Effect of etodolac, a new nonsteroidal anti-inflammatory drug, in MRL/lpr mice with articular lesions

Yoshida-Suzuka, Hirotsugu; Nakamura, Yutaka; Shibata, Yoshihisa; Kimura, K.

doi:10.1007/bf01986578

Cited by 4 publications

(5 citation statements)

References 14 publications

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“…The treatment with ER-34122 did not suppress serum RF levels nor enlargement of lymph nodes as shown in Table 2 and 3. Indomethacin also did not affect on RF levels or lymph nodes weight as reported previously [9,11].…”

Section: Discussionsupporting

confidence: 64%

“…Carlson et al reported that the severity and incidence of the arthritis was not affected by treatment with aspirin at the dose of 100 mg/kg/day [8], and Rordorf et al also reported indomethacin (0.5 and 1 mg/ kg/day) and piroxicam (0.5 mg/kg/day) were inactive in the arthritis [9,10]. It was also shown that indomethacin (1 mg/kg/day) could not suppressed indexes of synovial and subsynovial lesion [11]. Therefore, our results showing lack of suppressive effect of indomethacin (1 mg/kg/day) on indexes of late articular lesion are consistent with previous reports.…”

Section: Discussionmentioning

confidence: 89%

“…In this model, the disease expression is induced by the lpr gene, which is a deletion mutant of the Fas antigen [7], in the presence of an MRL genetic background. The effects of various anti-inflammatory drugs on indexes of articular lesion have been evaluated in the late stage of the MRL/l mice arthritis [8][9][10][11][12], but effects of NSAIDs including indomethacin on indexes of early articular lesion in MRL/l mice have not been reported. The articular lesions were analyzed histopathologically not only in the late stage but also in the early stage and marked inflammatory lesions such as PMN infiltration and subsynovial soft tissue edema in joints have been found in the early stage of this arthritis model [13].…”

Section: Introductionmentioning

confidence: 99%

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Effects of ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor, on indices of early articular lesion in MRL/MpJ-lpr/lpr mice

Horizoe

Nagakura

Chiba

et al. 1999

Inflammation Research

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Effects of ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor, on indices of early articular lesion in MRL/MpJ-lpr/lpr mice

Horizoe

Nagakura

Chiba

et al. 1999

Inflammation Research

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“…30 It was reported that COX-2 inhibitor, Nsaids, delayed the development of arthritis and reduced cartilage and bone damage using the MRL/lpr mice. 36 Therefore, the inhibition of Cox-2 may play an important role in the suppression of inflammation. In our study, the histopathological scores indicated that the inflammatory responses during synovitis may be inhibited by LIPUS treatment.…”

Section: Discussionmentioning

confidence: 99%

“…36 Tissue samples were dissected from knee joints after LIPUS treatment and examined by histopathological observation. Right knee joints (Fig.…”

Section: Antiarthritic Effect Of Lipus On the Mrl/lpr Micementioning

confidence: 99%

Low-Intensity Pulsed Ultrasound Reduces the Inflammatory Activity of Synovitis

et al. 2011

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The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) on the cell proliferation and growth of synovial membrane cells stimulated with inflammatory cytokines, and to evaluate the effectiveness of LIPUS treatment of synovitis in the knee joints of animal models for rheumatoid arthritis. The rabbit knee synovial membrane cell line, HIG-82, was cultured in medium with or without IL-1β or TNF-α. Four hours after stimulation with the cytokines, the cells received LIPUS or sham exposure. Cell proliferation and growth were then analyzed. Using MRL/lpr mice, the anti-inflammatory effects of LIPUS were also evaluated in vivo. Stimulation with proinflammatory cytokines significantly up-regulated cell proliferation which was significantly down-regulated by LIPUS exposure. In MRL/lpr mice, exposure of knee joints to LIPUS caused a significant reduction of histological damage compared to the control. Histological lesions were significantly reduced in the joints treated with LIPUS for 3 weeks. Cox-2-positive cells in the knee joints treated with LIPUS were markedly decreased compared to the control joints. Therefore, LIPUS stimulation may be a medical treatment for joint inflammatory diseases, such as synovitis.

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Effect of etodolac on type-II collagen-induced arthritis in mice

et al. 1993

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We tested the effect of etodolac on the development of type-II collagen-induced arthritis in DBA/1J mice. It was administered orally once daily for 35 days after the primary immunization with type-II collagen. Etodolac (10 mg/kg) significantly inhibited the development of signs of arthritis on day 28 to day 35. Indomethacin (1 mg/kg) also significantly inhibited it on day 29 to day 34. Radiographic examination showed that etodolac (10 mg/kg) significantly prevented the development of osteopenia, bone erosion and new bone formation of the joints on day 35, while indomethacin (1 mg/kg) significantly prevented only the development of bone erosion. Histopathological examination showed that both etodolac (10 mg/kg) and indomethacin (1 mg/kg) significantly prevented the development of synovitis, erosion of cartilage of the joints and bone destruction of the limbs on day 35. Etodolac and indomethacin did not affect the serum level of anti-type-II collagen antibodies. These results suggest that etodolac and indomethacin suppress type-II collagen-induced arthritis without affecting humoral immune responses.

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Effect of etodolac, a new nonsteroidal anti-inflammatory drug, in MRL/lpr mice with articular lesions

Cited by 4 publications

References 14 publications

Effects of ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor, on indices of early articular lesion in MRL/MpJ-lpr/lpr mice

Effects of ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor, on indices of early articular lesion in MRL/MpJ-lpr/lpr mice

Low-Intensity Pulsed Ultrasound Reduces the Inflammatory Activity of Synovitis

Effect of etodolac on type-II collagen-induced arthritis in mice

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