Effect of Ethanol Root and Leave Extracts of Sida acuta on Some Kidney Function Indices and Electrolytes in Albino Wistar Rats

Nwankpa, Promise; Etteh, C.C.; Ekweogu, C.N.; Chikezie, Paul Chidoka; Chukwuemeka, O.G.; Egwurugwu, J. N.

doi:10.20546/ijcmas.2018.702.336

Cited by 5 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This increase in creatinine level may be as a result of glomerular inflammation. This result was in agreement with Nwankpa et al (2018) who stated that creatinine increase may have resulted from glomerular inflammation and interstitial nephritis.…”

Section: Discussionsupporting

confidence: 93%

The Effect of Ethanolic Extract of Justicia Secunda on Kidney Function in Female Wistar Rats

Victor

Ajie²,

Reuben³

et al. 2022

IJBS

View full text Add to dashboard Cite

Purpose: The kidneys serve as the excretory organ of the body. The assessment of serum creatinine, urea, and electrolytes (Na+, K+, HCO3-, Cl-) are crucial and sensitive biochemical markers that are usually involved in the diagnosis of renal impairments (Agbasi et al. 2010; Tietz, 2008; Yakubu et al. 2003). Methodology: Thirty-six animals were grouped into 6, with 6 rats in each group. The animals were housed at room temperature in metal cages. Animals in each group had access to clean water and commercial standard rodent pellets. Group 1 (control group) received distilled water, Groups 2-6 were treated orally with low, middle, and high doses of ethanolic extract of Justicia secunda leaves daily for 42 days. Findings: A significant increase in the level of urea concentration was observed compared to the control. From the present study, Na+, K+, Cl-, and HCO3 increased significantly in the moderate and high dose groups. Unique contribution to theory, policy and practice: In conclusion, this study indicates that ethanolic extract of Justicia secunda increased the serum level of urea, creatinine, and electrolytes.

show abstract

Section: Discussionsupporting

confidence: 93%

The Effect of Ethanolic Extract of Justicia Secunda on Kidney Function in Female Wistar Rats

Victor

Ajie²,

Reuben³

et al. 2022

IJBS

View full text Add to dashboard Cite

show abstract

“…This suggests either that the urea cycle may have been affected by plant extract leading to the reduction in the production of urea [10,27] or alkaloids and saponins contained in the plant extract [1,10] has produced systemic toxicity, invariably leading to reduced ability to excrete waste, and failure to maintain balance in body fluid and electrolytes [28]. Similar results were reported [29], on Alstonia boonei stem bark on Guinea pig and [30] on root and leave extracts of Sida acuta on wistar rats. Creatinine clearance in the glomerulus of the kidney is a useful tool to assessing the functionality of the kidney [31,32].…”

Section: Analytical Proceduresmentioning

confidence: 57%

“…The hypernatramic effect may be due to the excessive loss of water from the body fluid. From the result of this study, the concentration of potassium was not significantly decreased (P>0.05) which may confer the possibility of the hypernatraemic effect to the Na + /H + exchanger instead of Na + /K + pump [30,36]. The membrane-bound aldosterone regulates the absorption of sodium into the cell while Na + /K + pump may have been impaired on the administration of stem extract of Dennettia tripetala.…”

Section: Analytical Proceduresmentioning

confidence: 81%

Assessment of Kidney Function Indices in Male Albino Wistar Rats Administered Ethanol Stem Extract of Dennettia tripetala (Pepper fruit)

Nwankpa¹,

Cn²,

Egwurugwu³

et al. 2018

Biochem Pharmacol

View full text Add to dashboard Cite

“…The present report is similar to the reports by [55] who used fractions of the Sida acuta leaf extract and reported abnormal histomorphology of the kidney but no significant change in the serum electrolyte, urea and creatinine among treated rats. However, [65][66] reported mild changes in serum electrolytes, urea and creatinine in rats treated with ethanol extract of Sida acuta leaves.…”

Section: Discussionmentioning

confidence: 98%

Histopathologic and functional studies of the liver and kidneys of albino rats treated with ethanol crude extract of Sida acuta (wire weed) leaves in Nigeria

Ogu,

Azubuike

et al. 2024

JPAM

View full text Add to dashboard Cite

Article InformationMore than 80% of developing countries' populations depend on herbal medicine for their health care needs. Studies have revealed that Sida acuta is used for the treatment of various ailments. Hepatotoxicity and renal toxicity of ethanol crude extract of Sida acuta leaves in albino rats. Ethical approval was properly obtained. Twenty adult male albino rats were divided into 5 groups (A-E) of 4 rats per group. Groups A and B received water and 10% ethanol respectively and served as controls. Groups C-E received graded doses of the extract 50, 100 and 200 mg/kg body weight respectively via oral gavages for 21 days. Serum levels of total bilirubin, Alkaline Phosphatase (ALP), Aspartate Transaminase (AST) and Alanine Transaminase (ALT) were estimated for hepatotoxicity, while Serum urea and electrolytes (sodium, potassium, chloride and bicarbonate ions) were estimated for renal toxicity. The livers and kidneys were excised for subsequent histopathological processing and photomicrography. There was a statistically significant increase in the total bilirubin, AST, ALT and ALP reactivity among treated rats in groups C and D compared to controls, p = 0.04 respectively. There were no significant differences in the serum electrolytes and urea of treated groups compared to controls, p > 0.05. Histopathological changes were consistent with toxic injuries noticed on the liver and kidney tissues of the treated rats. In conclusion, the results revealed that prolonged oral intake of ethanol leaf crude extract of Sida acuta can exert hepatic and kidney damage on rats and can be extrapolated to men. There is a need for monitoring of Sida acuta use in humans.

show abstract

Effect of Ethanol Root and Leave Extracts of Sida acuta on Some Kidney Function Indices and Electrolytes in Albino Wistar Rats

Cited by 5 publications

References 12 publications

The Effect of Ethanolic Extract of Justicia Secunda on Kidney Function in Female Wistar Rats

The Effect of Ethanolic Extract of Justicia Secunda on Kidney Function in Female Wistar Rats

Assessment of Kidney Function Indices in Male Albino Wistar Rats Administered Ethanol Stem Extract of Dennettia tripetala (Pepper fruit)

Histopathologic and functional studies of the liver and kidneys of albino rats treated with ethanol crude extract of Sida acuta (wire weed) leaves in Nigeria

Contact Info

Product

Resources

About