Effect of exercise on concentrations of irisin in overweight individuals: A systematic review

Andrade, Patrícia Amaro; Silveira, Brenda Kelly Souza; Rodrigues, Aurora Corrêa; Silva, F.M. Oliveira da; Rosa, C.O. Barbosa; Alfenas, R. C.

doi:10.1016/j.scispo.2017.11.002

Cited by 14 publications

(12 citation statements)

References 25 publications

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“…Another interspecies difference irisin shows is that its browning effects in humans may be different than those in rodents. Indeed, irisin decreases browning-related genes in human preadipocytes but increases said genes in mature human adipocytes [6, 21].…”

Section: Resultsmentioning

confidence: 99%

“…Indeed, one of these myokines, irisin, which was only recently discovered, has been shown to have numerous benefits not only in fighting metabolic diseases but also in combating cancer [4]. Recent reviews in the literature link irisin and exercise, concluding that irisin increases after exercise, however only transiently [6]; irisin, obesity, and metabolic diseases have also been linked [7], but no review summarizes the studies that show the effect of irisin on cancer or cancer biology. An investigation into the available literature shows that irisin has direct effects on different types of cancers.…”

Section: Introductionmentioning

confidence: 99%

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Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent

Maalouf

Khoury

2019

Journal of Obesity

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Irisin is a recently discovered myokine that plays an important role in fat metabolism through the browning of white adipose tissue. This myokine is usually secreted after exercise by improving energy balance and has shown great potential as a possible treatment for some metabolic diseases such as obesity, insulin resistance, and inflammation. Obesity has been linked to a higher incidence of some cancers. Furthermore, some studies have shown irisin to have direct positive effects on different types of cancers. Although it is hard to relay conclusions from in vitro to in vivo studies, the majority of the available data favor irisin as a potential substance for cancer regression through reducing proinflammatory markers linked to obesity. However, some controversies remain on the exact benefits of irisin on cancer with some studies showing no or even a negative effect of irisin on cancer. This review summarizes these 2 differing viewpoints and synthesizes them to form a clearer picture of exercise-induced irisin’s effects on cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent

Maalouf

Khoury

2019

Journal of Obesity

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“…It is known that physical exercise is a factor increasing irisin secretion in obese people [42]. In two earlier conducted studies, it was indicated that exposure to cryogenic temperatures may also be a factor inducing the secretion of this hormone, although the studies were carried out only in men, both with normal body mass [43] and those obese [26].…”

Section: Introductionmentioning

confidence: 99%

Whole-Body Cryotherapy Is an Effective Method of Reducing Abdominal Obesity in Menopausal Women with Metabolic Syndrome

Więcek

Szymura

Sproull

et al. 2020

JCM

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Abdominal obesity predominates in menopausal women (MW) and contributes to the development of metabolic syndrome (MetS). It is associated with increased mortality related to cardiovascular disease, diabetes and fatty liver disease. The effects of whole-body cryotherapy (WBC) on body composition and the blood concentration of irisin, interleukin-6 (IL-6) and C-reactive proteins (CRP) in MW with MetS and in healthy women (HW), were assessed. The study included 19 women with MetS (61.53 ± 3.99 y, BMI 30.09 ± 4.98 kg/m2) and 18 HW (60.28 ± 3.63 y, BMI 25.50 ± 2.37 kg/m2) who were subjected to 20 WBC treatments at −130 °C for 3 min daily. In both groups, body mass (BM), BMI, abdominal circumference, triceps skinfold, total fat mass and percentage of leg fat significantly decreased after 20 WBC sessions. Additionally, the percentage of total, trunk and android fat in the MetS group were significantly decreased after 20 WBC applications. Waist circumference (WC) and waist-to-height ratio (WHtR) significantly decreased in both groups, and in the HW group, hip circumference and abdominal skinfold also significantly decreased after 10 WBC and 20 WBC treatments. In both groups, the concentration of plasma irisin significantly increased after 1 WBC and 10 WBC exposures, while the concentration of IL-6 significantly increased only in MetS group after 10 WBC and 20 WBC, and were significantly higher than in HW. CRP concentrations were significantly higher in the MetS group than in HW before 1 WBC, after 1 WBC and 10 WBC sessions, but not after 20. In the MetS group, there were significant negative correlations between the change in irisin level and the changes in WC and BM, and between the level of irisin and the change in percentage of total fat, and significant negative correlations between the change in IL-6 level and changes in WC, waist-to-hip ratio and WHtR. Whole-body cryotherapy, assuming the application of 20 treatments in the series, reduces abdominal obesity in menopausal women indirectly through the secretion of irisin and IL-6, and can be used as adjunctive therapy in the treatment of metabolic syndrome. Our conclusion is limited to menopausal women with low–moderate physical activity for whom its level as well as diet were not changed during the treatment.

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“…Given the potential of exercise as a preventative and/or adjuvant therapeutic approach for AD, a thorough understanding of exercise‐linked molecular and signaling mechanisms is warranted. Recent evidence suggests that chronic high‐intensity exercise induces significant increases in key plasma hormones, proteins, or miRNAs related to the beneficial effects of exercise in mice and humans (Amaro Andrade et al., 2018; Dinas et al, 2017; Fox et al., 2018). Such effects may be linked to the reduced risk of cognitive decline reminiscent of mild cognitive impairment (MCI) or AD (Buchman et al., 2012).…”

Section: The Brain‐derived Neurotrophic Factor In the Exercise‐linkedmentioning

confidence: 99%

Protective actions of exercise‐related FNDC5/Irisin in memory and Alzheimer’s disease

Freitas

Lourenco

Felice

2020

Journal of Neurochemistry

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The proportion of elderly populations is rapidly booming, and human lifespan has considerably increased in the past century because of scientific and medical advances. However, the winds of change brought by the 21st century made sedentarism one of the factors that renders the brain vulnerable to age-related chronic diseases, such as Alzheimer's disease (AD). Conversely, physical exercise has been shown to stimulate molecular mechanisms beneficial to cognition. Here, we review evidence showing the positive effects of physical exercise in the brain. We further discuss recent evidence that irisin, a myokine stimulated by physical exercise derived from fibronectin type III domain-containing protein 5 (FNDC5) transmembrane protein, has neuroprotective actions in the brain. Lastly, we highlight the importance of the crosstalk between the periphery and the brain in cognition and the therapeutic potential of FNDC5/irisin in AD.

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Effect of exercise on concentrations of irisin in overweight individuals: A systematic review

Cited by 14 publications

References 25 publications

Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent

Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent

Whole-Body Cryotherapy Is an Effective Method of Reducing Abdominal Obesity in Menopausal Women with Metabolic Syndrome

Protective actions of exercise‐related FNDC5/Irisin in memory and Alzheimer’s disease

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