Effect of ethanolic extract of leaves of Paederia foetida Linn. on acetic acid induced colitis in albino rats

Das, Swarnamoni; Kanodia, Lalit; Mukherjee, Arup; Hakim, Abdul

doi:10.4103/0253-7613.117728

Cited by 21 publications

(3 citation statements)

References 17 publications

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“…In addition, GIN extracts ameliorate colonic atrophy in DSS induced colitis in rats [11]. On the other hand, MOR leave extract improved DAI, macroscopic and microscopic lesion in acetic acid induced ulcer in rats [35]. While, MOR seed improves all signs of inflammation, and severity of colitis in acetic acid induced colitis in rats [36].…”

Section: Discussionmentioning

confidence: 99%

Possible Effects of Moringa oleifera versus Ginger (Zingiber officinalis) on Experimental Colitis in Mice

Elmasry

Daba

El-Karef

2016

BJMMR

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This work was carried out in collaboration between all authors. Author MHD designed the study, review the protocol, managed the experimental process and review manuscript. Author AE managed the literature searches, wrote the protocol, wrote the first draft of the manuscript, managed the experimental process and analyses of the study and performed the spectroscopy analysis. Author AAEK managed hisopathological and immunohistochemistery analysis and wrote its related part in the results. All authors read and approved the final manuscript.

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Section: Discussionmentioning

confidence: 99%

Possible Effects of Moringa oleifera versus Ginger (Zingiber officinalis) on Experimental Colitis in Mice

Elmasry

Daba

El-Karef

2016

BJMMR

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“…doses; significantly normalized its level. The standard drug GLB showed overall significant results 18 .…”

Section: Anti-pyreticmentioning

confidence: 98%

Untitled

2023

IJPSR

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Paederia foetida is one of the lesser-studied plants that has been utilized as food and medicine by several ethnic groups against stomach pain, bowel disease, snake bite, bone fractures burns, or scalding. Scientific research revealed that the plant exhibits extensive pharmacological activity, including antidiarrheal, antibacterial, anti-inflammatory, anti-diabetic, antiemetic, antioxidant and antirheumatoid. Based on the online poll results, information was acquired about P. foetida's transition from traditional use to scientific validation. Moreover, qualitative and quantitative phytochemical analysis of the plant indicates the presence of 36 important chemical constituents such as; methyl-mercaptan, phenolic, high percentage of minerals, urosolic acid, β-sitosterol, oleanolic acid, arachidic acid. The different phytoconstituents of the plant justify the ethno-medicinal and pharmacological application of the plant. In conclusion, the results of this analysis will produce a new, safe, and low-cost therapeutic strategy for identify and isolate novel chemical entities in drug discovery. Additionally, it may aid in separating fresh lead compounds for future clinical study research. This plant could be an excellent source of safe and effective medicinal and nutritional herbal remedies for human and animal consumption. INTRODUCTION:Over the past decades, Herbal and Ayurvedic drugs have been considered a subject of World importance with medicinal and economic implications 1 . Researchers are mainly focusing on the traditionally used medicinal plants by various ethnic groups to develop medication against different ailments. Paederia foetida is one of the most highly used medicinal plants mainly in the northeastern region of India and is well known for its gastro-protective and anti-diarrheal activity. It is widely available in India, Bangladesh, Japan,

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“…It is a climbing twining shrub with a bitter taste and foul smell, indigenous to the Indian subcontinent. The plant contains alkaloids (α and β-paederidine), sitosterol, vitamin Tassa BD (2023) -10.58920/sciphar02010022 https://etflin.com/sciphar 23 C, essential oils, and flavonoid (by the Shinoda test) (8). Traditionally the whole plant is used in rheumatic disease.…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic and Antioxidant Activities of Ethanolic Extract of Paederia foetida Leaves (EEPFL) in Albino Rats

Tassa

Sahu

Barman

et al. 2023

sciphar

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The present study was designed to evaluate the antihyperlipidemic and antioxidant activities of leaves of Paederia foetida (EEPFL). The ethanolic extract was obtained by infusion method, and acute oral toxicity tests were performed according to Organization for Economic Cooperation and Development, 2006 (OECD) guidelines. Hyperlipidemia was induced by feeding the rats with a high-fat diet consisting of coconut oil and vanaspati ghee in a ratio of 2:3 v/v at a dose of 10 ml/kg body weight. The extract was given at a dose of 500mg/kg body weight. Total cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol were measured for antihyperlipidemic activity. For antioxidant activity, Malondialdehyde (MDA), Catalase (CAT), and Superoxide Dismutase (SOD) were measured using standard methods. The extract showed a significant decrease in total cholesterol, triglycerides, LDL, and MDA in the blood. On the other hand, HDL, CAT, and SOD increased significantly. The study demonstrated that the ethanolic extract of leaves of Paederia foetida decreased blood lipid levels and lipid peroxidation. These findings suggest that the EEPFL may have potential therapeutic applications in the treatment of hyperlipidemia and oxidative stress-related diseases.

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Effect of ethanolic extract of leaves of Paederia foetida Linn. on acetic acid induced colitis in albino rats

Cited by 21 publications

References 17 publications

Possible Effects of Moringa oleifera versus Ginger (Zingiber officinalis) on Experimental Colitis in Mice

Possible Effects of Moringa oleifera versus Ginger (Zingiber officinalis) on Experimental Colitis in Mice

Untitled

Antihyperlipidemic and Antioxidant Activities of Ethanolic Extract of Paederia foetida Leaves (EEPFL) in Albino Rats

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