Effect of exercise intensity on 6-keto-PGF1α, TXB2, and 6-keto-PGF1α/TXB2 ratios

Todd, M. Kent; Goldfarb, Allan H.; Boyer, Brooke

doi:10.1016/0049-3848(92)90200-t

Cited by 22 publications

(14 citation statements)

References 9 publications

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“…Laustiola et al and Carter et al observed that plasma levels of 6-keto PGF 1 α increased following a low-intensity (30–50% VO 2 max) bout of exercise, which suggests that exercise at lower intensities may stimulate a greater production of 6-keto PGF 1 α [16]. This trend was seen in the present study population with a 1.5-fold to 2-fold increase in 6-keto PGF 1 α .…”

Section: Discussionsupporting

confidence: 70%

“…It has been suggested that metabolic activity in the arachidonic acid cascade may be increased equally at various exercise intensity levels, but that the synthesis of PGI 2 and TXA 2 may be more heavily influenced by the exercise intensity level [16]. Alternatively, the conversion of arachidonic acid to eicosanoids other than PGI 2 and TXA 2 may be affected by exercise, which may be responsible for the observed decrease in 11-dTXB 2 following the acute exercise bout.…”

Section: Discussionmentioning

confidence: 99%

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Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives

Williamson

Varma

Brown

et al. 2011

Journal of Aging Research

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Endothelial dysfunction and a sedentary lifestyle may be involved in the development of hypertension which is proliferative among middle-aged African Americans (AA). Signaling molecules derived from the oxidation of 20-carbon fatty acid molecules known as eicosanoids influence vascular tone. The relationship between aerobic fitness and eicosanoid formation following exercise in middle-aged African American hypertensives is unknown. Purpose. To determine the relationship between aerobic capacity and eicosanoid formation after a bout of moderate-intensity exercise in middle-aged AA hypertensives. Methods. Ten sedentary hypertensive AA underwent 50 min of aerobic exercise at 65% VO2max. Urine was collected for 24 hr on two occasions, prior to testing and immediately following the bout of exercise. Urinary metabolites of prostacyclin (6-keto PGF1α) and thromboxane (11-dTXB2) were measured during the day and night periods by high-performance liquid chromatography (HPLC). Results. 6-keto PGF1α levels significantly increased (P = .04) following the bout of exercise compared to the control day. There was a significant relationship (r = .49, P < .05) between 6-keto PGF1α levels and VO2max during the exercise day. Conclusion. Based on this preliminary study, there appears to be a relationship between aerobic capacity and exercise-induced 6-keto PGF1α production in middle-aged hypertensive AAs. AAs with lower VO2max had lower 6-keto PGF1α formation.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives

Williamson

Varma

Brown

et al. 2011

Journal of Aging Research

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“…Exercise also results in platelet activation and consequent TXB 2 production. It also activates leukocytes and promotes platelet-leukocyte aggregate formation (24,25). Hence, local eicosanoid production is associated with strenuous physical activities in healthy individuals and these autocoids may serve in homeostatic mechanism(s) to limit exercise-induced responses.…”

Section: Discussionmentioning

confidence: 99%

Aspirin triggers antiinflammatory 15-epi-lipoxin A ₄ and inhibits thromboxane in a randomized human trial

Chiang

Bermudez

Ridker

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

247

210

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There is increasing evidence that aspirin initiates biosynthesis of novel antiinflammatory mediators by means of interactions between endothelial cells and leukocytes. These mediators are classified as aspirin-triggered 15-epi-lipoxins. Such compounds may account at least in part for aspirin's clinical benefits, which are distinct from the well appreciated action of aspirin as a platelet inhibitor. Here, we addressed whether aspirin-triggered 15-epilipoxinA4 (ATL) formation is aspirin-dependent in humans and its relationship to aspirin's antiplatelet activity. We conducted a randomized clinical trial among 128 healthy subjects allocated to placebo or to 81-, 325-, or 650-mg daily doses of aspirin for 8 weeks.

