Effect of exercise on serum concentration of cartilage oligomeric matrix protein in Thoroughbreds

Helal, Ibrahim E.; Misumi, Kazuhiro; Tateno, Oki; Kodama, Takeshi; Ishimaru, Mutsuki; Yamamoto, Junya; Miyakoshi, Daiske; Fujiki, Makoto

doi:10.2460/ajvr.68.2.134

Cited by 12 publications

(8 citation statements)

References 29 publications

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“…Similar results have also been reported for other cartilage constituents including aggrecan, hyaluronan, and keratan sulfate in healthy athletes, 23 and for COMP in thoroughbreds free of orthopedic disease. 24 Table However, the delayed increase in serum COMP concentration, as reported in our previous study 18 of a younger population, was not observed in the OA patients nor in the age-matched healthy control subjects in the present study. This discrepancy suggests the possibility that the influence of exercise on cartilage turnover is dependent on age.…”

Section: Discussioncontrasting

confidence: 37%

Change in serum COMP concentration due to ambulatory load is not related to knee OA Status

Mündermann

King

Smith

et al. 2009

Journal Orthopaedic Research

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The aim of this study was to test the hypothesis that a change in serum cartilage oligomeric matrix protein (COMP) concentration is related to joint load during a 30-min walking exercise in patients with medial compartment knee osteoarthritis (OA) and in age-matched control subjects. Blood samples were drawn from 42 patients with medial compartment knee OA and from 41 healthy age-matched control subjects immediately before, immediately after, and 0.5, 1.5, 3.5, and 5.5 h after a 30-min walking exercise on a level outdoor walking track at self-selected normal speed. Serum COMP concentrations were determined using a commercial ELISA. Basic time-distance gait variables were recorded using an activity monitor. Joint loads were measured using gait analysis. Serum COMP concentrations increased immediately after the walking exercise (+6.3% and +5.6%; p < 0.001) and decreased over 5.5 h after the exercise (-11.1% and -14.6%; p < 0.040 and p = 0.001) in patients and control subjects, respectively. The magnitude of increase in COMP concentration did not differ between groups (p = 0.902) and did not correlate with any variables describing ambulatory loads at the joints of the lower extremity. These results, taken together with a previous study of a younger healthy population, suggest the possibility that the influence of ambulatory loads on cartilage turnover is dependent on age.

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Section: Discussioncontrasting

confidence: 37%

Change in serum COMP concentration due to ambulatory load is not related to knee OA Status

Mündermann

King

Smith

et al. 2009

Journal Orthopaedic Research

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“…We previously speculated that the increase in the serum COMP level relative to the SF level might be modest due to effective dilution by blood volume, and might also be further obscured by a non-specific factor present during daily activity [13]. In the present study, we found an extrapolation to a polynomial expression between the serum level of COMP and the period from injury to surgery, despite the lack of a significant difference in the serum level between OP(-) and OP(+) horses.…”

Section: Discussionmentioning

confidence: 99%

“…There may be specific reasons why serum COMP may be a less sensitive indicator of joint deterioration in equine OA. Exercise-induced up-regulation of COMP turnover might be one factor that would complicate the detection of changes in serum COMP concentration due to OA pathology in horses [13]. Also, differences in OA pathology, described as a multifactorial disease secondary to fracture, osteochondrosis, degenerative joint disease, and septic arthritis in different joints, should be taken into consideration in biomarker analysis.…”

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confidence: 99%

Analysis of Cartilage Oligomeric Matrix Protein (COMP) in Synovial Fluid, Serum and Urine from 51 Racehorses with Carpal Bone Fracture

