Effect of Ethanol on Human Sleep EEG Using Correlation Dimension Analysis

Kobayashi, Toshio; Madokoro, Shigeki; Wada, Yuji; Misaki, Kiwamu; Nakagawa, Hiroki

doi:10.1159/000065420

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…Chaos analysis can quantify certain characteristics of the EEG that are not readily visible to a naked-eye examination. Towards this end, studies have been performed on EEGs obtained from both (a) normal states of the brain such as sleep 65 –73 and meditation, 74,75 as well as (b) pathological states such as schizophrenia 76 –80 and epilepsy. 57,81 –89…”

Section: Chaos Analysismentioning

confidence: 99%

Alzheimer's Disease: Models of Computation and Analysis of EEGs

2005

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In a recent article the authors presented a comprehensive review of research performed on computational modeling of Alzheimer's disease (AD) and its markers with a focus on computer imaging, classification models, connectionist neural models, and biophysical neural models. The popularity of imaging techniques for detection and diagnosis of possible AD stems from the relative ease with which neurological markers can be converted to visual markers. However, due to the expense of specialized experts and equipment involved in the use of imaging techniques, a subject of significant research interest is detecting markers in EEGs obtained from AD patients. In this article, the authors present a state-of-the-art review of models of computation and analysis of EEGs for diagnosis and detection of AD. This review covers three areas: time-frequency analysis, wavelet analysis, and chaos analysis. The vast number of physiological parameters involved in the poorly understood processes responsible for AD yields a large combination of parameters that can be manipulated and studied. A combination of parameters from different investigation modalities seems to be more effective in increasing the accuracy of detection-and diagnosis.

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Section: Chaos Analysismentioning

confidence: 99%

Alzheimer's Disease: Models of Computation and Analysis of EEGs

2005

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“…Ethanol caused a significant shortening of sleep latency in sleep-disturbed rats. On the other hand, it is reported that ethanol had no remarkable effect on sleep latency in healthy humans 7,8) ; however, there is no report whether ethanol showed a sleep-inducing effect in insomnia patients. Our present data in rats suggested that ethanol has the possibility of improving the insomniac's sleep.…”

Section: Discussionmentioning

confidence: 93%

“…4,6) On the other hand, there are many reports about the effect of ethanol on sleep latency and sleep pattern in healthy subjects or normal animals. [6][7][8] In connection with this, it is well known that many people who drink alcohol to help to fall asleep are not healthy but have trouble on sleeping. Therefore, there is a strong presumption that the effect of ethanol on insomniac patients is different from that in normal individuals.…”

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confidence: 99%

Effect of Ethanol on Sleep-Awake State in Sleep-Disturbed Rats

Obara

Tsutsui

Ishida

et al. 2010

Biological & Pharmaceutical Bulletin

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The present study was undertaken to investigate the effect of ethanol on the sleep-wake cycle in normal rats and sleep-disturbed rats. In normal rats, no significant difference was observed by ethanol in sleep latency, total awake time and total non-rapid eye movement (NREM) sleep time, except for total REM sleep time. On the other hand, in sleep-disturbed rats, ethanol at doses of 1 and 2 g/kg caused significant decreases in sleep latency and total wake time, and an increase in total NREM sleep time. In addition, ethanol showed a significant increase in delta activity in the sleep-disturbed model rat, different from triazolam. These results suggested that ethanol had not only a hypnotic but also a sleep-maintaining effect in sleep-disturbed rats at reasonable blood ethanol concentrations.

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“…Desta forma, em modelos farmacológicos de sono, o composto que interfere nesses dois parâmetros de forma signifi cativa, possui efeito hipnótico. Com relação a esse efeito, o conjunto de fl orais utilizado neste trabalho (White chestnut, Agrymony e Vervain), produziu de forma signifi cativa [(F = 10,30) Como os RFB utilizados na terapêutica são normalmente diluídos em substância alcoólica (Van Haselen, 1999), a qual possui efeitos hipnóticos (Kobayashi et al, 2002), um grupo controle, com brandy (teor alcoólico de 38% nos 0,45 mLs administrado aos animais), também foi avaliado. Interessantemente, verifi cou-se que não houve modifi cações nos parâmetros experimentais relacionados ao sono dos animais prétratados com brandy quando comparados com o controle, o qual recebeu apenas o veículo no qual os fl orais testados foram diluídos (água mineral).…”

Section: Resultsunclassified

Avaliação dos efeitos centrais dos florais de Bach em camundongos através de modelos farmacológicos específicos

De-Souza¹,

Garbeloto²,

Denez³

et al. 2006

Rev. bras. farmacogn.

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RESUMO: Os Remédios Florais de Bach (RFB), constituem um método alternativo de tratamento usado largamente na terapêutica de várias patologias em muitos países do mundo. Os RFB são reconhecidos como tratamento natural pela OMS desde 1956. Embora o mecanismo de ação dos RFB ainda não tenha sido elucidado, eles vêm sendo indicados para o tratamento de várias doenças neuropsiquiátricas. O objetivo do presente trabalho foi detectar possíveis efeitos centrais dos RFB em modelos farmacológicos utilizados na pesquisa de substâncias com efeitos ansiolíticos, hipnóticos, antidepressivos e neurolépticos. Para tanto, camundongos receberam um tratamento agudo via oral (0,45 mL) 1 hora antes dos testes. Os resultados mostraram que os fl orais Gorse e, em conjunto, White chestnut, Agrymony e Vervain exibiram perfi s antidepressivo e hipnótico, respectivamente. No modelo de ansiedade foi detectado efeito ansiolítico do fl oral Agrymony. Entretanto, não foram observados efeitos neurolépticos do fl oral Clematis. Os resultados nos levam a sugerir que os efeitos centrais dos fl orais avaliados podem ser parcialmente detectados através de modelos farmacológicos utilizados na pesquisa de agentes psicotrópicos. Unitermos: Remédios Florais de Bach (RFB), modelos farmacológicos, depressão, ansiedade, esquizofrenia, insônia. ABSTRACT: "Evaluation of central effects of Bach Flowers Remedies in mice using specifi c pharmacological models". The Bach Flowers Remedies (BFR's) are worldwide used as an alternative therapeutical approach for several pathologies, being considered by WHO as natural therapy since 1956. Despite the unknown mechanism of action, the BFR's have been widely used on treatment of several neuropsychiatry diseases. Based on pharmacological models used to detect ansiolitic, antidepressant, hypnotic and neuroleptyc effects of different substances, the aim of this work was to evaluate possible central effects of the BFR's. For this purpose, albino mice received BFR's treatment (0.45 mL) by oral route 1 hour prior to each test. The results revealed that the Gorse fl ower alone and a mix of White chestnut, Agrymony and Vervain showed antidepressant and hypnotic effects, respectively. On the anxiety model, Agrymony showed an ansiolitic effect but no neuroleptyc effects were observed for Clematis fl oral therapy. The herein described results allow us to conclude that the studied BFR's central effects may be partially detected through pharmacological models currently and widely used on psychotropic agents research.

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Effect of Ethanol on Human Sleep EEG Using Correlation Dimension Analysis

Cited by 10 publications

References 26 publications

Alzheimer's Disease: Models of Computation and Analysis of EEGs

Alzheimer's Disease: Models of Computation and Analysis of EEGs

Effect of Ethanol on Sleep-Awake State in Sleep-Disturbed Rats

Avaliação dos efeitos centrais dos florais de Bach em camundongos através de modelos farmacológicos específicos

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