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“…Previous reports indicated that mild to moderate exercise might stimulate a greater increase in 6-keto-PGF1l, concentration than severe exercise did and that severe exercise increased thromboxane levels.31-33 It was also noticed that the ratio of 6-keto-PGFl,a to thromboxane B2 was elevated after moderate exercise, whereas this ratio was decreased by severe exercise. 33 Moncada and Vane34 suggested that the ratio between prostacyclin and thromboxane A2 has an important role in determining the extent of platelet aggregation, and the lower the ratio, the greater one's predisposition toward platelet aggregation. Hirsh et a1l also suggested that local thromboxane release might be associated with recent episodes of angina in patients with unstable coronary heart disease.…”

Section: Discussionmentioning

confidence: 99%

Different effects of strenuous exercise and moderate exercise on platelet function in men.

et al. 1994

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BACKGROUND Platelets play an important role in the pathogenesis of cardiovascular diseases. It is also noticed that on one hand, regular exercise can reduce the risk of cardiovascular diseases, and on the other hand, vigorous exercise provokes sudden cardiac death. We therefore hypothesize that various intensities of exercise may affect platelet function differently. METHODS AND RESULTS Strenuous and moderate exercise (about 50% to 55% of peak oxygen consumption, VO2peak) on a bicycle ergometer in 10 sedentary and 10 physically active healthy young men was executed on two separate occasions. Blood samples were collected before and immediately after exercise. A newly designed tapered parallel plate chamber was used to assess platelet adhesiveness. Platelet aggregation induced by ADP was evaluated by the percentage of reduction in single platelet count. beta-Thromboglobulin (beta-TG) and platelet factor 4 (PF4) were measured by ELISA. In addition, a similar study on 5 patients with stable angina were also conducted. Our results showed that (1) in the sedentary healthy group, platelet adhesiveness and aggregation were increased by strenuous exercise and depressed by moderate exercise; (2) in the active healthy group, platelet adhesiveness and aggregation were enhanced by severe exercise, whereas only aggregation was decreased by moderate exercise; (3) in the patients with stable angina, platelet adhesiveness and aggregation were enhanced by strenuous exercise and adhesiveness was suppressed by moderate exercise; (4) the degree of hemoconcentration induced by acute exercise tended to be related to the severity of exercise in all subjects; and (5) although severe exercise elevated beta-TG and PF4, there were no significant changes in beta-TG, PF4, and the ratio of beta-TG to PF4 in healthy subjects after exercise. CONCLUSIONS It is concluded that platelet adhesiveness and aggregability may be sensitized by strenuous exercise in both healthy subjects and patients with stable angina. In contrast, platelet function can be suppressed significantly by moderate exercise in the healthy and tends to be depressed in patients with stable angina. The former may increase the risk of cardiac arrest and the latter may protect us from cardiovascular diseases. In addition, the effects of acute exercise tend to be more pronounced in the sedentary than in the active.

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Effect of exercise intensity on 6-keto-PGF1α, TXB2, and 6-keto-PGF1α/TXB2 ratios

Cited by 22 publications

References 9 publications

Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives

Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives

Aspirin triggers antiinflammatory 15-epi-lipoxin A ₄ and inhibits thromboxane in a randomized human trial

Different effects of strenuous exercise and moderate exercise on platelet function in men.

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Effect of exercise intensity on 6-keto-PGF1α, TXB2, and 6-keto-PGF1α/TXB2 ratios

Cited by 22 publications

References 9 publications

Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives

Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives

Aspirin triggers antiinflammatory 15-epi-lipoxin A 4 and inhibits thromboxane in a randomized human trial

Different effects of strenuous exercise and moderate exercise on platelet function in men.

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Product

Resources

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Aspirin triggers antiinflammatory 15-epi-lipoxin A ₄ and inhibits thromboxane in a randomized human trial