Effect of exocrine pancreatic function on resting energy expenditure in cystic fibrosis

Moudiou, Tatiana; Galli-Tsinopoulou, Assimina; Nousia-Arvanitakis, Sanda

doi:10.1111/j.1651-2227.2007.00478.x

Cited by 18 publications

(18 citation statements)

References 22 publications

(27 reference statements)

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“…The American CF Adult Care Consensus defines FEV 1 ≥70% of predicted value as normal or mild lung dysfunction (10). Additional findings support the notion that genotype and PI may be determinants of REE (7, 11, 12). …”

supporting

confidence: 77%

Dietary intake and nutritional status in a Scandinavian adult cystic fibrosis-population compared with recommendations

Moen¹,

Nilsson²,

Andersson³

et al. 2011

Food & Nutrition Research

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BackgroundMalnutrition is a well-known complication in cystic fibrosis (CF). There is good evidence that maintaining a normal body-weight correlates well with improved survival in CF. Energy intake in excess of 120% of the estimated average requirement (EAR) has been advised since 1980s.ObjectivesTo investigate the nutritional intake and status in the adult Scandinavian CF-population.Subjects/MethodsA cross-sectional multi-centre study was used to investigate the nutritional status of 456 adult CF-patients (2003 2006). Height and weight were measured and body mass index (BMI) and z-scores were calculated. Pulmonary function was examined by dynamic spirometry. A 7-day pre-coded food record (FR) obtained energy and nutrient intake data in 180 patients.ResultsThe mean energy intake was 114 (SD 30.0)% of EAR and thus significantly lower than the target of 120% EAR (p< 0.001) for patients with pancreatic insufficiency (PI) (n=136). Mean BMI was 22.0 (SD 2.9), the prevalence of BMI <18 was 13% and the prevalence of BMI ≥25 was 15% (n=136). Mean BMI was 20.8 (SD 2.4) in PI-patients with FEV1 <70% and 23.2% (SD 3.0), in PI-patients with FEV1 ≥70%, mean difference 2.4, (95% CI: 1.5, 3.3) (p<0.001), but there was no difference in energy intake. BMI ≥18.5 and a reported energy intake <120% were revealed in 54% of the PI-patients.ConclusionsThe energy intake did not reach the recommended 120% EAR, but the prevalence of underweight was lower than reported in other studies. The recommendation may exceed the requirement for a number of CF-patients. The nutritional status must still be closely monitored and nutritional advice and intervention should be individualised and adjusted to actual needs.

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supporting

confidence: 77%

Dietary intake and nutritional status in a Scandinavian adult cystic fibrosis-population compared with recommendations

Moen¹,

Nilsson²,

Andersson³

et al. 2011

Food & Nutrition Research

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“…These studied showed that at rest REE was greater than similar healthy non‐CF patients 51 – 56 . An additional study also showed REE was also greater than predicted REE compared to the Schofield H‐W equation 57 . Studies also demonstrated that there is a strong correlation between pancreatic sufficiency status and REE.…”

Section: Increased Energy Requirementsmentioning

confidence: 93%

“…Studies also demonstrated that there is a strong correlation between pancreatic sufficiency status and REE. Those patients who were diagnosed as being pancreatic sufficient exhibited normal REE compared to healthy subjects 57 . A longitudinal study in well children in Australia concluded that males typically have a lower REE than females.…”

Section: Increased Energy Requirementsmentioning

confidence: 99%

“…In regard to the CF Foundation guidelines that patients should be at a BMI or weight/length > 50th percentile, these guidelines were developed using the entire CF patient population, but did provide separate guidelines based on genotype‐specifically whether patients were pancreatic sufficient or pancreatic insufficient. Research shows that patients whose genotypes are classified as pancreatic sufficient tend to have better outcomes and a near normal REE 57 . This raises a question whether different nutrition recommendations should be made for these patients.…”

Section: Challenges/limitationsmentioning

confidence: 99%

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Malnutrition in Cystic Fibrosis

et al. 2013

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Malnutrition is one of the main burdens of disease in cystic fibrosis (CF) along with lung disease. Data from the most recent Cystic Fibrosis Foundation registry report show the prevalence of malnutrition is decreasing in the CF population primarily from interventions focusing on preventing malnutrition. Despite success of interventions and decreased prevalence of malnutrition in this population, prevention of malnutrition in CF patients remains a dilemma that must be managed throughout the life cycle. The pathogenesis of malnutrition in CF can be further categorized into 3 main areas: increased energy losses, increased energy needs, and inadequate calorie intake. The purpose of this review is to further explore the causes of malnutrition and explain current research to prevent malnutrition in the CF population.

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“…Disease‐specific risk factors for malnutrition in children with CF include increased REE, chronic inflammation, malabsorption secondary to pancreatic insufficiency, fat‐soluble vitamin deficiencies, CF‐related diabetes, and decreased appetite often related to multiple factors including constipation, reflux, chronic inflammation, and small intestinal bacterial overgrowth . Behavioral feeding problems are also common in patients with CF …”

Section: Cystic Fibrosismentioning

confidence: 99%

Malnutrition in Children With Chronic Disease

Larson‐Nath

Goday

2019

Nut in Clin Prac

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Malnutrition occurs when nutrient intake does not meet the needs for normal body functions and as a consequence leads to alterations of growth and development in children. Chronic illness puts children at risk for developing malnutrition. Because of children's rapid periods of growth and development, early diagnosis, prevention, and management of malnutrition are paramount. The reasons for malnutrition in children with chronic disease are multifactorial and are related to the underlying disease and nonillness-associated factors. This review addresses the causes, evaluation, and management of malnutrition in pediatric congenital heart disease, chronic kidney disease, liver disease, and cystic fibrosis. (Nutr Clin Pract. 2019;34:349-358)

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Effect of exocrine pancreatic function on resting energy expenditure in cystic fibrosis

Cited by 18 publications

References 22 publications

Dietary intake and nutritional status in a Scandinavian adult cystic fibrosis-population compared with recommendations

Dietary intake and nutritional status in a Scandinavian adult cystic fibrosis-population compared with recommendations

Malnutrition in Cystic Fibrosis

Malnutrition in Children With Chronic Disease

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