Effect of Ethanolic Extract of Embelia Ribes on Dyslipidemia in Diabetic Rats

Abstract

Diabetes mellitus has been treated orally with herbal remedies based on folk medicine since ancient times. Embelia ribes burm (Myrsinaceae), known commonly as vidanga, was used in Ayurveda for its anthelmintic activity. Ayurveda describes vidanga as pungent, causes increase in digestive fire, and cures flatulence and colic. A single study reported the antihyperglycemic activity of decoction of E. ribes in glucose-induced hyperglycemic albino rabbits. In the present study, the lipid-lowering and antioxidant potential of ethanolic extract of E. ribes burm was investigated in streptozotocin (40 mg/kg, IV, single injection)-induced diabetes in rats. Twenty days of orally feeding the extract (200 mg/kg) to diabetic rats resulted in significant ( P < 0.01) decrease in blood glucose, serum total cholesterol, and triglycerides, and increase in HDLcholesterol levels when compared to pathogenic diabetic rats. Further, the extract also lowered the liver and pancreas thiobarbituric acid-reactive substances (TBARSs) values ( P < 0.01) when compared to TBARS values of liver and pancreas of pathogenic diabetic rats. The results of test drug were comparable to gliclazide (25 mg/kg, orally), a standard antihyperglycemic agent. This is the first pilot study to provide biochemical evidence of potential of E. ribes in diabetic dyslipidemia. Keywords Diabetes; Dyslipidemia; Embelia ribes; Lipid Peroxidation; StreptozotocinAccording to the Framingham Heart Study [1], dyslipidemia, which can range from hypercholesterolemia to hyperlipoproteinemia, is one of the many modifiable risk factors for coronary artery disease (CAD), stroke, and peripheral vascular disease. In diabetic dyslipidemia, lipid abnormalities may be the result of unbalanced metabolic states of diabetes (i.e., hyperglycemia and insulin resistance).

Antidiabetic effects ofEmbelia ribesextract in high fat diet and low dose streptozotocin-induced type 2 diabetic rats

“…The administration of E. ribes extract for 21 days resulted in a significant reduction in fasting blood glucose levels. The observed antihyperglycemic effect of E. ribes extract is supported by our previous report (Bhandari et al 2002). E. ribes extract treatment also improved insulin sensitivity as evidenced by the OGTT results and HOMA-IR values.…”

“…In a preliminary study, Tripathi et al (1979) reported the anti-hyperglycemic activity of a decoction of E. ribes in glucose-fed albino rabbits. In addition, earlier studies in our laboratory showed that ethanolic extract of E. ribes produced antihyperlipidemic and antioxidant effect in streptozotocin (STZ)-induced type-1 diabetic rats (Bhandari et al 2002). Moreover, the effect of an ethanolic extract of E. ribes on tissue antioxidants, blood pressure and glycosylated hemoglobin was investigated in streptozotocin-induced oxidative damage in rats (Bhandari et al 2007(Bhandari et al , 2008.…”

Effect of dietary supplementation of ginger extract on growth, carcass characteristics and haematological parameters in broilers

“…Saeid et al (2010) observed that aqeous extract of ginger significantly reduced the level of cholesterol in the blood of broilers. Bhandari et al (1998) and Akhani et al (2004) also reported that ginger treatment significantly decreased serum cholesterol. The present experiment didn't check cholesterol level in the blood of broiler.…”

Evaluation of Growth Performance, Haematological and Serum Biochemical Response of Broiler Chickens to Aqueous Extract of Ginger and Garlic

“…Saeid et al (2010) observed that aqeous extract of ginger significantly reduced the level of cholesterol in the blood of broilers. Bhandari et al (1998) and Akhani et al (2004) Vol. 7, No.…”