Effect of exenatide, metformin and folic acid on experimentally induced metabolic–cognitive syndrome in rats

Bahriz, Ahmed; Mansour, M. A.; Ibrahim, Amany; Khalil, Doaa; Elnoury, Heba A.

doi:10.21608/bmfj.2020.86396

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…This was in line with the study of Ma et al ( 2013), (23) who revealed that the oat intake significantly reduced the HOMA-IR value in comparison with the base line. Also, the result was in agreement with the study of Bahriz et al (2020), (24) illustrated that the all-treated rats with metformin resulted in decrease in HOMA-IR index. The lowest levels of TC and LDL-C in the study were shown in the experimental groups fed on oat, which were in comparison with the other groups that fed on rodent pellets.…”

Section: Discussionsupporting

confidence: 92%

Efficacy of Avena Sativa on Regulating Some Biochemical Parameters in Type 2 Diabetic Male Albino Rats

Ghaly

Ismael

Khamis

et al. 2022

Journal of High Institute of Public Health

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Background: Avena sativa has been recognized as a healthy and nutritious cereal, containing a high concentration of dietary fiber and dense nutrients. Many scientific research studies linked oats as a healthy diet in the fight against Type 2 Diabetes Mellitus (T2DM). Objective(s):This study aims to assess the proximate analysis of Avena Sativa (oats) cultivated in Egypt to evaluate its main nutrient content, and study its effect on blood glucose homeostasis, lipid profile and antioxidant enzymes in type 2 diabetic rats. Methods: Proximate analysis was measured in oats using standard methods. A total of fifty rats grouped into 10 control rats and four groups of 40 diabetic rats were included in the study. The four diabetic groups were classified into the diabetic control group, and the three experimental groups one of them treated with 200 mg/kg Metformin, the other fed on oat grains only as the main diet and the last one fed on oat grains and treated with metformin. Results: Oats are rich in dietary fibers, fat, and protein (9.3, 8.75, and 14.12% respectively). Treatment with metformin and oats showed an improvement in blood glucose homeostasis including FBG, insulin, 12.44, and 3.92 respectively). Lipid profile showed a statistical change among all studied groups. The lowest decrease in lipid profile (LDL and TC) was in the combined group (79.56 and 151.4 respectively). Conclusion: Chemical analysis of oats revealed that it's a good source of the main nutrients, containing protein and fibers compared to standard pellets. In addition, it has a promoting healthy effect on blood levels of fast glucose, insulin, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), and malondialdehyde (MDA). Oats revealed a modulatory curative effect on the diseased liver and pancreatic tissues.

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Section: Discussionsupporting

confidence: 92%

Efficacy of Avena Sativa on Regulating Some Biochemical Parameters in Type 2 Diabetic Male Albino Rats

Ghaly

Ismael

Khamis

et al. 2022

Journal of High Institute of Public Health

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“…• Diabetic group receiving metformin (group IV): 250 mg/kg/ day of metformin was administered orally for 4 weeks (Bahriz et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

Telmisartan versus metformin in downregulating myostatin gene expression and enhancing insulin sensitivity in the skeletal muscles of type 2 diabetic rat model

Abd-Eltawab Tammam,

Rizg,

Fakhry Boushra

et al. 2023

Front. Pharmacol.

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Objective: Telmisartan is an angiotensin receptor blocker (ARB) that specifically blocks angiotensin II type-1 receptors (AT1R). Telmisartan has been proven to have antidiabetic effects via a variety of mechanisms, and it can be utilized in some diabetic patients due to its dual benefit for hypertensive patients with type 2 DM (T2DM) and when the other oral antidiabetic medications are intolerable or contraindicated. However, its precise underlying hypoglycemic mechanism is still obscure.Aim of work: We sought to establish a link between telmisartan administration and myostatin expression in skeletal muscles of T2DM rat model as a potential hypoglycemic mechanism of telmisartan.Materials and Methods: 32 male albino rats were included in the study; 8 rats served as controls (group I). T2DM was inducted in the other 24 rats, which were then randomly subdivided into 3 groups (8 in each): (group II) the Diabetic group and (groups III and IV) which were treated with either telmisartan (8 mg/kg/day) or metformin (250 mg/kg/day) respectively via oral gavage for a 4-week period.Results: Telmisartan administration resulted in a significant improvement in OGTT, HOMA-IR, glucose uptake, and muscle mass/body ratios in Telmisartan group as compared to Diabetic group (p < 0.05). Additionally, telmisartan induced a significant boost in adiponectin and IL-10 serum levels with a substantial drop in TNF-α and IL-6 levels in Telmisartan group compared to diabetic rats (p < 0.05). Moreover, telmisartan significantly boosted SOD and GSH, and decreased MDA levels in the skeletal muscles of telmisartan group. Furthermore, a significant downregulation of myostatin and upregulation of insulin receptor, IRS-1, and IRS-3 genes in the skeletal muscles of Telmisartan group were also detected. Histologically, telmisartan attenuated the morphological damage in the skeletal muscle fibers compared to diabetic rats, as evidenced by a considerable decrease in the collagen deposition area percentage and a reduction in NF-kB expression in the muscle tissues of group III.Conclusion: Telmisartan administration dramatically reduced myostatin and NF-kB expressions in skeletal muscles, which improved insulin resistance and glucose uptake in these muscles, highlighting a novel antidiabetic mechanism of telmisartan in treating T2DM.

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Effect of exenatide, metformin and folic acid on experimentally induced metabolic–cognitive syndrome in rats

Cited by 2 publications

References 56 publications

Efficacy of Avena Sativa on Regulating Some Biochemical Parameters in Type 2 Diabetic Male Albino Rats

Efficacy of Avena Sativa on Regulating Some Biochemical Parameters in Type 2 Diabetic Male Albino Rats

Telmisartan versus metformin in downregulating myostatin gene expression and enhancing insulin sensitivity in the skeletal muscles of type 2 diabetic rat model

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