Arai

Tagami

Hatazoe

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. We investigated the relationship between cartilage oligomeric matrix protein (COMP) levels in synovial fluid (SF), serum and urine and the development of osteochondral damage and osteophyte (OP) formation following intraarticular fractures of the carpus in racehorses in order to assess the clinical usefulness of COMP as a diagnostic biomarker of developmental osteoarthritis (OA). Two monoclonal antibodies (mAb clones 2A11 and 3C8) raised against equine COMP were shown to be capable of detecting the molecule in serum and urine as well as SF. Fifty-one samples were obtained from 26 OP-positive (OP(+)) and 25 OP-negative (OP(-)) racehorses with carpal bone fracture, in whom OP was ascertained arthroscopically and radiographically. The COMP measurements obtained using the two mAbs were highly correlated with each other in SF, serum, or urine. Horses with OP(+) showed a significantly higher [urinary COMP (µg)]/[urinary creatinine (mg)] ratio (4.94 ± 5.10 and 1.46 ± 1.19, using mAbs 2A11 and 3C8, respectively) than OP(-) horses (2.80 ± 1.72 and 0.93 ± 0.49, respectively). The relationship between serum and urine COMP levels and the period from injury to surgery were extrapolated using a polynomial expression. Measurement of COMP, especially in urine, has potential as a predictive marker of advanced OA following carpal bone fractures in racehorses. KEY WORDS: COMP, equine, fracture, osteoarthritis, urine.J. Vet. Med. Sci. 70(9): 915-921, 2008 Cartilage oligomeric matrix protein (COMP), an abundant non-collagenous extracellular matrix protein in cartilage [1], plays an important role in the construction of collagen bundles and networks, being likely involved in determination of fibril diameter and/or orientation [2,3] and interaction with other extracellular matrix molecules [4]. A recent study has also suggested that association of COMP with granulin-epithelin precursor could be required for chondrocyte proliferation [5]. COMP may also play a role in the pathogenesis of osteoarthritis (OA) as a factor secreted by chondrocytes to ameliorate matrix breakdown at the late stage of OA [6]. In human OA, measurement of COMP in serum and synovial fluid (SF) has been proposed as a helpful biomarker for predicting disease-mediated damage to joint cartilage [7,8]. The serum COMP level is reportedly higher in patients with OA than in healthy volunteers [9]. The serum level of COMP is significantly correlated with the Western Ontario and McMaster Universities index pain scale for the lower limbs, and is higher in patients with bilateral knee OA than in unilaterally affected patients [10]. Another study has suggested that serum COMP level at the baseline could be useful for predicting the course of OA, progressors showing higher average values than nonprogressors [11].In studies of horses, we have demonstrated enhanced degradation of COMP in SF, and suggested that COMP fragmentation in SF could be useful for monitoring equine OA in combination with ELISA measurements [12]. Subsequently, we investigated the clinical use...

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“…For instance, it was found that levels of COMP in serum and synovial fluid were higher in dogs that underwent high-intensity training compared to the common or no training group (Qi and Changlin, 2006). Serum COMP concentrations of horses were also significantly elevated in response to exercise, and it was concluded that exercise may enhance both the release of COMP into the circulation and its general turnover rate (Helal et al, 2007). Previously it had been reported that physiological cyclic loading during walking exercise caused an increase in serum COMP concentration in a healthy population showing both an immediate and a delayed response (Mü ndermann et al, 2005).…”

Section: Article In Pressmentioning

confidence: 95%

The effect of sliding velocity on chondrocytes activity in 3D scaffolds

Wimmer

Alini

Grad

2009

Journal of Biomechanics

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Effect of exercise on serum concentration of cartilage oligomeric matrix protein in Thoroughbreds

Abstract: Serum COMP concentrations changed significantly in response to exercise. Exercise may enhance movement of COMP into the circulation as well as change the basal turnover rate of COMP.

Cited by 12 publications

References 29 publications

Change in serum COMP concentration due to ambulatory load is not related to knee OA Status

Change in serum COMP concentration due to ambulatory load is not related to knee OA Status

Analysis of Cartilage Oligomeric Matrix Protein (COMP) in Synovial Fluid, Serum and Urine from 51 Racehorses with Carpal Bone Fracture

The effect of sliding velocity on chondrocytes activity in 3D scaffolds

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