Effect of Ethanolic Extract of Pulverized Mangifera indica (Mango) Seed Kernel on Some Hematological Parameters in Normal and Monosodium Glutamate-Intoxicated Rats

Egbuonu, Anthony Cemaluk C.

doi:10.20431/2454-9444.0401006

International Journal of Research in Environmental Science

2018

DOI: 10.20431/2454-9444.0401006

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Effect of Ethanolic Extract of Pulverized Mangifera indica (Mango) Seed Kernel on Some Hematological Parameters in Normal and Monosodium Glutamate-Intoxicated Rats

Anthony Cemaluk C. Egbuonu¹

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Cited by 2 publications

References 37 publications

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Monosodium Glutamate Plus Artemether-lumefantrine Overdose Altered Malondialdehyde, Total Protein and Albumin Concentration in Rats

et al. 2019

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This study aimed at assessing alterations in malondialdehyde, MDA, total protein and albumin concentration in the serum and liver homogenate of monosodium glutamate (MSG)-challenged rats co-treated with artemether-lumefantrine, AL. Methods involving colourimetric estimation were employed in thirty rats randomly grouped into six (n = 5) and for seven consecutive days, fed feed and water (Group A), AL therapeutic dose (Group B), AL overdose (therapeutic dose × 5) (Group C), MSG (8000 mg/kg body weight) (Group D), AL therapeutic dose plus MSG (Group E) or AL overdose plus MSG (Group F). Total protein concentration (2.64±0.09 g/dL, 2.81±0.14g/dL, respectively) in the liver homogenate of rats exposed to MSG (group D) or MSG plus AL overdose (group F) and malondialdehyde concentration in the liver homogenate of MSG plus AL overdose-fed rats (0.45±0.04 mg/ml) lowered (P<0.05) as against other groups. However, serum albumin concentration in MSG (2.59±0.13 g/dl) or AL overdose plus MSG (3.24±0.12 g/dl) fed rats was higher (P<0.05) compared to the control (2.02±0.04 g/dl). The Total protein: Albumin ratio lowered while the Albumin: total protein ratio increased in rats in MSG, AL overdose plus MSG or AL overdose groups compared with the control. Thus, the apparent MSG plus AL overdose-induced adverse influence on the studied parameters and samples of non-malarial infested rats could be via compromised liver-mediated protein metabolism capacity and bio-functions following possibly enhanced protein-malondialdehyde adduct formation in the rats.

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Monosodium Glutamate Plus Artemether-lumefantrine Overdose Altered Malondialdehyde, Total Protein and Albumin Concentration in Rats

et al. 2019

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Artemether-lumefantrine Improved Superoxide Dismutase Co-regulation Related Antioxidant Defense in Monosodium Glutamate-induced Oxidative Stress in Rats

Cemaluk¹,

Chuk²,

Chibuzor³

et al. 2020

Asian J. of Biochemistry

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Effect of Ethanolic Extract of Pulverized Mangifera indica (Mango) Seed Kernel on Some Hematological Parameters in Normal and Monosodium Glutamate-Intoxicated Rats

Cited by 2 publications

References 37 publications

Monosodium Glutamate Plus Artemether-lumefantrine Overdose Altered Malondialdehyde, Total Protein and Albumin Concentration in Rats

Monosodium Glutamate Plus Artemether-lumefantrine Overdose Altered Malondialdehyde, Total Protein and Albumin Concentration in Rats

Artemether-lumefantrine Improved Superoxide Dismutase Co-regulation Related Antioxidant Defense in Monosodium Glutamate-induced Oxidative Stress in Rats

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