Effect of exercise and grape juice on epigenetic modulation and functional outcomes in PD: A randomized clinical trial

Oliveira, Grazielle Silva De; Iraci, Lucio; Pinheiro, Gislaine S.; Casal, Marcela Zimmermann; Haas, Aline Nogueira; Pochmann, Daniela; Martinez, Flávia Gomes; Elsner, Viviane Rostirola; Dani, Caroline

doi:10.1016/j.physbeh.2020.113135

Cited by 15 publications

(14 citation statements)

References 45 publications

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“…The participants who met the inclusion criteria were randomized into an intervention group (aquatic exercise program þ grape juice consumption, ACQ-EXE þ GJ) or control group (aquatic exercise program, without grape juice, ACQ-EXE) by a researcher who did not participate in the collections, through the website randomization.com [35]. The evaluation of cognitive function and anthropometric variables as well blood collection for oxidative stress measurement was done before and after intervention.…”

Section: Methodsmentioning

confidence: 99%

“…3.190. 828) and also was registered by ReBEC clinical trial (RBR-2c4xxb) [35]. An informed consent was provided and signed before the protocol began and the investigation was in full compliance with the Helsinki Declaration.…”

Section: Ethical Considerationsmentioning

confidence: 99%

“…All methods were performed following the relevant guidelines and regulations. Written informed consent was obtained from all participants before data collection [35].…”

Section: Ethical Considerationsmentioning

confidence: 99%

“…Individuals who met the following criteria were included: people diagnosed with idiopathic PD, 1 to 3 on the Hoehn &Yahr (H&Y) scale and physically inactive for at least one month. They should be on regular drug treatment and have the ability to understand verbal instructions to perform tests and intervention [35].…”

Section: Study Populationmentioning

confidence: 99%

“…Exclusion criteria were determined as having a cognitive impairment (MEEM 24), deep brain stimulation surgery (DBS), history of vertigo, surgeries in lower limbs during the last year, use of prostheses in the lower limbs, severe heart diseases or other associated neurological diseases [35].…”

Section: Study Populationmentioning

confidence: 99%

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Aquatic exercise associated or not with grape juice consumption-modulated oxidative parameters in Parkinson disease patients: A randomized intervention study

Oliveira

Pinheiro

Proença

et al. 2021

Heliyon

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Parkinson's disease (PD) is a neurodegenerative disorder with significant motor disabilities and cognitive decline. Importantly, the imbalance of oxidative stress is related to PD physiopathology and progression. This study aimed to evaluate the impact of grape juice consumption associated with an aquatic exercise protocol on oxidative stress parameters and cognitive function in individuals with PD. The participants were randomized into two groups: grape juice group (GJG) and control group (CG) and were submitted to 4 weeks of an aquatic intervention (twice a week, approximately 60 minutes/session). The GJG also consumed 400 ml of grape juice per day (integral and conventional) during this period. Cognitive function was assessed by the Montreal Cognitive Assessment (MoCa) questionnaire. For the analysis of oxidative stress markers, specifically lipid oxidative damage (TBARS), proteins (Carbonil), acid uric and the activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase and catalase), blood collection were done before and after intervention. No changes were observed in cognitive function after intervention in both groups. Regarding biomarkers, a reduction of antioxidant enzymes, thiobarbituric acid reactive substances (TBARS) and uric acid was observed in both groups. However, only the GJG showed a significant reduction on protein oxidation levels after intervention. In conclusion, the consumption of grape juice associated with an aquatic exercise protocol might be consider an effective alternative to reduce the oxidative damage in PD, reinforcing the importance of this intervention in promoting beneficial impact in this population.

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Section: Methodsmentioning

confidence: 99%

Section: Ethical Considerationsmentioning

confidence: 99%

“…All methods were performed following the relevant guidelines and regulations. Written informed consent was obtained from all participants before data collection [35].…”

Section: Ethical Considerationsmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

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