Effect of ethanol on BOLD response to acoustic stimulation: implications for neuropharmacological fMRI

Seifritz, Erich; Bilecen, Deniz; Hänggi, Daniel; Haselhorst, Reta; Radü, E. W.; Wetzel, Stephan G.; Seelig, Joachim; Scheffler, Klaus

doi:10.1016/s0925-4927(00)00054-8

Cited by 58 publications

(28 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, task-related increases of the BOLD signal fMRI studies during recovery, as well as their reductions to physiological levels after 6–12 months may be partially addressed to CBF changes. Overall, longitudinal normalization of the BOLD signal is associated with good outcome [4], [52], [53], [54].…”

Section: Discussionmentioning

confidence: 95%

Interhemispheric Cerebral Blood Flow Balance during Recovery of Motor Hand Function after Ischemic Stroke—A Longitudinal MRI Study Using Arterial Spin Labeling Perfusion

et al. 2014

View full text Add to dashboard Cite

BackgroundUnilateral ischemic stroke disrupts the well balanced interactions within bilateral cortical networks. Restitution of interhemispheric balance is thought to contribute to post-stroke recovery. Longitudinal measurements of cerebral blood flow (CBF) changes might act as surrogate marker for this process.ObjectiveTo quantify longitudinal CBF changes using arterial spin labeling MRI (ASL) and interhemispheric balance within the cortical sensorimotor network and to assess their relationship with motor hand function recovery.MethodsLongitudinal CBF data were acquired in 23 patients at 3 and 9 months after cortical sensorimotor stroke and in 20 healthy controls using pulsed ASL. Recovery of grip force and manual dexterity was assessed with tasks requiring power and precision grips. Voxel-based analysis was performed to identify areas of significant CBF change. Region-of-interest analyses were used to quantify the interhemispheric balance across nodes of the cortical sensorimotor network.ResultsDexterity was more affected, and recovered at a slower pace than grip force. In patients with successful recovery of dexterous hand function, CBF decreased over time in the contralesional supplementary motor area, paralimbic anterior cingulate cortex and superior precuneus, and interhemispheric balance returned to healthy control levels. In contrast, patients with poor recovery presented with sustained hypoperfusion in the sensorimotor cortices encompassing the ischemic tissue, and CBF remained lateralized to the contralesional hemisphere.ConclusionsSustained perfusion imbalance within the cortical sensorimotor network, as measured with task-unrelated ASL, is associated with poor recovery of dexterous hand function after stroke. CBF at rest might be used to monitor recovery and gain prognostic information.

show abstract

Section: Discussionmentioning

confidence: 95%

Interhemispheric Cerebral Blood Flow Balance during Recovery of Motor Hand Function after Ischemic Stroke—A Longitudinal MRI Study Using Arterial Spin Labeling Perfusion

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Previous fMRI studies have shown the modulation of neuronal activation following acute alcohol ingestion in various types of crossover activation design with experimental tasks. These included auditory (Seifritz et al, 2000) and visual perception tasks (Calhoun et al, 2004a;Levin et al, 1998), goal-directed visuo-motor (Van Horn et al, 2006 and memory (Gundersen et al, 2008) tasks and even more complex scenarios like simulated driving (Allen et al, 2009;Calhoun et al, 2004b;Meda et al, 2009). Although previous studies have been extremely informative for visualizing alcohol effects on brain functionality and illustrating important implications of fMRI after drug administration, it has remained difficult in conventional task-based fMRI studies to determine whether differences in activation and taskby-drug interactions were due to a directly drug-affected brain function or to an altered behavioral performance secondary to an altered baseline state of the brain due to drug administration.…”

Section: Discussionmentioning

confidence: 99%

Alcohol increases spontaneous BOLD signal fluctuations in the visual network

et al. 2010

View full text Add to dashboard Cite

“…One has to estimate the peak time for the HRF and assume that it will be constant across all subjects and trials (113), anatomical regions (116), medications (90), ages (117), and vascular diseases (118), and that specific pathologies do not create a significant shift to the hemodynamic delay.…”

Section: Silent Event-related (Ser) (One Time-point) Methodsmentioning

confidence: 99%

Acoustic noise and functional magnetic resonance imaging: Current strategies and future prospects

Amaro

Williams

Shergill

et al. 2002

Magnetic Resonance Imaging

156

110

View full text Add to dashboard Cite

Functional magnetic resonance imaging (fMRI) has become the method of choice for studying the neural correlates of cognitive tasks. Nevertheless, the scanner produces acoustic noise during the image acquisition process, which is a problem in the study of auditory pathway and language generally. The scanner acoustic noise not only produces activation in brain regions involved in auditory processing, but also interferes with the stimulus presentation. Several strategies can be used to address this problem, including modifications of hardware and software. Although reduction of the source of the acoustic noise would be ideal, substantial hardware modifications to the current base of installed MRI systems would be required. Therefore, the most common strategy employed to minimize the problem involves software modifications. In this work we consider three main types of acquisitions: compressed, partially silent, and silent. For each implementation, paradigms using block and event-related designs are assessed. We also provide new data, using a silent event-related (SER) design, which demonstrate higher blood oxygen level-dependent (BOLD) response to a simple auditory cue when compared to a conventional image acquisition.

show abstract

Effect of ethanol on BOLD response to acoustic stimulation: implications for neuropharmacological fMRI

Cited by 58 publications

References 55 publications

Interhemispheric Cerebral Blood Flow Balance during Recovery of Motor Hand Function after Ischemic Stroke—A Longitudinal MRI Study Using Arterial Spin Labeling Perfusion

Interhemispheric Cerebral Blood Flow Balance during Recovery of Motor Hand Function after Ischemic Stroke—A Longitudinal MRI Study Using Arterial Spin Labeling Perfusion

Alcohol increases spontaneous BOLD signal fluctuations in the visual network

Acoustic noise and functional magnetic resonance imaging: Current strategies and future prospects

Contact Info

Product

Resources

About