Effect of evening primrose oil supplementation on lipid profile: A systematic review and meta‐analysis of randomized clinical trials

Abstract

Background: Studies have shown that evening primrose oil (EPO) supplementation might be effective in improving lipid profile, however, the results are inconsistent. This study was performed to determine the direction and magnitude of the EPO effect on the lipid profile. Methods: PubMed, Scopus, Cochrane Library, Embase and Web of Science databases and Google Scholar were searched up to September-2019. Meta-analysis was performed using the random-effects model. Lipid profile including high-density lipoprotein (HDL), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) was considered as the primary outcome. Results: A total of 926 articles were identified through database searching, of which, six RCTs were included in the meta-analysis. There were six studies on HDL, TC, and TG and four studies on LDL. EPO supplementation had no significant effect on TC, TG, LDL,

Phytonutrient supplements and metabolic biomarkers of cardiovascular disease: An umbrella review of meta‐analyses of clinical trials

“…Thirteen of these studies were excluded because they included an abstract ( N = 5) or a protocol ( N = 1) only, were not published in English ( N = 1), had inappropriate exposures ( N = 2) or outcomes ( N = 1), or did not provide updated data ( N = 2). As a result, 50 systematic reviews and meta‐analyses were included in the final analysis (Figure 1; Amir Shaghaghi et al, 2013; Askari et al, 2019; Azhdari et al, 2019; Chen et al, 2020; Fatahi et al, 2019; Ghaedi et al, 2019; Ghaedi et al, 2020; Glisic et al, 2018; Gui et al, 2016; Hadi et al, 2018, 2020; Hadi, Pourmasoumi, Mohammadi, et al, 2019; Hadi, Pourmasoumi, Najafgholizadeh, et al, 2019; Hallajzadeh et al, 2020; Hamedifard et al, 2019; Han et al, 2019; Hasani et al, 2019; Hemati et al, 2020; Hernández‐García et al, 2019; Heshmat‐Ghahdarijani et al, 2020; Karimian et al, 2019; Khorshidi et al, 2020; Li et al, 2014, 2015, 2020; Maierean et al, 2017; Mansour‐Ghanaei et al, 2018; Mohammadi, Hadi, et al, 2019; Mohammadi, Ramezani‐Jolfaie, et al, 2019; Ostadmohammadi et al, 2019; Pourmasoumi et al, 2018, 2020; Rahmani et al, 2019; Rahmani et al, 2020; Ricci et al, 2010; Ried, 2016; Rocha et al, 2019; Sahebkar, 2014; Sahebkar, Simental‐Mendía, et al, 2016; Sahebkar, Soranna, et al, 2016; Salehi‐Sahlabadi et al, 2020; Serban et al, 2015; Shekarchizadeh‐Esfahani et al, 2020; Taku et al, 2010; Ursoniu et al, 2018; Zhang et al, 2020; Zhang, Yuan, et al, 2016; Zhang, Liu, et al, 2016; Zhu et al, 2017; Ziaei et al, 2020).…”

Therapeutic efficacy of Urtica dioica and evening primrose in patients with rheumatoid arthritis: A randomized double-blind, placebo-controlled clinical trial

“…EPO is more known for its effects on systemic chronic in ammatory conditions, such as atopic dermatitis and RA. Hence, the signi cant decrease of the in ammatory parameters after GLA supplementation was expected (Khorshidi et al, 2020).…”

Evening primrose seed extract rich in polyphenols modulates the invasiveness of colon cancer cells by regulating the TYMS expression

“…Human studies proposed doses ranging from 160 mg daily to 4 g daily. 29,30 We have proposed the following treatment regime based on the literature and achieved solubility. Starting from the end of the seventh week, the EPE (dissolved in dimethyl sulfoxide (DMSO), and further diluted with 0.9% NaCl solution to a final concentration of 5% DMSO) was administered intrarectally at the dose of 1.025 mg or 10.25 mg in the final volume of 100 μL every three days until the end of 14 weeks.…”