusuma Wahyuni,

Putra Pradana,

Astuti Wahyuningsih

et al. 2023

RJPT

View full text Add to dashboard Cite

Plasmodium berghei is a parasite that causes complications or damage to the kidneys with elevated values of blood urea nitrogen (BUN) and creatinine in the blood. Tempuyung (Sonchus arvensis L.) leaf extract contains antioxidant compounds in the form of flavonoids which has the potential to reverse kidney damage. This study aimed to determine the effect of various doses of tempuyung leaf extract on kidney histology in mice exposed to Plasmodium berghei. This study used a completely randomized design method with 28 male BALB/c mice aged 6-8 weeks. They were divided into 7 treatment groups, namely KN (Normal Control), K+ (received 10mg/kg BW (bodyweight) of chloroquine diphosphate solution), K- (infected with P. berghei only), P1 (received 1 mg/kg BW of S. arvensis), P2 (10mg/kg BW of S. arvensis), P3 (received S. arvensis 100mg/kg BW), P4 (received S. arvensis 200mg/kg BW). Except in KN treatment group, all other treatment groups were infected with P. berghei .prior to oral administration of S. arvensis. The S. arvensis treatment was carried out for 7 days after which the blood serum was taken intracardially, and the kidneys were removed for histological studies. The results showed that tempuyung leaf extract had a significant effect on the repair of glomerular cells that experienced hydropic degeneration and necrosis but has no significant effect on glomerular atrophy. Thus, tempuyung leaves have the potential to reverse kidney complications caused by malaria.

show abstract

Effect of Ethanol Extract Sonchus arvensis Linn Leaf on BUN, SCr, ALT, AST in Healthy Male Albino mice (Rattus norvegicus).

Cited by 3 publications

References 2 publications

Biochemical and Histopathological Effect of Detarium microcarpum Stem Bark Extract in Wistar Albino Rats

Biochemical and Histopathological Effect of Detarium microcarpum Stem Bark Extract in Wistar Albino Rats

Rosella (Hibiscuss sabdariffa L) Extract Quality Test for Phase-1 Clinical Trials

Effect of Tempuyung (Sonchus arvensis L.) Leaf Extract on Kidney Histology of Mice Exposed to Plasmodium berghei

Contact Info

Product

Resources

About